ABSTRACT
OBJECTIVES: Conventional methods of imaging neuroendocrine tumors with computed tomography, magnetic resonance imaging, indium-111-octreotide, or radiolabeled metaiodobenzilguanidine scintigraphy have limitations. This pilot study tried to improve the localization of these tumors with fluorine-18-fluorodihydroxyphenylalanine (F-DOPA) positron-emission tomography (PET) scanning. MATERIALS AND METHODS: We studied 22 patients, the majority of whom were referred with clinical diagnosis or suspicion of carcinoid (n = 11), neuroendocrine tumors (n = 7) or pheochromocytoma/paraganglioma (PGL) (n = 4). The comparison was made with the prior conventional imaging. RESULTS: The F-DOPA findings were compared with the results of subsequent surgery (2), endoscopy (1), or a long-term follow-up (mean duration, 49 months) for 17 patients. Two patients were lost to follow-up. Foci of F-DOPA deposition were detected in eight patients (final diagnosis of carcinoid in six, of neuroendocrine tumors in one, and of PGL in another). Comparison with the final diagnoses revealed concordance in 16 of the 22 patients. F-DOPA results appeared superior to those obtained with conventional imaging. Despite the small number and diagnostic heterogeneity, in a substantial fraction of patients F-DOPA PET added information relevant to clinical management. CONCLUSION: F-DOPA scanning added prognostic value, particularly when multiple abnormal foci versus a negative examination were considered.
Subject(s)
Carcinoid Tumor/diagnostic imaging , Lithium Compounds/therapeutic use , Positron-Emission Tomography/methods , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/secondary , Carcinoid Tumor/pathology , Dihydroxyphenylalanine , Fluorodeoxyglucose F18 , Humans , Lithium Compounds/adverse effects , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/secondary , Male , Mood Disorders/drug therapy , Positron-Emission Tomography/standards , Reproducibility of Results , Sensitivity and Specificity , Young AdultSubject(s)
Cholecystitis, Acute/diagnostic imaging , Cholecystolithiasis/diagnostic imaging , Cholecystitis, Acute/complications , Cholecystitis, Acute/diagnosis , Cholecystitis, Acute/surgery , Cholecystolithiasis/complications , Cholecystolithiasis/diagnosis , Cholecystolithiasis/surgery , Gallbladder Diseases/complications , Gallbladder Diseases/diagnosis , Gallbladder Diseases/diagnostic imaging , Gallbladder Diseases/surgery , Humans , Male , Middle Aged , Radionuclide Imaging , Rupture, Spontaneous/diagnosis , Rupture, Spontaneous/diagnostic imaging , Rupture, Spontaneous/etiology , Rupture, Spontaneous/surgeryABSTRACT
A 77-year-old man with Gleason score 7 prostate cancer, after radical prostatectomy, in whom the prostate-specific antigen level increased to 5.0 ng/mL 8 years later, underwent a ProstaScint scan. Radiotracer deposition was noted in the prostatic "fossa," highly suspicious of recurrence. An additional focus in the mid abdomen was suspicious of adenopathy. Computed tomography disclosed an abdominal mass that, at biopsy, proved to be a malignant B-cell lymphoma. That lesion resolved after chemotherapy, and the prostate-specific antigen level substantially decreased with hormonal treatment. The possible association of prostate cancer and lymphoma is discussed.
Subject(s)
Antibodies, Monoclonal , Lymphoma, B-Cell/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Radioimmunodetection/methods , Aged , Humans , Lymphatic Metastasis/diagnostic imaging , MaleABSTRACT
When the records of 136 persons suffering from hyperthyroidism (13 men and 123 women between 20 and 61 years of age), were analyzed, some relations were suggested between the clinical and laboratory antecedents, on the one hand, and the size of the dose administered with the incidence of post-treatment hypothyroidism on the other. A more complete study, preferably on a regional level, is definitely recommended to reach significant conclusions which might orient treatment norms(AU)
Subject(s)
Hyperthyroidism/prevention & control , Hyperthyroidism/drug therapy , Hyperthyroidism/metabolism , Iodine/therapy , Prevalence , ChileABSTRACT
When the records of 136 persons suffering from hyperthyroidism (13 men and 123 women between 20 and 61 years of age), were analyzed, some relations were suggested between the clinical and laboratory antecedents, on the one hand, and the size of the dose administered with the incidence of post-treatment hypothyroidism on the other. A more complete study, preferably on a regional level, is definitely recommended to reach significant conclusions which might orient treatment norms(AU)
