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1.
Transfusion ; 57(10): 2483-2489, 2017 10.
Article in English | MEDLINE | ID: mdl-28714229

ABSTRACT

BACKGROUND: Blood transfusions are a common and costly intervention for cardiac surgery patients. Evidence suggests that a more restrictive transfusion strategy may reduce costs and transfusion-related complications without increasing perioperative morbidity and mortality. STUDY DESIGN AND METHODS: A transfusion-limiting protocol was developed and implemented in a cardiovascular surgery unit. Over a 5-year period, data were collected on patient characteristics, procedures, utilization of blood products, morbidity, and mortality, and these were compared before and after the protocol was implemented. RESULTS: After the protocol was put in place, fewer patients required transfusions (38.2% vs. 45.5%, p = 0.004), with the greatest reduction observed in postoperative blood use (29.1% vs. 37.2%, p = 0.001). In-hospital morbidity and mortality did not increase. When patients who received transfusions were stratified by procedure, the protocol was most effective in reducing transfusions for patients undergoing isolated coronary artery bypass grafting (CABG; 4.09 units vs. 2.51 units, p = 0.009) and CABG plus valve surgery (10.32 units vs. 4.77 units, p = 0.014). A small group of patients were disproportionate recipients of transfusions, with approximately 6% of all patients receiving approximately half of the blood products. CONCLUSION: A protocol to limit transfusions decreased the proportion of cardiothoracic surgery patients who received blood products. A very small group of patients received a large number of transfusions, and within that group the observed mortality was significantly higher than in the general patient population. Current protocols cannot possibly account for these patients, and this should be considered when analyzing the performance of protocols designed to reduce unnecessary transfusions.


Subject(s)
Blood Transfusion/statistics & numerical data , Cardiac Surgical Procedures/economics , Clinical Protocols , Blood Transfusion/economics , Comorbidity , Coronary Artery Bypass , Hospital Mortality , Humans , Postoperative Care/methods
2.
Eur J Cardiothorac Surg ; 51(2): 368-375, 2017 02 01.
Article in English | MEDLINE | ID: mdl-28186272

ABSTRACT

OBJECTIVES: Utilization of bilateral internal mammary arteries (BIMAs) has been shown to improve long-term outcomes in patients undergoing coronary artery bypass grafting. To achieve complete revascularization, BIMAs may be used as either sole conduits for revascularization through a Y-graft configuration (BIMA-Y) or deployed with additional grafts used in conjunction with BIMAs. The purpose of this study was to compare the long-term outcomes of two institutions that predominantly used either the BIMA-Y configuration or BIMA plus additional grafts to achieve optimal revascularization. METHODS: From 1 January 2000 to 31 December 2010, 436 patients were revascularized using a non-sequential BIMA grafting at one institution (Group A), with veins being used for additional targets. At the second institution (Group B), 771 patients were revascularized using a BIMA-Y graft for all distal targets. Kaplan­Meier analysis was used to compare unadjusted survival between the groups. Cox proportional hazards regression modelling was used to provide an adjusted comparison of survival between the groups. RESULTS: There was no statistically significant difference between the average number of anastomotic sites used in Group A and Group B (A = 4.0 ± 0.7 vs B = 4.0 ± 0.7; P = 0.24). Group A did not have a significantly greater in-hospital mortality (0.7% vs 1.0% P = 0.39), stroke (0.5% vs 0.8% P = 0.40), deep sternal wound infection (0.0% vs 0.6% P = 0.11) or reoperation for bleeding (1.6% vs 0.6% P = 0.10) than Group B. Cox proportional hazards analyses demonstrated that at 14 years, Group B had a significantly improved survival compared to Group A (Group B = 88% vs Group A = 81%) with an overall reduction in mortality (adjusted hazard ratio 0.780, 95% confidence interval 0.448­0.849; P = 0.043). CONCLUSION: Utilization of the BIMA-Y configuration was associated with improved survival when compared to BIMA grafting with additional vein grafts. Further studies are necessary to evaluate the efficacy of BIMA-Y grafting against other means of providing complete arterial revascularization.


Subject(s)
Internal Mammary-Coronary Artery Anastomosis/methods , Aged , Belgium/epidemiology , Female , Hospital Mortality , Humans , Internal Mammary-Coronary Artery Anastomosis/adverse effects , Internal Mammary-Coronary Artery Anastomosis/mortality , Kaplan-Meier Estimate , Male , Middle Aged , New Jersey/epidemiology , Proportional Hazards Models , Reoperation , Retrospective Studies , Risk Factors , Saphenous Vein/transplantation , Stroke/epidemiology , Stroke/etiology , Surgical Wound Infection/epidemiology , Surgical Wound Infection/etiology , Treatment Outcome
3.
Eur J Cardiothorac Surg ; 49(1): 350-1, 2016 Jan.
Article in English | MEDLINE | ID: mdl-25669643

ABSTRACT

Performing a reoperative root replacement in cases of prosthetic valve endocarditis (PVE) can often be challenging due to significant inflammation and scarring. During these cases, surgeons may decide to utilize an interpositional graft when mobilization of the coronary ostia becomes too hazardous. The authors describe their experience performing a reoperative root replacement on a patient with PVE. In this case, the authors utilize a segment of the homograft left subclavian artery as an interpositional graft to provide an infection-resistant bioprosthetic graft that maintains coronary anatomy.


Subject(s)
Aorta, Thoracic/surgery , Blood Vessel Prosthesis Implantation/methods , Coronary Vessels/surgery , Prosthesis-Related Infections/surgery , Aged , Aortic Valve/surgery , Bioprosthesis/adverse effects , Endocarditis, Bacterial/surgery , Heart Valve Prosthesis/adverse effects , Heart Valve Prosthesis Implantation , Humans , Male , Reoperation/methods , Staphylococcal Infections/surgery
4.
Eur J Cardiothorac Surg ; 49(1): 203-10, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26003960

ABSTRACT

OBJECTIVES: Recent studies have demonstrated the superiority of bilateral internal mammary arteries (BIMAs) as conduit material for coronary artery bypass grafting (CABG) surgery. However, there is limited research on the effects of other graft conduits used in patients who require additional bypasses. The goal of this study was to evaluate the impact of the radial artery (RA) when used in conjunction with the BIMAs. METHODS: From the beginning of 2000 to the end of 2013, 4370 patients underwent CABG for three or more vessels at our institution. There were 568 and 183 patients who received BIMA + saphenous vein graft (SVG) and BIMA + radial ± SVG, respectively. Propensity matching was used to create a balanced cohort from these patients, which resulted in two groups of 183 patients. Thirty-day outcomes and long-term survival were compared between the two groups. Long-term follow-up was generated using the Social Security Death Index. RESULTS: There were no significant differences in preoperative characteristics. For 30-day outcomes, the BIMA + radial ± SVG group had more postoperative atrial fibrillation (24.6 vs 12.0%; P = 0.001) and a longer median postoperative length of stay (6 vs 5 days; interquartile range = 2; P = 0.016) than BIMA + SVG patients. There was no significant difference in long-term survival between the two groups over the 14-year period. However, before year 10, the BIMA + SVG group had a trend towards higher survival, whereas on follow-up after 10 years, there was a trend that favoured the BIMA + radial ± SVG patients. Cox regression analysis using a time-dependent covariate demonstrated that when the groups were split at 10 years, there was a statistically significant improvement in survival of the BIMA + radial ± SVG group [adjusted hazard ratio 0.254 95% confidence interval (CI) 0.062-0.977; P = 0.048] over BIMA + SVG patients between 10 and 14 years. CONCLUSIONS: Overall, there were no statistically significant differences in survival between the BIMA + SVG and BIMA + radial ± SVG groups over the 14 years. However, further analysis demonstrated that while the BIMA + radial ± SVG group had a trend towards decreased survival before 10 years, use of the RA in conjunction with BIMAs was associated with significantly increased survival in the later years. A larger cohort of patients with longer follow-up is needed to assess the outcomes of CABG using BIMA + radial ± SVG.


Subject(s)
Coronary Artery Bypass/methods , Coronary Artery Disease/surgery , Mammary Arteries/transplantation , Radial Artery/transplantation , Adult , Aged , Coronary Artery Disease/mortality , Female , Follow-Up Studies , Humans , Male , Middle Aged , Propensity Score , Retrospective Studies , Survival Analysis , Treatment Outcome
5.
J Surg Res ; 197(2): 265-9, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25963164

ABSTRACT

BACKGROUND: Ascending aortic dissections (AADs) require prompt diagnosis and surgical treatment. We present the results of implementing a multidisciplinary aortic dissection protocol on the outcomes of AAD treatment at a nonteaching hospital. METHODS: From January 2002-December 2013, 54 patients with the diagnosis of AAD were treated at our institution. Thirty-seven (68.5%) were male with a mean age of 62.3 y. Cardiogenic shock was present in 25.9% of patients. An AAD protocol, focused on educating physicians on presenting signs and symptoms, adequate triaging, and the need for immediate surgical intervention, was implemented, alongside the standardization of surgical treatment. We divided the cohort into two eras, based on AAD program's implementation in 2006, to better assess the impact of this protocol. RESULTS: Patients from the early era had significantly longer time from Emergency Department to the operating room, more postoperative occurrence of prolonged ventilation, and a longer postoperative hospital stay at 8.7 ± 8 versus 3.1 ± 2.6 h (P = 0.002), 63% versus 18% (P = 0.002), and 63% versus 18% (P = 0.002), respectively. The overall mortality for the cohort was 9.3%, decreasing from 12.5% before 2006 to 7.9% after 2006. CONCLUSIONS: The implementation of a multidisciplinary aortic dissection protocol has resulted in faster diagnosis and transport of AAD cases from the emergency room to the operating room, improving outcomes. Our data support the concept that nonteaching institutions can deliver excellent care to patients with acute aortic emergencies.


Subject(s)
Algorithms , Aortic Aneurysm , Aortic Dissection , Decision Support Techniques , Vascular Surgical Procedures , Adult , Aged , Aged, 80 and over , Aortic Dissection/diagnosis , Aortic Dissection/mortality , Aortic Dissection/surgery , Aortic Aneurysm/diagnosis , Aortic Aneurysm/mortality , Aortic Aneurysm/surgery , Clinical Protocols , Emergencies , Female , Humans , Male , Middle Aged , Patient Care Team , Retrospective Studies , Time Factors , Treatment Outcome
6.
J Thorac Cardiovasc Surg ; 149(4): 1027-33.e2, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25648476

ABSTRACT

OBJECTIVE: Previous studies have demonstrated that bilateral internal mammary artery (BIMA) grafts lead to superior outcomes compared with single internal mammary artery grafts. This study examines whether cardiopulmonary bypass affects conduit-dependent outcomes of coronary artery bypass grafting (CABG) surgery. METHODS: From 1994 to 2013, a total of 6666 patients underwent isolated CABG surgery at our institution. Of these procedures, 3548 (53.2%) were performed off pump. A BIMA-saphenous vein graft (SVG) was used in 1544, and 5122 had left internal mammary artery-SVGs. These 2 conduit groups differed significantly in baseline characteristics. Propensity matching based on 22 preoperative variables and using a nearest-neighbor matching algorithm was used to make balanced cohorts, resulting in 2 groups of 1006. To account for the influence of pump status on conduit selection, a second propensity score was developed for pump use. These cases were matched to create 4 patient cohorts of 353 patients each (a total of 1412), balanced for both conduit use and pump status. Late mortality was determined using the Social Security Death Index. RESULTS: No difference was found in survival between patients receiving BIMA-SVGs on or off pump (78.9% vs 79.1%). BIMA-SVGs outperformed the left internal mammary artery-SVGs regardless of whether the procedure was performed off pump (73.9%) or on pump (69.9%). CONCLUSIONS: This study demonstrates that the use of cardiopulmonary bypass does not significantly affect the long-term outcomes in these patients as long as full revascularization is achieved. In addition, these results are consistent with prior research showing that the use of BIMAs produces better outcomes than use of a single internal mammary artery when performing CABG.


Subject(s)
Cardiopulmonary Bypass , Coronary Artery Bypass, Off-Pump , Coronary Artery Bypass/methods , Coronary Artery Disease/surgery , Mammary Arteries/surgery , Saphenous Vein/transplantation , Cardiopulmonary Bypass/adverse effects , Cardiopulmonary Bypass/mortality , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/mortality , Coronary Artery Bypass, Off-Pump/adverse effects , Coronary Artery Bypass, Off-Pump/mortality , Coronary Artery Disease/diagnosis , Coronary Artery Disease/mortality , Databases, Factual , Female , Follow-Up Studies , Humans , Kaplan-Meier Estimate , Male , New Jersey , Propensity Score , Proportional Hazards Models , Retrospective Studies , Risk Factors , Time Factors , Treatment Outcome
7.
Asian Cardiovasc Thorac Ann ; 22(5): 566-73, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24867031

ABSTRACT

BACKGROUND: Elderly patients with aortic stenosis are under-referred for aortic valve replacement surgery. This study investigated the perioperative factors associated with midterm outcomes in a consecutive series of patients undergoing aortic valve replacement with or without coronary artery bypass graft surgery. METHODS: From 2006 to 2010, 509 patients having aortic valve replacement or aortic valve replacement with coronary artery bypass were grouped according to age (<80 years and ≥80 years) and procedure (aortic valve replacement ± coronary artery bypass). Patient survival was followed up for 5 years (mean 2.6 years). Midterm survival was evaluated using Kaplan-Meier and Cox proportional hazards regression model statistics. RESULTS AND CONCLUSIONS: 5-year survival among octogenarians was 59.2% with an observed 30-day mortality of 1% for aortic valve replacement and 3% for aortic valve replacement with coronary artery bypass. Kaplan-Meier survival analysis showed that age ≥80 years, New York Heart Association functional class III/IV, and left ventricular ejection fraction <35% were significantly associated with increased midterm mortality. Cox regression modeling demonstrated that age ≥80 years was the only significant independent factor associated with midterm mortality; older patients had a 3-fold increase in mortality (adjusted hazard ratio = 3.231, 95% confidence interval: 1.764-5.920, p < 0.0001). While hospital and 30-day mortality were not statistically different between age groups, age ≥80 years was the most powerful predictor of midterm death. These results support early aortic valve replacement with or without coronary artery bypass in aortic stenosis management.


Subject(s)
Aortic Valve Stenosis/surgery , Aortic Valve/surgery , Heart Valve Prosthesis Implantation , Aged , Aged, 80 and over , Aortic Valve/physiopathology , Aortic Valve Stenosis/mortality , Aortic Valve Stenosis/physiopathology , Coronary Artery Bypass , Coronary Artery Disease/mortality , Coronary Artery Disease/physiopathology , Coronary Artery Disease/surgery , Female , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/mortality , Hospital Mortality , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Proportional Hazards Models , Retrospective Studies , Risk Factors , Stroke Volume , Time Factors , Treatment Outcome , Ventricular Function, Left
8.
Genomics ; 104(1): 36-44, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24858532

ABSTRACT

In coronary artery bypass grafting (CABG), the combined use of left and right internal mammary arteries (LIMA and RIMA) - collectively known as bilateral IMAs (BIMAs) provides a survival advantage over the use of LIMA alone. However, gene expression in RIMA has never been compared to that in LIMA. Here we report a genome-wide transcriptional analysis of BIMA to investigate the expression profiles of these conduits in patients undergoing CABG. As expected, in comparing the BIMAs to the aorta, we found differences in pathways and processes associated with atherosclerosis, inflammation, and cell signaling - pathways which provide biological support for the observation that BIMA grafts deliver long-term benefits to the patients and protect against continued atherosclerosis. These data support the widespread use of BIMAs as the preferred conduits in CABG.


Subject(s)
Mammary Arteries/metabolism , Transcriptome , Aged , Aorta/metabolism , Coronary Artery Bypass/methods , Female , Gene Expression Profiling , Genome, Human , Humans , Male , Middle Aged , Organ Specificity
9.
Cardiovasc Pathol ; 23(1): 54-6, 2014.
Article in English | MEDLINE | ID: mdl-24012116

ABSTRACT

Juvenile xanthogranuloma is the most frequent type of non-Langerhans cell histiocytosis. It most commonly presents in infancy and early childhood; manifesting as cutaneous lesions on the head, neck, and trunk that suddenly appear and usually undergo spontaneous regression. Extracutaneous involvement, although rare, may occur along with the cutaneous form or in isolation. It most frequently involves the eye, deep subcutaneous tissues, lung, and liver. Involvement of the heart is exceptionally rare, with only seven reports found in the English literature, all affecting infants. We present the first report of an intracardiac juvenile xanthogranuloma in an adult.


Subject(s)
Heart Diseases/etiology , Xanthogranuloma, Juvenile/complications , Aged , Biopsy , Cardiac Surgical Procedures , Echocardiography, Doppler, Color , Echocardiography, Three-Dimensional , Echocardiography, Transesophageal , Female , Heart Diseases/diagnosis , Heart Diseases/surgery , Humans , Predictive Value of Tests , Treatment Outcome , Xanthogranuloma, Juvenile/diagnosis , Xanthogranuloma, Juvenile/surgery
10.
Transfusion ; 54(4): 1106-13, 2014 Apr.
Article in English | MEDLINE | ID: mdl-23909477

ABSTRACT

BACKGROUND: Studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality during the first year after surgery, but risk appears to decrease after the first year. This study compared 5-year mortality in a propensity-matched cohort of cardiac surgery patients. STUDY DESIGN AND METHODS: Between July 1, 2004, and June 30, 2011, 3516 patients had cardiac surgery with 1920 (54.6%) requiring blood transfusion. Propensity matching based on 22 baseline characteristics yielded two balanced groups (blood transfusion group [BTG] and nontransfused control group [NCG]) of 857 patients (1714 in total). The type and number of blood products were compared in the BTG. RESULTS: Operative mortality was higher in BTG versus NCG (2.3% vs. 0.4%; p < 0.0001). Kaplan-Meier analysis of 5-year survival demonstrated no difference between groups in the first 2 years (BTG 96.3% and 93.0% vs. NCG 96.4% and 93.9%, respectively). There was a significant divergence during Years 3 to 5 (BTG 82.0% vs. NCG 89.3% at 5 years; p < 0.007). Five-year survival was significantly lower in patients who received at least 2 units of blood (79.6% vs. 88.0%; p < 0.0001). In multivariate Cox regression analyses, transfusion was independently associated with increased risk for 5-year mortality. Patients receiving cryoprecipitate products had a twofold mortality risk increase (adjusted hazard ratio, 2.106; p = 0.002). CONCLUSION: Blood transfusion, specifically cryoprecipitates, was independently associated with increased 5-year mortality. Transfusion during cardiac surgery should be limited to patients who are in critical need of blood products.


Subject(s)
Blood Transfusion/mortality , Cardiac Surgical Procedures/mortality , Aged , Aged, 80 and over , Case-Control Studies , Female , Humans , Intraoperative Care/methods , Male , Middle Aged , Mortality , Risk Factors , Survival Analysis
11.
Innovations (Phila) ; 8(5): 371-5, 2013.
Article in English | MEDLINE | ID: mdl-24346587

ABSTRACT

OBJECTIVE: The left atrial appendage (LAA) is the source of 90% of thrombi in patients with atrial fibrillation. Our double LAA ligation (LLAA) technique was shown to be 96% successful in a small study. However, the outcomes of these patients have yet to be compared with a set of nonligated patients. METHODS: From 2005 to 2012, a total of 808 patients received LAA using our double ligation technique using both a polydioxanone (PDS) II endosnare and a running 4-0 Prolene pledgeted suture. The 30-day outcomes of these patients were compared with that of nonligated patients. Fifty-six of the ligated patients had a postoperative transesophageal echocardiography (TEE). An echocardiographer reviewed the follow-up TEEs for LAA remnant and/or residual flow into the LAA using color Doppler imaging. The patients with LAA flow and/or remnant depth of 1 cm or greater were deemed to have an unsuccessful exclusion. RESULTS: The ligated group had a trend of less postoperative atrial fibrillation (19.4% vs 22.9%, P = 0.07) and an overall significantly lower in-hospital mortality (0.7% vs 3.0%, P < 0.001) and lower 30-day mortality (0.7% vs 3.4%, P < 0.0001). The LAA was successfully excluded in 53 (94.7%) of the 56 patients with TEE. CONCLUSIONS: Double LAA ligation correlates with lower rates of in-hospital and 30-day mortality. This advantage comes without an increase in perioperative complications. This technique can easily be performed off or on pump, is very reproducible, and comes at a very low cost compared with LAA occlusion devices. Stroke has a multifactorial etiology; successful LLAA removes one potential source of thrombi perioperatively and in the long-term.


Subject(s)
Atrial Appendage/surgery , Echocardiography, Transesophageal , Pericardium/surgery , Aged , Atrial Appendage/diagnostic imaging , Atrial Fibrillation/surgery , Echocardiography, Transesophageal/methods , Female , Humans , Ligation/methods , Male , Middle Aged , Pericardium/diagnostic imaging , Suture Techniques/instrumentation , Sutures , Treatment Outcome
12.
Genomics ; 101(6): 313-7, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23462555

ABSTRACT

Clopidogrel is an oral antiplatelet pro-drug prescribed to 40 million patients worldwide who are at risk for thrombotic events or receiving percutaneous coronary intervention (PCI). However about a fifth of patients treated with clopidogrel do not respond adequately to the drug. From a cohort of 105 patients on whom we had functional data on clopidogrel response, we used ultra-high throughput sequencing to assay mutations in CYP2C19 and ABCB1, the two genes genetically linked to respond. Testing for mutations in CYP2C19, as recommended by the FDA, only correctly predicted if a patient would respond to clopidogrel 52.4% of the time. Similarly, testing of the ABCB1 gene only correctly foretold response in 51 (48.6%) patients. These results are clinically relevant and suggest that until additional genetic factors are discovered that predict response more completely, functional assays are more appropriate for clinical use.


Subject(s)
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics , Coronary Artery Bypass , DNA Mutational Analysis/methods , Platelet Aggregation Inhibitors/pharmacology , Ticlopidine/analogs & derivatives , ATP Binding Cassette Transporter, Subfamily B , Aged , Aryl Hydrocarbon Hydroxylases/genetics , Blood Platelets/physiology , Case-Control Studies , Clopidogrel , Cytochrome P-450 CYP2C19 , Drug Resistance/genetics , Female , Genetic Association Studies , Heart Diseases/blood , Heart Diseases/therapy , Humans , Male , Middle Aged , Mutation , Platelet Aggregation/drug effects , Platelet Aggregation/genetics , Platelet Aggregation Inhibitors/therapeutic use , Platelet Function Tests , Ticlopidine/pharmacology , Ticlopidine/therapeutic use
13.
Interact Cardiovasc Thorac Surg ; 17(1): 96-102, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23537850

ABSTRACT

OBJECTIVES: Prior studies have found that cardiac surgery patients receiving blood transfusions are at risk for increased mortality and morbidity following surgery. It is not clear whether this increased risk occurs across all haematocrit (HCT) levels. The goal of this study was to compare operative mortality in propensity-matched cardiac surgery patients based on stratification of the preoperative HCT levels. METHODS: Between 1 August 2004 and 30 June 2011, 3516 patients had cardiac surgery. One thousand nine hundred and twenty-two (54.5%) required blood transfusion during or after surgery. A propensity score for transfusion was developed based on 22 baseline variables. One thousand seven hundred and fourteen patients were matched: 857 in the transfusion group (TG) and 857 in the non-transfused control group (CG). Univariate analyses demonstrated that, after propensity matching, the groups did not differ on any baseline factors included in the propensity model. Operative mortality was defined as death within 30 days of surgery. Preoperative HCT was stratified into four groups: <36, 36-39, 40-42 and ≥ 43. RESULTS: For HCT <36%, 30-day mortality was higher in the TG than that in the CG (3.0 vs 0.0%). For HCT 36-39, operative mortality was similar between TG (1.1%, N = 180) and CG (0.8%, N = 361; P = 0.748). For HCT 40-42, operative mortality was significantly higher in the TG compared with that in the CG (1.9 vs 0%, N = 108 and 218, respectively; P = 0.044). For HCT of ≥ 43, there was a trend towards higher operative mortality in the TG vs the CG (2.0 vs 0%, N = 102 and 152, respectively; P = 0.083). Other surgical complications followed the same pattern with higher rates found in the transfused group at higher presurgery HCT levels. HCT at discharge for the eight groups were similar, with an average of 29.1 ± 1.1% (P = 0.117). CONCLUSIONS: Our study indicates that a broad application of blood products shows no discernible benefits. Furthermore, patients who receive blood at all HCT levels may be placed at an increased risk of operative mortality and/or other surgical complications. Paradoxically, even though patients with low HCTs theoretically should benefit the most, transfusion was still associated with a higher complication and mortality rate in these patients. Our results indicate that blood transfusion should be used judiciously in cardiac surgery patients.


Subject(s)
Blood Loss, Surgical/prevention & control , Cardiac Surgical Procedures/adverse effects , Postoperative Hemorrhage/therapy , Transfusion Reaction , Aged , Aged, 80 and over , Biomarkers/blood , Blood Loss, Surgical/mortality , Blood Transfusion/mortality , Cardiac Surgical Procedures/mortality , Chi-Square Distribution , Female , Hematocrit , Hemoglobins/metabolism , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Patient Selection , Postoperative Hemorrhage/blood , Postoperative Hemorrhage/etiology , Postoperative Hemorrhage/mortality , Propensity Score , Retrospective Studies , Risk Assessment , Risk Factors , Treatment Outcome
14.
Interact Cardiovasc Thorac Surg ; 15(3): 371-6, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22665381

ABSTRACT

OBJECTIVES More elderly patients (>80 years of age) are being referred for aortic valve replacement (AVR) with or without CABG. Current risk stratification models may not accurately predict the preoperative risk in these patients. We sought to determine which perioperative variables were relevant in determining short-term (30-day to in-hospital) outcomes in our intuition's series of consecutive AVR and AVR+CABG surgeries. We constructed a novel variable, patient-prosthesis mismatch (PPM) in the presence of diminished functional status (NYHA) classification, and studied its role as a predictor of mortality risk. METHODS From 2006 to 2010, 509 patients undergoing AVR or AVR+CABG were evaluated. We created four groups based on the age and procedure (AVR >80, AVR+CABG >80, AVR <80 and AVR+CABG <80). PPM was defined as a calculated effective orifice area index value of ≤ 0.85, and it was calculated from manufacturer-generated charts. In-hospital and 30-day outcomes were assessed using the Chi-square and logistic regression analyses. RESULTS Overall observed 30-day mortality for all groups was lower (n = 8, 1.6%) than the STS-predicted mortality. Reoperation and PPM+NYHA class III-IV were associated with short-term mortality, but age >80 years was not. Octogenarians referred for surgery often had advanced heart failure. CONCLUSIONS Overall, short-term outcomes after AVR with or without CABG were excellent and lower than predicted by the STS model. The low risk of AVR with CABG supports the consideration for earlier surgical referral and intervention for patients with a high likelihood of aortic stenosis progression before the onset of advanced heart failure ensues, regardless of the age. This should help further decrease the already very low mortality observed in these series. Efforts to avoid PPM in the setting of advanced heart failure may improve short-term results in this subset of patients.


Subject(s)
American Heart Association , Aortic Valve Stenosis/surgery , Heart Failure/surgery , Heart Valve Prosthesis/classification , Prosthesis Failure , Age Factors , Aged , Aged, 80 and over , Aortic Valve Stenosis/complications , Aortic Valve Stenosis/mortality , Female , Follow-Up Studies , Heart Failure/etiology , Heart Failure/mortality , Hospital Mortality/trends , Humans , Male , New York , Prospective Studies , Risk Factors , Survival Rate/trends , United States/epidemiology
15.
J Invasive Cardiol ; 24(2): 49-52, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22294531

ABSTRACT

BACKGROUND: The current standard of care is to delay coronary surgery 5-7 days after clopidogrel exposure to prevent bleeding complications. We sought to determine the utility of an objective tool (ie, the VerifyNow assay) to measure platelet inhibition (PI) in patients receiving preoperative clopidogrel prior to off-pump coronary artery bypass grafting surgery (OPCABG). PATIENTS AND METHODS: Between June 2007 and July 2009, a total of 482 isolated OPCABG procedures were performed at our institution. In 160 patients, the VerifyNow assay results were used to determine timing of the OPCABG. These patients were compared to the remaining 322 patients. We divided the cohort into 4 subgroups: Group 1 patients (n = 205) were not taking clopidogrel; Group 2 patients (n = 117) were taking clopidogrel, but the test was not performed; Group 3 patients (n = 122) were taking clopidogrel and had a preoperative PI result of ≤20%; and Group 4 patients (n = 38) had ≥21% preoperative PI. RESULTS: Demographic and clinical factors were compared in all groups. The median waiting time for surgery from the last dose of clopidogrel was 6 days for the control groups and 3 days for the groups where the test was performed (P<.001). Reoperation for bleeding occurred most often in Group 4 (7.9%; P=.003). Blood utilization was lower in Group 1 (24.4%) than in Groups 2 (34.2%), 3 (40.2%), or 4 (55.3%) (P<.001). Major complications and postoperative length of stay were similar in all groups. CONCLUSIONS: Utilization of a PI tool in the preoperative assessment of OPCABG patients exposed to clopidogrel can provide valuable information to guide the timing of coronary surgery and may lead to a decrease in reoperation for bleeding and blood usage.


Subject(s)
Blood Coagulation Tests , Blood Loss, Surgical/prevention & control , Coronary Artery Bypass, Off-Pump , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation/drug effects , Ticlopidine/analogs & derivatives , Adenosine Diphosphate/pharmacology , Aged , Blood Transfusion , Clopidogrel , Female , Humans , Male , Postoperative Complications , Preoperative Care , Reoperation , Ticlopidine/administration & dosage
16.
Eur J Cardiothorac Surg ; 41(4): 770-5; discussion 776, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22290908

ABSTRACT

OBJECTIVES: Bilateral internal mammary arteries (BIMA) remains widely underutilized in coronary artery bypass grafting (CABG). Although prior research has demonstrated a long-term benefit of the use of BIMA over left internal mammary artery (LIMA)-only, validation of these results is lacking in a contemporary surgical experience. We compared complications and survival at 17-year follow-up in a large series of consecutive CABG patients from a single institution that underwent BIMA grafting with a propensity-matched group where LIMA only was used. METHODS: Propensity scores representing the estimated probabilities of patients receiving either BIMA or LIMA alone were developed based on 22 observed baseline covariates in a logistic regression model with procedure group as the dependent variable. The nearest-neighbour-matching algorithm with Greedy 5-1 Digit Matching was used to produce two patient cohorts of 928 patients each balanced for baseline factors. We compared 30-day morbidity and mortality, as well as long-term survival at 5-year intervals up to 17-year follow-up. RESULTS: In-hospital and 30-day mortality was 0.8% for the BIMA group and 1.1% for the LIMA-saphenous vein grafting (SVG). No significant difference was found in complications, mortality and/or length-of-stay between these two groups. Off-pump was done in 48.9% of BIMA cases and 51.3% of LIMA cases. Regardless of the types of grafts used, on-pump patients were more likely to have postoperative permanent strokes and longer postoperative lengths of stay. Use of the BIMA over LIMA-only had a statistically significant impact conferring a 10% survival advantage at 10-year and 18% at 15-year follow-up. The Kaplan-Meier survival curves comparing off-/on-pump BIMA and off-/on-pump LIMA-SVG patients demonstrated a 22% survival advantage for off-pump BIMA patients when compared with on-pump LIMA-SVG patients at 15-year follow-up. CONCLUSIONS: Perioperative complications do not increase with the use of BIMAs. Long-term survival is optimized with off-pump CABG and BIMA grafting. The low morbidity and mortality rates in this series are likely due to the continuous evolution of technology and the adoption of less invasive options for CABG patients. A more widespread use of BIMAs in CABG patients would continue to improve the overall excellent short- and long-term results of this operation.


Subject(s)
Coronary Disease/surgery , Internal Mammary-Coronary Artery Anastomosis/methods , Age Factors , Aged , Body Mass Index , Coronary Artery Bypass, Off-Pump/adverse effects , Coronary Artery Bypass, Off-Pump/methods , Coronary Artery Bypass, Off-Pump/mortality , Coronary Disease/mortality , Female , Follow-Up Studies , Humans , Internal Mammary-Coronary Artery Anastomosis/adverse effects , Internal Mammary-Coronary Artery Anastomosis/mortality , Kaplan-Meier Estimate , Male , Middle Aged , New Jersey/epidemiology
17.
J Thorac Cardiovasc Surg ; 143(2): 287-93, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22104669

ABSTRACT

OBJECTIVES: The present study examined the relationship between hospital and surgeon coronary artery bypass grafting procedural volume, mortality, morbidity, and National Quality Forum care processes in a university-based community hospital quality improvement program. METHODS: The study population consisted of 2218 consecutive patients undergoing isolated coronary artery bypass grafting from 2007 to 2009 in a university-based quality improvement program that emphasizes involvement of all surgeons in the academic quality endeavor. The endpoints included operative mortality, major morbidity, and National Quality Forum-endorsed process measures as defined by the Society of Thoracic Surgeons. The procedural volume was analyzed as a categorical and continuous variable using general estimating equations, which accounted for clustering effects and which were adjusted for Society of Thoracic Surgeons risk scores and the propensity for operation in a low- versus high-volume program. RESULTS: The annual program volume ranged from 67 to 292 (median, 136; interquartile range, 88-224) and surgeon volume from 1 to 124 (median, 58; interquartile range, 30-89). The mortality rate among the hospitals was 0.47% to 2.23% (0.8% overall), and the observed/expected mortality ranged from 0 to 1.20 (0.41 overall). When comparing low-volume (<200 cases/year) and high-volume centers, no difference was found in the mortality (odds ratio [OR], 1.08; 95% confidence interval [CI], 0.46-2.54, P = .85), morbidity (OR, 1.34; 95% CI, 0.73-2.43), or any of the medication process measures. No difference was found in mortality (OR, 1.59; 95% CI, 0.81-3.13; P = .18), morbidity (OR, 1.20; 95% CI, 0.86-1.66; P = .28), or medication failure (OR, 0.57, 95% CI, 0.3-1.10; P = .10) between the high- and low-volume surgeons (<87). After adjustment for both the Society of Thoracic Surgeons risk score and the propensity score, no association was found for either hospital or surgeon volume with mortality or morbidity. However, a lack of compliance with National Quality Forum measures was highly predictive of morbidity (OR, 1.51; 95% CI, 1.18-1.93; P = .001), regardless of volume, even after adjustment for predicted risk. CONCLUSIONS: In the setting of a university-based community hospital quality improvement program, excellent surgical results can consistently be obtained even in relatively low-volume programs. The surgical outcomes were not associated with program or surgeon volume, but were directly correlated with the focus on quality as manifested by compliance with evidence-based quality standards. Meaningful university affiliation might represent a new quality paradigm for cardiac surgery in the community hospital setting.


Subject(s)
Community Networks/standards , Coronary Artery Bypass/standards , Hospitals, Community/standards , Hospitals, University/standards , Outcome and Process Assessment, Health Care/standards , Quality Improvement/standards , Quality Indicators, Health Care/standards , Aged , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/mortality , Female , Hospital Mortality , Humans , Logistic Models , Male , Middle Aged , New York City , Odds Ratio , Postoperative Complications/etiology , Postoperative Complications/mortality , Program Evaluation , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome
19.
Rev Cardiovasc Med ; 12 Suppl 1: S40-6, 2011.
Article in English | MEDLINE | ID: mdl-22080987

ABSTRACT

Antiplatelet therapy is widely accepted in the contemporary management of patients with coronary syndromes. Effective platelet inhibition can cause an increased risk of bleeding, which is more evident when patients are referred to surgical coronary revascularization. The cardiac surgeon should be familiar with all new antiplatelet drugs. In this article we compile the latest information about antiplatelet therapy and its impact on cardiac surgery.


Subject(s)
Coronary Artery Bypass/adverse effects , Heart Diseases/therapy , Platelet Aggregation Inhibitors/adverse effects , Postoperative Hemorrhage/etiology , Blood Platelets/drug effects , Heart Diseases/blood , Heart Diseases/drug therapy , Heart Diseases/surgery , Humans , Platelet Function Tests , Postoperative Hemorrhage/blood , Postoperative Hemorrhage/prevention & control , Predictive Value of Tests , Risk Assessment , Risk Factors
20.
J Heart Valve Dis ; 19(1): 149-51, 2010 Jan.
Article in English | MEDLINE | ID: mdl-20329501

ABSTRACT

The case is reported of a patient who underwent aortic valve replacement (AVR) in 1969 and received a (first-generation) Björk-Shiley Delrin valve. Forty years later, the patient presented to the authors' hospital in congestive heart failure and with echocardiographic evidence of severe stenosis and mild aortic regurgitation. The patient underwent a redo sternotomy and AVR with a bioprosthesis. On gross examination, the explanted 40-year-old mechanical valve appeared intact.


Subject(s)
Heart Valve Prosthesis , Aortic Valve Stenosis/surgery , Echocardiography, Transesophageal , Heart Failure/etiology , Heart Failure/physiopathology , Heart Valve Prosthesis Implantation , Humans , Male , Middle Aged , Prosthesis Design , Prosthesis Fitting , Reoperation , Stroke Volume , Time Factors
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