ABSTRACT
Combined investigation in patients with maniac-depressive psychosis revealed the close relation of depression to the direction in which changes of central and peripheral links of bodily neurohumoral system occur. With even some of the homeostatic functions normalized as a result of an adaptogenic effect of hormonal and biologically active drugs (triiodothyronine, thyrotropin, insulin, Sodium succinate, pituitrin (vasopressin), somatotropin, retabolil), the depressive affect weakened or disappeared. Combined therapy of depression is recommended comprising antidepressants and some hormonal drugs promoting the adaptation processes of the body.
Subject(s)
Bipolar Disorder/drug therapy , Hormones/therapeutic use , Succinates/therapeutic use , Action Potentials/drug effects , Adult , Bipolar Disorder/etiology , Bipolar Disorder/physiopathology , Brain/drug effects , Brain/physiopathology , Catecholamines/metabolism , Humans , Insulin/therapeutic use , Male , Nandrolone/analogs & derivatives , Nandrolone/therapeutic use , Nandrolone Decanoate , Pituitary Hormones/therapeutic use , Succinic Acid , Triiodothyronine/therapeutic useSubject(s)
Stress, Psychological/drug therapy , Vasopressins/therapeutic use , Adaptation, Physiological/drug effects , Animals , Brain/drug effects , Brain/physiopathology , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Male , Rats , Stress, Psychological/blood , Stress, Psychological/physiopathologySubject(s)
Antidepressive Agents, Tricyclic/therapeutic use , Depressive Disorder/drug therapy , Adult , Autonomic Nervous System/drug effects , Catecholamines/urine , Dark Adaptation/drug effects , Depressive Disorder/etiology , Depressive Disorder/physiopathology , Drug Evaluation , Electroencephalography , Female , Higher Nervous Activity/drug effects , HumansABSTRACT
The age-related features of the sympatheticoadrenal homeostatic system identified in healthy subjects affect the pathogenesis and the clinical picture of depressions in old age. Sympatheticotonia , the stimulation of catecholamine synthesis, particularly of noradrenaline synthesis, contribute to the development of anxiety and agitation states in manic-depressive patients. Patients with involutional depression are characterized by the heterogeneous pattern of the functional changes in the body. This feature differentiates the above disorder from manic-depressive psychosis. Despite the anxiety affect, the patients mostly exhibit the synchronous EEG and the absence of any changes in blood and urinary noradrenaline. The central and peripheral changes in atherosclerotic depression reflect the on-going pathological process.
Subject(s)
Biogenic Amines/analysis , Bipolar Disorder/physiopathology , Cardiovascular System/physiopathology , Depressive Disorder/physiopathology , Nervous System/physiopathology , Adult , Age Factors , Aged , Autonomic Nervous System/physiopathology , Brain/physiopathology , Depressive Disorder, Major/physiopathology , Electroencephalography , Female , Galvanic Skin Response/physiology , Humans , Male , Middle AgedABSTRACT
It was established that young patients in the depressive phase of manic-depressive psychosis (MDP) display the homogeneity of functional changes at various levels of the body auto-regulation system. In advanced age (45-65 years), due to uneven involutional changes, the body exhibits an increase in the activity of the central and, particularly peripheral links of the sympathetico-adrenal homeostatic system, which explains a considerable elevation in the number of patients with pronounced anxious symptomatology and hypersympathicotonia at the periphery. High affective tension with agitation phenomena in patients with the disease onset in advanced age is maintained by fairly high blood levels of catecholamines (particularly noradrenaline) due to the stimulation of their synthesis.
