ABSTRACT
BACKGROUND: In children with acute myeloid leukemia, the incidence of hyperleukocytosis is 5-33%. Patients with AML and hyperleukocytosis have a higher early mortality rate than patients with nonhyperleukocytic AML because of the increased risk of severe pulmonary and neurologic complications. Leukapheresis provides rapid cytoreduction and reduces early mortality rates. CASE PRESENTATION: In this report, we present a case with microcirculatory failure of upper extremities as a rare symptom of hyperleukocytic AML M4 at initial presentation. CONCLUSIONS: Early diagnosis and treatment of patients with AML admitted to emergency services with these symptoms is too important to prevent from loss of extremities. Most of the complications of hyperleukocytosis can be reversible with early treatment.
Subject(s)
Leukemia, Myeloid, Acute , Leukostasis , Child , Humans , Leukostasis/etiology , Leukostasis/prevention & control , Microcirculation , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/therapy , Leukemia, Myeloid, Acute/diagnosis , Leukapheresis , Upper Extremity , Leukocytosis/therapyABSTRACT
BACKGROUND: SARS-CoV-2 mostly affects the respiratory system. Some studies have reported neurological disorders associated with SARS-CoV-2. Despite an increase in reported instances, encephalitis caused by COVID-19 infection is still poorly understood. CASE: We reported a rare presentation of SARS-CoV-2 in a 15-year-old patient. He had a fulminant course with encephalitis. He had mild symptoms of a COVID-19 infection five months ago and recovered without any sequel. Despite appropriate treatment, the patient had a devastating course. CONCLUSIONS: This was a severe presentation of SARS-CoV-2 with central nervous system manifestations.
