Robust Antiferromagnetic FeRh Films on Mica.

FeRh shows an antiferromagnetic to ferromagnetic phase transition above room temperature, which permits its use as an antiferromagnetic memory element. However, its antiferromagnetic order is sensitive to small variations in crystallinity and composition, challenging its integration into flexible devices. Here, we show that flexible FeRh films of high crystalline quality can be synthesized by using mica as a substrate, followed by a mechanical exfoliation of the mica. The magnetic and transport data indicate that the FeRh films display a sharp antiferromagnetic to ferromagnetic phase transition. Magnetotransport data allow for the observation of two distinguishable resistance states, which are written after a field-cooling procedure. It is shown that the memory states are robust under the application of magnetic fields of up to 10 kOe.

The emergent role of digital technologies in the context of humanitarian supply chains: a systematic literature review.

The role of digital technologies (DTs) in humanitarian supply chains (HSC) has become an increasingly researched topic in the operations literature. While numerous publications have dealt with this convergence, most studies have focused on examining the implementation of individual DTs within the HSC context, leaving relevant literature, to date, dispersed and fragmented. This study, through a systematic literature review of 110 articles on HSC published between 2015 and 2020, provides a unified overview of the current state-of-the-art DTs adopted in HSC operations. The literature review findings substantiate the growing significance of DTs within HSC, identifying their main objectives and application domains, as well as their deployment with respect to the different HSC phases (i.e., Mitigation, Preparedness, Response, and Recovery). Furthermore, the findings also offer insight into how participant organizations might configure a technological portfolio aimed at overcoming operational difficulties in HSC endeavours. This work is novel as it differs from the existing traditional perspective on the role of individual technologies on HSC research by reviewing multiple DTs within the HSC domain.

A rise in T3/T4 ratio reduces the growth of prostate tumors in a murine model.

Thyroxine (T4) promotes cell proliferation and tumor growth in prostate cancer models, but it is unknown if the increase in the triiodothyronine (T3)/T4 ratio could attenuate prostate tumor development. We assessed T3 effects on thyroid response, histology, proliferation, and apoptosis in the prostate of wild-type (WT) and TRAMP (transgenic adenocarcinoma of the mouse prostate) mice. Physiological doses of T3 were administered in the drinking water (2.5, 5 and 15 µg/100 g body weight) for 6 weeks. None of the doses modified the body weight or serum levels of testosterone, but all of them reduced serum T4 levels by 50%, and the highest dose increased the T3/T4 ratio in TRAMP. In WT, the highest dose of T3 decreased cyclin D1 levels (immunohistochemistry) but did not modify prostate weight or alter the epithelial morphology. In TRAMP, this dose reduced tumor growth by antiproliferative mechanisms independent of apoptosis, but it did not modify the intraluminal or fibromuscular invasion of tumors. In vitro, in the LNCaP prostate cancer cell line, we found that both T3 and T4 increased the number of viable cells (Trypan blue assay), and only T4 response was fully blocked in the presence of an integrin-binding inhibitor peptide (RGD, arginine-glycine-aspartate). In summary, our data show that the prostate was highly sensitive to physiological T3 doses and suggest that in vivo, an increase in the T3/T4 ratio could be associated with the reduced weight of prostate tumors. Longitudinal studies are required to understand the role of thyroid hormones in prostate cancer progression.

Celulitis recurrente importada, la importancia de la anamnesis / Imported recurrent cellulitis, the relevance of anamnesis

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Assessing allergenicity in urban parks: A nature-based solution to reduce the impact on public health.

Urban parks play a key role in the provision of ecosystem services, actively participating in improving the quality of life and welfare of local residents. This paper reports on the application of an index designed to quantify the allergenicity of urban parks in a number of Spanish cities. The index, which records biological and biometric parameters for the tree species growing there, classifies parks in terms of the risk they pose for allergy sufferers, graded as null, low, moderate or high. In this initial phase, the index was applied to 26 green areas in 24 Spanish cities; green areas varied in type (urban park, historical or modern garden, boulevard, square or urban forest), size 1-100 ha), geographical location, species richness, number of trees and tree density (number of trees / ha.). The data obtained were used to calculate the percentage of allergenic species in each park, which varied between 17-67%; density ranged from 100 to 300 trees/ha. The index values recorded ranged from a minimum of .07 to a maximum of .87; a significant correlation was found between index value and both number of trees and tree density. Taking an index value of .30 as the threshold considered sufficient to trigger allergy symptoms in the sensitive population, 12 of the parks studied may be regarded as unhealthy at any time of the year. Corrective measures to mitigate the impact of pollen emissions include the implementation of nature-based solutions at various levels: planning and design, handling and management, and strengthening of urban green-infrastructure elements. The index proved to be a useful tool for environmental analysis, and complies with the principles of portability and scalability central to current and horizon scientific research.

Paraneoplastic autoimmune multiorgan syndrome (paraneoplastic pemphigus) with unusual manifestations and without detectable autoantibodies.

We describe a patient with paraneoplastic autoimmune multiorgan syndrome (PAMS) secondary to a lymphoblastic T- cell lymphoma who presented with a lichenoid dermatitis and vitiligo, later developing bronchiolitis obliterans and autoimmune hepatitis. Notably, he had no detectable autoantibodies. The development of vitiligo and autoimmune hepatic involvement probably indicate a role for cytotoxic T- cell lymphocytes in the pathogenesis of this syndrome.

Expresión cutánea atípica de leishmaniasis visceral en la infección por VIH / Atypical cutaneous expression of visceral leishmaniasis in HIV infection

Presentamos un caso de leishmaniasis visceral asociada a infección por virus de la inmunodeficiencia humana (VIH). Un rebrote sistémico de la leishmaniasis se manifestó con lesiones excepcionalmente atípicas en nuestro medio, en forma de placas infiltradas en labios y zona perioral como única afectación cutaneomucosa. La histología mostraba un infiltrado histiocitario difuso cargado de leishmanias. El cuadro cutáneo cedió tras un ciclo de antimoniales en dosis elevadas (AU)

Medición de la prevalencia de la dermatitis atópicaen una población escolar madrileña / Measuring the prevalence of atopic dermatitis in a school-age population in Madrid

Fundamento: El Grupo de Trabajo para la Dermatitis Atópica del Reino Unido (GTRUDA) ha desarrollado un cuestionario diagnóstico que ha sido validado en sus versiones inglesa y rumana tanto en medio hospitalario como extrahospitalario. Objetivo: Nuestro objetivo era desarrollar una versión española de dicho cuestionario y emplearla para conocer la frecuencia de la enfermedad en la población escolar general del Área sanitaria XI de Madrid. Resultados: La validación en medio hospitalario demostró una sensibilidad del 76,5% con un intervalo de confianza del 95% (IC 95%) del 66,8-84,1%. La especificidad fue del 90,4% (IC 95%: 83,8-94,6%), el valor predictivo positivo (VPP) del 85,7% (IC 95%: 76,4-91,8%) y el valor predictivo negativo (VPN) del 83,6% (IC 95%: 76,3-89%). Cinco colegios fueron seleccionados aleatoriamente y la totalidad de sus alumnos invitados a participar en el estudio. Se examinaron 874 niños (porcentaje de respuesta: 62,9%). La prevalencia de período de un año fue del 9,95% (7,97; 11,94). La prevalencia puntual fue del 7.09% (5,39; 8,80). En el grupo de edad de los 3 a los 7 años la prevalencia de período de un año era del 11,2%, en el grupo de 8 a 12 años del 10,3% y en el grupo de 13 a 17 años del 6,9%. No hubo diferencias estadísticamente significativas al comparar ambos sexos, por edades ni por tipo de colegio (público/privado). Se validó el resultado ofrecido por el cuestionario con el diagnóstico clínico de un dermatólogo en una submuestra de 130 pacientes. Los resultados obtenidos fueron: sensibilidad, 63,6% (31,6; 87,6); especificidad, 96,7% (91,4; 99,0); VPP, 63,6% (31,6; 87,6); VPN, 96, 7% (91,4; 99,0). Conclusiones: Consideramos que la versión española que hemos desarrollado del cuestionario diagnóstico es útil y con buenos resultados, en la línea de los publicados por otros grupos (AU)

Recomendaciones de GESIDA/Plan Nacional sobre el Sida respecto al diagnóstico y tratamiento del sarcoma de Kaposi y el cáncer de cérvix uterino en pacientes infectados por el virus de la inmunodeficiencia humana / Recommendations of GESIDA/Spanish National Plan of AIDS on diagnosis and treatment of Kaposi´s sarcoma and cervical cancer in HIV-infected patients

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Intertrigo inguinal / Inguinal intertrigo

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