ABSTRACT
Two kinds of tumor cell death--necrosis and apoptosis--were compared upon electron-microscopic study of rectal cancer cells apoptosis before and after the tumor irradiation. Apoptosis in nonirradiated tumor occurs more commonly along its periphery, advanced tumor stages being characterized by apoptosis presentation with phagocytized apoptotic bodies. Upon irradiation the number of apoptotic cells in the tumor tends to increase whereas morphologic pattern of apoptosis remains unchanged.
Subject(s)
Rectal Neoplasms/radiotherapy , Cell Survival/radiation effects , Humans , Microscopy, Electron , Necrosis , Phagocytosis/radiation effects , Rectal Neoplasms/pathology , Rectal Neoplasms/ultrastructureABSTRACT
Two types of cells (dark and clear) with secretory granules in the cytoplasm were identified in these tumors. No specific ultrastructural features that would distinguish tumors differing in the degree of maturity were noted in the cells.
Subject(s)
Head and Neck Neoplasms/ultrastructure , Paraganglioma, Extra-Adrenal/ultrastructure , Adult , Aged , Carotid Artery, Internal , Chronic Disease , Female , Humans , Male , Microscopy, Electron , Middle Aged , Oropharyngeal Neoplasms/ultrastructureABSTRACT
The clinical and morphological pictures of retroperitoneal malignant fibrous histiocytoma in a woman of 53 and a man of 31 are described. The female patient was observed for 7 years and 3 times underwent surgical removal of multiple tumor nodes from the abdominal cavity. The man had a wide spread of tumor into the organs of the abdominal cavity with a rapid death.
Subject(s)
Histiocytoma, Benign Fibrous/pathology , Neoplasm Recurrence, Local/pathology , Retroperitoneal Neoplasms/pathology , Adult , Female , Histiocytoma, Benign Fibrous/ultrastructure , Humans , Male , Microscopy, Electron , Middle Aged , Neoplasm Recurrence, Local/ultrastructure , Retroperitoneal Neoplasms/ultrastructureABSTRACT
The ultrastructure of blood and lymph capillaries of rectal adenocarcinoma was studied before and after pre-operation radiation therapy. The walls of blood capillaries of the tumor were formed by endothelial cells, basal membrane, and pericytes, while those of lymph capillaries by endothelial cells alone. After irradiation of the tumor at a dose of 20 Gr the total architechtonics of the vessel wall of blood and lymph capillaries was retained, but the lumen of many capillaries became smaller, and connections between endotheliocytes weaker. Radiation changes of endothelial cells of the vessels of both types are similar and manifest as swelling, vacuolation of organelles of the cytoplasm, accumulation of lipid drops, distention of tubules and cisterns.
Subject(s)
Adenocarcinoma/ultrastructure , Capillaries/ultrastructure , Lymph Nodes/ultrastructure , Rectal Neoplasms/ultrastructure , Adenocarcinoma/blood supply , Adenocarcinoma/radiotherapy , Humans , Microscopy, Electron , Rectal Neoplasms/blood supply , Rectal Neoplasms/radiotherapyABSTRACT
The Normal mucous membrane and tumours of the large intestine and the rectum were studied electron microscopically. Five known cell types were found in normal intestinal mucosa: intestinal epitheliocyte with striated border, goblet enterocyte, intestinal argentaffinocyte, enterocyte with acidofilic granules, borderless enterocyte. Adenocarcinoma cells differentiate in the direction of 3 cell types: intestinal epitheliocytes, goblet enterocytes, and borderless enterocytes. The level of differentiation in different cells varies considerably.
