ABSTRACT
Macula was examined using fundus photo and OCT in 115 patients with choroidal melanoma located distant from macula before and after brachytherapy. Macular changes were revealed in 24,35% of irradiated eyes. Nevertheless primary radiation-induced maculopathy after ruthenium plaque radiotherapy occurred in 9,59% only. In the rest of cases (10,43%) macular changes were present before brachytherapy. The causes of their development were choroidal melanoma (tumor-associated maculopathy) and AMD.
Subject(s)
Brachytherapy/adverse effects , Choroid Neoplasms/radiotherapy , Macula Lutea/pathology , Macula Lutea/radiation effects , HumansABSTRACT
Distant macular changes were revealed in 21 of 28 patients with intraocular melanoma. In 13 eyes maculopathy was very distant from choroidal melanoma (CM), in 4 cases the tumor was located preequatorially and in 9 patients in the posterior fundus beyond the macular zone. In 8 patients bilateral AMD was found along with CM. Revealed changes are considered to be tumor-associated sign of progressing CM. Association of AMD and CM should be considered as a combination of two distinct conditions, when CM disturbs hematoretinal barrier and thus leads to AMD progression.
