ABSTRACT
Wound healing activity of 20 different means of conservative treatment of radiation burns was studies in the experiments on the rats subjected to local ß-radiation (at a dose of 60 Gy) and combined radiation damage (ß-radiation at a dose of 60 Gy and the whole-body γ-irradiation at a dose of 4 Gy). It was found that reparative processes in the irradiated,skin in the case of the local radiation injuries are most effectively accelerated by ointments Biopin, Panthenol-Ratiopharm, IL-1ß and Iruksol; Dimexidum solution; aerosols Olazol, Gipozol and Polkortolon; wound coverings Procell-super and Selenopol. Ointments containing IL-1ß, Dimexidum solution, aerosols and wound coverings have a healing effect in the case of combined radiation injury.
Subject(s)
Burns/drug therapy , Radiation Injuries, Experimental/drug therapy , Radiation, Ionizing , Radiation-Protective Agents/therapeutic use , Skin/injuries , Wound Healing/drug effects , Aerosols , Animals , Beta Particles/adverse effects , Burns/etiology , Gamma Rays/adverse effects , Male , Ointments , Radiation Dosage , Radiation-Protective Agents/administration & dosage , Rats , Skin/drug effects , Whole-Body IrradiationABSTRACT
The study was aimed at experimental evaluating the efficacy of experimental wound collagen coverings "Sangvikol", "Gemasept", "Kolotsil" and "Biatravm" for treatment of deep radiation burns which form at combined radiation injures. The combined radiation injures were modeled by consecutive local X-ray radiation of skin at a dose of 120 Gy and the total whole body gamma-irradiation from a source of 137Cs at a dose of4 Gy. It is established that wound collagen coverings are well modeled on a wound, absorb excess exudate, maintain optimum humidity in a wound; protect a wound from infection, and medicinal fillers contribute to the activation of reparative processes in the irradiated skin. Wound coverings do not require frequent dressings and more effectively prevent post-radiation depression recovery processes in irradiated skin than ointments.
Subject(s)
Burns/drug therapy , Radiation Injuries/drug therapy , Radiation-Protective Agents/administration & dosage , Wound Healing/drug effects , Animals , Burns/pathology , Gamma Rays , Humans , Male , Radiation Injuries/pathology , Rats , Whole-Body Irradiation , Wound Healing/radiation effectsABSTRACT
SHR mice with intracranial transplanted lymphosarcoma LIO-1 received a single intraperitoneal gemcitabine injection in maximal tolerated dose of 25 mg/kg or single maximal tolerated oral dose of lomustine, 50 mg/kg. Compared to control group gemcitabine injection increased the mice lifespan 1.4-fold (p < 0,01) and oral lomustine 1.6-fold (p < 0,01). The median lifespan of the mice receiving both gemcitabine and lomustine in maximal dose underwent a significant 3.3-fold increase (p < 0,01) compared to controls (2.4-fold compared to gemcitabine and 2.1-fold compared to lomustine group). Combined therapy didn't cause an increase of toxicity.
