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1.
Scand J Psychol ; 63(4): 393-404, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35353913

ABSTRACT

The mass media portrayal of a muscular body type ideal has been increasingly tied to men's body image dissatisfaction. We examined the role of self-determination theory's intrinsic life goals within this body image ideal and its potential as a moderator of this dissatisfaction. We first tested the moderating effect of intrinsic life goals on the link between magazine consumption and body image dissatisfaction via an online questionnaire (Study 1; N = 826), then experimentally manipulated these goals and exposure to images of muscular male models (Study 2; N = 150). A robust protective effect of intrinsic goals on body image satisfaction was observed - the relationship between magazine consumption and body image dissatisfaction was only significant among individuals with a lower level of intrinsic life goal orientation. When participants' intrinsic goals were momentarily heightened, they reported significantly less body image dissatisfaction, compared to those not receiving a strengthening of these goals. The results are the first to find a protective effect of intrinsic life goals on men's body image, and have important implications for intervention.


Subject(s)
Body Dissatisfaction , Body Image , Goals , Humans , Male , Mass Media , Personal Satisfaction
2.
Perspect Psychiatr Care ; 54(1): 54-63, 2018 Jan.
Article in English | MEDLINE | ID: mdl-27925215

ABSTRACT

PURPOSE: To examine the levels and associations of differentiation of self based on Bowen's theory and adult attachment in a sample with anxiety-related disorders. DESIGN AND METHODS: One hundred fourteen adults with anxiety-related disorders and 117 age- and gender-matched controls were recruited. Levels of differentiation of self, adult attachment, and trait and state anxiety were assessed. FINDINGS: Adults with anxiety-related disorders showed significantly lower global levels of differentiation of self after controlling for socio-demographic characteristics. Adults with anxiety-related disorders also displayed significantly higher levels of anxiety and avoidant attachment. PRACTICE IMPLICATIONS: These constructs may be appropriate targets for intervention research in the study of anxiety-related disorders.


Subject(s)
Anxiety Disorders/physiopathology , Anxiety/physiopathology , Object Attachment , Adult , Anxiety/psychology , Anxiety Disorders/psychology , Beijing , Female , Humans , Male , Middle Aged , Young Adult
3.
BMC Psychiatry ; 16: 142, 2016 May 13.
Article in English | MEDLINE | ID: mdl-27177619

ABSTRACT

BACKGROUND: In China, children with Autism Spectrum Disorder (ASD) can potentially benefit from universal education policies and recent initiatives designed to address the needs of children with developmental disorders. However, adequate schooling is often unavailable for children with ASD, in part because teachers lack the knowledge and skills needed to work with this population. To better understand the current state of knowledge of ASD in China, we surveyed knowledge and attitudes regarding the disorder in preschool teachers. METHODS: A total of 471 preschool teachers in the cities of Guangzhou and Foshan, China completed questionnaires assessing participant demographics, knowledge of typical child development and knowledge of ASD, attitudes towards ASD, practices and self-perceptions of efficacy in the education of children with ASD, and awareness of organizations and intervention approaches devoted to the care of individuals with ASD. The correlation between individual- and school-level variables with current knowledge of typical child development and ASD was examined using univariate and multivariate analyses. RESULTS: The majority (84%) of participants answered correctly more than half of the questionnaire items assessing understanding of typical child development. In contrast, 83% provided inaccurate responses to more than half of the questionnaire items assessing knowledge of ASD. Knowledge of typical child development and knowledge of ASD were both associated with geographic region (teachers in Guangzhou had greater knowledge than those in Foshan, p < 0.0001). Knowledge of ASD was also associated with a higher education level (p < 0.05) and school type (p = 0.023). In general, participants believed fairly strongly in the need for greater service provision for children with ASD, and were receptive towards receiving additional specialized training. Most participants were unaware of ASD-specific organizations and empirically validated intervention approaches. CONCLUSIONS: Knowledge of ASD is lacking in preschool teachers in China, and greater teacher training and instruction is needed. Nonetheless, teachers report a willingness and motivation to gain the skills needed to maximize the educational experiences of children with ASD.


Subject(s)
Autism Spectrum Disorder/psychology , Health Knowledge, Attitudes, Practice , School Teachers/statistics & numerical data , Adult , China , Female , Humans , Male , Middle Aged , Self Concept , Surveys and Questionnaires , Young Adult
4.
Asia Pac Psychiatry ; 8(3): 226-37, 2016 Sep.
Article in English | MEDLINE | ID: mdl-26440145

ABSTRACT

INTRODUCTION: The Schizotypal Personality Questionnaire (SPQ) is a self-report measure assessing symptoms of schizotypy. The SPQ has been used in both normative and clinical samples and has much theoretical and empirical support. A three-factor structure of the SPQ, derived on the basis of work in schizophrenia, consisting of Cognitive-Perceptual, Interpersonal, and Disorganized factors, has been well replicated. The present study aimed to (i) validate this three-factor structure in the Chinese version of the SPQ in a sample of individuals of Chinese ethnicity, and (ii) test for invariance across sex. METHODS: A total of 209 (99 males) undergraduate university students (Mage = 19.5, SD = 1.6) were administered the SPQ. RESULTS: Confirmatory factor analysis indicated a better fit between the data and the three-factor model compared with a one-factor model. Multigroup confirmatory factor analysis also found strong measurement invariance across sex. DISCUSSION: The current results add to a growing body of literature evidencing cross-cultural validity of the SPQ and its invariance across sex. Research and clinical implications of the current results are discussed.


Subject(s)
Personality Inventory/standards , Schizophrenia/diagnosis , Surveys and Questionnaires/standards , Adolescent , Adult , Factor Analysis, Statistical , Female , Humans , Male , Reproducibility of Results , Young Adult
5.
Int J Offender Ther Comp Criminol ; 60(5): 535-54, 2016 Apr.
Article in English | MEDLINE | ID: mdl-25395476

ABSTRACT

The association between culture-specific personality variables and family factors, and juvenile delinquency, was assessed in a sample of 402 adolescents of Chinese ethnicity between 12 and 17 years of age (Mage = 15.13, SD = 1.41; 135 girls), a subgroup of whom were considered at risk for juvenile delinquency owing to addictive behavior tendencies. Culture-specific personality variables were assessed using the Chinese Personality Assessment Inventory-Adolescent version Interpersonal Relatedness factor. The General Function subscale of the Chinese version of the Family Assessment Device was utilized to assess the influence of perceived levels of family functioning. Both culture-specific personality variables and non-culture-specific familial factors were significantly and negatively associated with self-reported juvenile delinquency (p < .001). However, in a sample of at-risk adolescents, only a culture-specific variable measuring orientation toward the family was able to predict self-reported juvenile delinquency (p < .001). Implications of the current results are discussed.


Subject(s)
Culture , Juvenile Delinquency , Personality , Adolescent , Child , China/ethnology , Female , Humans , Juvenile Delinquency/ethnology , Male , Personality Inventory , Self Report
6.
Autism ; 20(6): 673-86, 2016 08.
Article in English | MEDLINE | ID: mdl-26408634

ABSTRACT

Recent research examining the explanations given by the public (i.e. lay beliefs) for autism spectrum disorder often reveals a reasonably accurate understanding of the biogenetic basis of the disorder. However, lay beliefs often manifest aspects of culture, and much of this work has been conducted in western cultures. In this study, 215 undergraduate university students in Macau, a Special Administrative Region of China, completed self-report measures assessing two beliefs concerning autism spectrum disorder etiology: (1) a belief in parental factors and (2) a belief in genetic factors. Potential correlates of lay beliefs were sought in culture-specific values, and more universal social axioms. Participants were significantly more likely to endorse parenting, relative to genetic factors, as etiological. A perceived parental etiology was predicted by values of mind-body holism. Beliefs in a parental etiology were not predicted by values assessing collectivism, conformity to norms, a belief in a family's ability to obtain recognition through a child's achievement, or interpersonal harmony, nor by the social axioms measured (e.g. social cynicism, reward for application, social complexity, fate control, and religiosity). Beliefs in a genetic etiology were not predicted by either culture-specific values or social axioms. Implications of the current results are discussed.


Subject(s)
Attitude to Health , Autism Spectrum Disorder/etiology , Autism Spectrum Disorder/psychology , Culture , Health Knowledge, Attitudes, Practice , Social Values , Adult , Female , Genetic Predisposition to Disease , Humans , Macau , Male , Parenting , Students/psychology , Students/statistics & numerical data , Surveys and Questionnaires , Universities , Young Adult
8.
J Nerv Ment Dis ; 203(9): 718-24, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26252822

ABSTRACT

Facial emotion recognition has been found to be impaired in schizophrenia, although overall results have been inconclusive. A new set of facial emotion stimuli with Chinese faces was developed, using static and dynamic avatars, the identification of which were subsequently validated in 562 healthy control subjects. This test was then used to identify facial emotion recognition accuracy in 44 patients with schizophrenia and 41 healthy controls. Overall, patients identified facial emotions significantly worse than healthy controls (p = 0.018) with a significant main effect for type of emotion (p = 0.016). Patients performed significantly worse in fear (p = 0.029) and sadness (p = 0.037), and marginally worse in anger (p = 0.052). No significant differences were evident in contempt (p = 0.254) or happiness (p = 0.943). Regarding error rates of misattribution, patients overidentified contempt (p = 0.035) and sadness (p = 0.01), but not anger, fear, or happiness. Conclusion, patients of Chinese ethnicity with schizophrenia may have significantly greater difficulties identifying negative, but not positive emotions.


Subject(s)
Emotional Intelligence , Facial Expression , Schizophrenic Psychology , Adult , Case-Control Studies , China , Expressed Emotion , Female , Humans , Male , Psychiatric Status Rating Scales , Psychological Tests , Reproducibility of Results , Schizophrenia/diagnosis
9.
Childs Nerv Syst ; 31(8): 1377-85, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25922052

ABSTRACT

PURPOSE: In individuals with a comorbid autistic spectrum disorder and medically refractory epilepsy, vagus nerve stimulation may offer the potential of seizure control and a positive behavioral side effect profile. We aimed to examine the behavioral side effect profile using longitudinal and quantitative data and review the potential mechanisms behind behavioral changes. METHODS: We present a case report of a 10-year-old boy with autistic spectrum disorder and epilepsy, who underwent vagus nerve stimulation subsequent to unsuccessful treatment with antiepileptic medication. RESULTS: Following vagus nerve stimulation implantation, initial, if temporary, improvement was observed in seizure control. Modest improvements were also observed in behavior and development, improvements which were observed independent of seizure control. CONCLUSIONS: Vagus nerve stimulation in autistic spectrum disorder is associated with modest behavioral improvement, with unidentified etiology, although several candidates for this improvement are evident.


Subject(s)
Autistic Disorder/therapy , Epilepsy/therapy , Vagus Nerve Stimulation/methods , Autistic Disorder/complications , Child , Epilepsy/complications , Follow-Up Studies , Humans , Male , Streptococcal Infections/complications
10.
Asia Pac Psychiatry ; 7(2): 127-34, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25355450

ABSTRACT

INTRODUCTION: Somatic presentations of distress are common cross-culturally, although perhaps more so in Asian cultures. Somatic presentations of distress may be associated with alexithymia, a difficulty in experiencing and expressing emotions. Although the constructs of somatization and alexithymia have been examined in depth both within and across cultures, there is minimal information on culture-specific behaviors utilized to cope with stress in individuals who tend to somaticize distress or are alexithymic. The current report investigates the association between somatization and alexithymia, and a culture-specific behavior of traditional Chinese medicinal herbal tea consumption, in a nonclinical, young adult sample. METHODS: A sample of 222 undergraduate university students of Chinese ethnicity completed self-report measures of somatization and the related construct of somatosensory amplification, alexithymia, and attitude toward the consumption of herbal tea possessing traditional Chinese medicinal value. RESULTS: After controlling for gender, alexithymia was significantly correlated with somatization (r[220] = 0.29, P < 0.05) and somatosensory amplification (r[220] = 0.19, P < 0.05). Attitudes toward herbal tea consumption were significantly correlated with somatosensory amplification (r[220] = 0.16, P < 0.05). DISCUSSION: The connection between alexithymia and somatization was confirmed in the current report in a nonclinical sample. A culture-specific behavior (consumption of traditional Chinese medicinal herbal tea) was significantly associated with somatosensory amplification. Potential etiologies and implications of the current findings are discussed.


Subject(s)
Affective Symptoms/psychology , Attitude to Health , Medicine, Chinese Traditional , Somatoform Disorders/psychology , Teas, Herbal , Adolescent , Adult , Affective Symptoms/complications , Asian People , Female , Humans , Male , Self Report , Somatoform Disorders/complications , Students , Surveys and Questionnaires , Young Adult
11.
Australas Psychiatry ; 22(2): 127-31, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24619959

ABSTRACT

OBJECTIVES: Joiner's Interpersonal Theory of Suicide, which states that an individual will desire death when they perceive themselves to be a burden to others, and experience social isolation, has received much support, but has not been directly assessed in non-Eurocentric individuals. METHODS: Joiner's Interpersonal Needs Questionnaire (measuring both perceived burdensomeness and thwarted belongingness) and measures of depression, hopelessness, gender, relationship status and region of residence were evaluated as risk factors for suicidality after controlling for response biases. Participants were 273 undergraduate university students of Chinese ethnicity between the ages of 17 and 23 years in Macao. RESULTS: The predictors in sum distinguished between the presence and absence of suicidality (χ(2) = 62.759, p < .01). Perceived burdensomeness (p < .01) and relationship status (p < .01) made significant contributions to the presence of suicidality. Low internal consistency prevented thwarted belongingness from being assessed as a risk factor. CONCLUSIONS: Interpersonal variables may account for the seemingly disparate risk factors for suicide.


Subject(s)
Interpersonal Relations , Stress, Psychological/psychology , Students/psychology , Suicidal Ideation , Suicide/psychology , Universities , Adolescent , Depression/psychology , Female , Hope , Humans , Macau , Risk Factors , Sex Factors , Social Isolation , Young Adult
12.
Aust N Z J Psychiatry ; 46(11): 1053-7, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22696549

ABSTRACT

OBJECTIVE: Somatic presentations of distress are common cross-culturally and are thought to predominate in Asian cultures such as that of China. From an etic perspective, researchers utilizing empirically validated standardized assessment measures find that somatic symptoms are no more common in individuals of Chinese descent than they are in individuals of European descent. In contrast, patient presentations are heavily influenced by culture and are associated with patterns of illness behavior. The objective of the current review is to determine the culture-specific factors contributing to somatic presentations and descriptions of distress in China. METHOD: The current review was based on a literature search of PubMed and PsychInfo using the terms 'China,' 'Asia,' 'somatoform,' 'somatization,' and 'psychogenic.' RESULTS: Factors contributing to somatic presentations of distress in China include stigma and help-seeking behavior, and assessment approaches that ignore culture-specific patterns of symptom reporting, fail to incorporate somatic metaphor and Chinese conceptualizations of distress that emphasize bodily sensation, and ignore the role that culture-specific normative data and culture specific response patterns may produce on assessment results. CONCLUSIONS: From an emic perspective, there are numerous factors contributing to the appearance of a predominantly somatic presentation of distress in China. Implications for clinical practice are discussed.


Subject(s)
Asian People/psychology , Somatoform Disorders/ethnology , Stress, Psychological/ethnology , China , Culture , Humans , Patient Acceptance of Health Care/ethnology , Social Stigma , Stress, Psychological/physiopathology
13.
Soc Psychiatry Psychiatr Epidemiol ; 47(3): 395-8, 2012 Mar.
Article in English | MEDLINE | ID: mdl-21293843

ABSTRACT

BACKGROUND: The prevalence of autism spectrum disorders (ASD) is generally somewhat lower in countries outside of North America and Europe. While there are culture-specific patterns of social cognitive processing, the influence of such patterns upon ASD prevalence has yet to be fully explored. METHODS: A comprehensive literature search for original articles reporting ASD prevalence was undertaken. Data across studies were compared with a particular focus on variables of geographic residence and ethnicity. RESULTS: ASD prevalence varies across countries in a manner that appears to suggest that the greatest influence is due to methodological variables. The nature of a potential influence of culture-specific patterns of cognitive processing upon prevalence remains unknown. The available little data concerning the association between ethnicity and prevalence are limited to studies within the United States (US) showing differences in children of Hispanic descent relative to Whites, a finding for which a definitive explanation is lacking. CONCLUSIONS: Available evidence suggests that methodological factors are largely responsible for differences in ASD prevalence across studies. The much discussed increase in prevalence in ASD has been observed worldwide, suggesting that the refinement of diagnostic methodology and/or broadening diagnostic concept is not limited to Western countries. Within individual countries, only in the US has the influence of ethnicity upon ASD prevalence been examined in depth. In the US, children of Hispanic descent have the lowest prevalence of ASD, while Whites tend to have the highest prevalence of ASD. Hypothesized etiological factors for such prevalence differences include methodological factors, socioeconomic variables, and bias.


Subject(s)
Child Development Disorders, Pervasive/ethnology , Child Development Disorders, Pervasive/epidemiology , Child, Preschool , China/epidemiology , Cross-Cultural Comparison , Humans , Oman/epidemiology , Sweden/epidemiology , United Kingdom/epidemiology , United States/epidemiology
14.
J Genet Psychol ; 172(1): 56-66, 2011.
Article in English | MEDLINE | ID: mdl-21452752

ABSTRACT

The authors characterized the cognitive, adaptive, and behavioral sequelae of Coffin-Siris (CS) syndrome and epilepsy in a 7.5-year-old child. Little is known about the early neurobehavioral presentation of CS. Clinical features consistent with this genetic anomaly include underdeveloped tips and nails of the fifth fingers, extended infranasal depression, and craniofacial abnormalities. MRI findings often reveal callosal agenesis. The authors conducted a neuropsychological evaluation and obtained parental ratings of behavioral and adaptive functioning. Attentional abilities were limited. As assessed by the Mullen Scales of Early Learning, receptive language abilities (age equivalent [AE]: 3-3) were relatively stronger than expressive skills (AE: 1-4). Adaptive functioning was low across all domains (Vineland Adaptive Behavior Composite AE: 1-9). On the Behavior Assessment for Children (BASC-2), social skills dysfunction, stereotyped and self-stimulatory behaviors, restricted interests, ritualistic play, and inappropriate object usage were noted. No significant mood disturbances were endorsed. Study findings indicate a diffuse pattern of neurobehavioral deficits in a child with CS and epilepsy. Further clinical assessment and research should include multidimensional assessment techniques, including evaluation of adaptive behavior, in an effort to capture the full range developmental sequelae in children with CS.


Subject(s)
Acrocallosal Syndrome/diagnosis , Child Behavior Disorders/diagnosis , Epilepsies, Partial/diagnosis , Epilepsy, Complex Partial/diagnosis , Epilepsy, Tonic-Clonic/diagnosis , Intellectual Disability/diagnosis , Social Adjustment , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/genetics , Abnormalities, Multiple/psychology , Acrocallosal Syndrome/genetics , Acrocallosal Syndrome/psychology , Child , Child Behavior Disorders/genetics , Child Behavior Disorders/psychology , Child Development Disorders, Pervasive/diagnosis , Child Development Disorders, Pervasive/genetics , Child Development Disorders, Pervasive/psychology , Communication Aids for Disabled , Disability Evaluation , Epilepsies, Partial/genetics , Epilepsies, Partial/psychology , Epilepsy, Complex Partial/genetics , Epilepsy, Complex Partial/psychology , Epilepsy, Tonic-Clonic/genetics , Epilepsy, Tonic-Clonic/psychology , Face/abnormalities , Hand Deformities, Congenital/diagnosis , Hand Deformities, Congenital/genetics , Hand Deformities, Congenital/psychology , Humans , Intellectual Disability/genetics , Intellectual Disability/psychology , Language Development Disorders/diagnosis , Language Development Disorders/genetics , Language Development Disorders/psychology , Micrognathism/diagnosis , Micrognathism/genetics , Micrognathism/psychology , Neck/abnormalities , Neuropsychological Tests , Socialization
15.
Child Neuropsychol ; 16(2): 202-8, 2010.
Article in English | MEDLINE | ID: mdl-19813116

ABSTRACT

This study examines the neuropsychological profile of a boy with congenital central hypoventilation syndrome (CCHS) without a paired-like homeobox gene (PHOX2B) mutation. CCHS is a rare disorder of autonomic nervous system development characterized by an impaired ventilatory response to hypercarbia and hypoxemia. Mild intellectual deficits are common but a specific cognitive profile is not established in CCHS. We describe a nonverbal learning disorder as a CCHS endophenotype and recommend that detailed neuropsychological testing be performed on all individuals with CCHS. Defining the psycho-educational needs in CCHS may avert compounding the emotional and medical stresses of this already debilitating disorder.


Subject(s)
Autonomic Nervous System Diseases/congenital , Hypoventilation/congenital , Hypoventilation/complications , Learning Disabilities/complications , Adolescent , Autonomic Nervous System Diseases/complications , Autonomic Nervous System Diseases/genetics , Child Behavior Disorders/complications , Child Behavior Disorders/genetics , Cognition , Homeodomain Proteins/genetics , Humans , Hypoventilation/genetics , Language , Learning Disabilities/genetics , Male , Mutation , Neuropsychological Tests , Syndrome , Transcription Factors/genetics
16.
Epilepsy Behav ; 13(1): 237-42, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18448391

ABSTRACT

The convergent validity and clinical utility of two parent-report child behavior rating scales, the Behavior Assessment System for Children-Parent Rating Scales (BASC-PRS) and Child Behavior Checklist/Ages 6-18 (CBCL), in children with epilepsy were examined. Analogous broadband and narrowband behavior rating scales were evaluated in 60 subjects aged 6-17 years (mean=11.0, SD=3.4) with Full Scale IQ >70. Correlations for each similarly labeled scale were statistically significant (P<0.002) and greater with broadband (r=0.71-0.79) than with narrowband (r=0.41-0.78) scales. The BASC captured significantly less composite internalizing symptoms (P<0.002), but more unusual thought processes (P<0.0002) and attention problems versus a CBCL DSM-oriented attention-deficit/hyperactivity disorder scale (P<0.002). Variation in the correlations between measures may stem from underlying differences between rationally-and empirically-derived approaches to test construction. Both the CBCL and BASC have diagnostic and clinical utility in assessing behavior problems in pediatric epilepsy.


Subject(s)
Child Behavior Disorders/psychology , Epilepsy/complications , Epilepsy/psychology , Mental Health Services , Parent-Child Relations , Psychological Tests/statistics & numerical data , Adolescent , Child , Child Behavior , Child Behavior Disorders/etiology , Female , Humans , Intelligence Tests , Male , Psychiatric Status Rating Scales , Reproducibility of Results , Statistics, Nonparametric , Surveys and Questionnaires
17.
Pediatr Neurol ; 36(5): 312-7, 2007 May.
Article in English | MEDLINE | ID: mdl-17509463

ABSTRACT

Neuropsychologic test scores from a group of children with epilepsy were compared to the standardization sample of the NEPSY: A Developmental Neuropsychological Assessment, a relatively new neuropsychologic testing instrument. Nineteen children with a confirmed diagnosis of epilepsy (11 boys, 8 girls), aged 3-12 years, participated. Attention/executive function, language, sensorimotor, visuospatial, and learning/memory domain scores were examined, as well as individual subtest scores. The mean scores on the attention/executive function, language, and sensorimotor domains were >1.5 standard deviations below the normative mean, and significantly lower than the mean visuospatial domain score (P < 0.05). The mean language domain score was also significantly lower than the learning/memory score (P < 0.05). Mean subdomain scores varied, with impairment on two tasks measuring rapid automatic processing and graphomotor precision, respectively. On the majority of subtests, 15% or more of the sample scored in the impaired range. Associations between patient age, seizure onset age, seizure frequency, and antiepileptic medication status were not associated with outcome, perhaps due in part to the small sample size. The strengths and weaknesses of the NEPSY as a measure of neuropsychologic functioning in children with epilepsy, and its utility in highlighting risks to academic achievement are discussed.


Subject(s)
Epilepsy/physiopathology , Epilepsy/psychology , Neuropsychological Tests , Age Factors , Anticonvulsants/therapeutic use , Child , Child, Preschool , Epilepsy/drug therapy , Female , Humans , Male , Mental Processes/physiology , Psychomotor Performance/physiology , Reproducibility of Results , Severity of Illness Index
18.
Epilepsia ; 48(8): 1625-8, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17484758

ABSTRACT

Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.


Subject(s)
Tuberous Sclerosis/surgery , Age of Onset , Brain Mapping , Cerebral Cortex/pathology , Cerebral Cortex/physiopathology , Cerebral Cortex/surgery , Child , Child, Preschool , Electroencephalography/statistics & numerical data , Epilepsies, Partial/pathology , Epilepsies, Partial/physiopathology , Epilepsies, Partial/surgery , Epilepsy/pathology , Epilepsy/physiopathology , Epilepsy/surgery , Female , Functional Laterality/physiology , Humans , Magnetic Resonance Imaging/statistics & numerical data , Male , Postoperative Complications , Preoperative Care , Retrospective Studies , Treatment Outcome , Tuberous Sclerosis/pathology , Tuberous Sclerosis/physiopathology
19.
Epilepsia ; 48(3): 539-45, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17284300

ABSTRACT

PURPOSE: Functional mapping of eloquent cortex with electrical neurostimulation is used both intra- and extraoperatively to tailor resections. In pediatric patients, however, functional mapping studies frequently fail to localize language. Wada testing has also been reported to be less sensitive in children. METHODS: Thirty children (4.7 - 14.9 years) and 18 adult controls (18-59 years) who underwent extraoperative language mapping via implanted subdural electrodes at the NYU Comprehensive Epilepsy Center were included in the study. Ten children and 14 adults underwent preoperative Wada testing. Success of the procedures was defined as the identification of at least one language site by neurostimulation mapping and determination of hemispheric language dominance on the Wada test. RESULTS: In children younger than 10.2 years, cortical stimulation identified language cortex at a lower rate than was seen in children older than 10.2 years and in adults (p<0.05). This threshold, demonstrated by survival and chi2 analysis, was sharply defined in our data set. Additionally, Wada testing was more likely to be successful than was extraoperative mapping in this younger age group (p<0.05). CONCLUSIONS: Analysis of our series demonstrates that language cortex is less likely to be identified in children younger than 10 years, suggesting that alternatives to the current methods of cortical electrical stimulation, particularly the use of preoperative language lateralization, may be required in this age group.


Subject(s)
Amobarbital , Cerebral Cortex/physiopathology , Cerebral Cortex/surgery , Epilepsy/physiopathology , Functional Laterality/physiology , Language , Adolescent , Adult , Age Factors , Amobarbital/pharmacology , Brain Mapping/methods , Carotid Artery, Internal , Cerebral Cortex/drug effects , Child , Child, Preschool , Electric Stimulation , Epilepsy/surgery , Female , Humans , Injections, Intra-Arterial , Intraoperative Care , Male , Middle Aged , Preoperative Care
20.
Seizure ; 15(7): 558-62, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16935530

ABSTRACT

In patients with tuberous sclerosis complex (TSC), the high rates of mental retardation are associated with cortical tubers, seizure activity, and genetic factors. The goal of the study was to investigate the relationship between bilateral cortical tubers and seizure variables and mental retardation in individuals with TSC. The records of 27 patients with TSC (age 6 months to 33 years) undergoing neuropsychological assessment and the following clinical variables were examined: bilateral versus non-bilateral cortical tubers, the age of seizure onset, and presence of infantile spasms. Results were statistically analyzed. Bilateral cortical tubers (p=0.02) and early age of seizure onset (p=0.04) were significantly related to impaired cognitive functioning. Only one of the seven patients with normal cognitive functioning had bilateral tubers, whereas 13/21 patients with intellectual impairment had bilateral tubers. Patients with normal cognitive functioning experienced a mean age of seizure onset after 6 years. A trend was observed between infantile spasms and cognitive functioning (p=0.06); the lack of statistical significance likely reflects the small sample size. Neither age nor gender was related to cognitive status. Further investigation incorporating additional neuroimaging factors, antiepileptic treatment effects, and genetic variables, is needed.


Subject(s)
Cognition Disorders/etiology , Epilepsy/etiology , Intellectual Disability/etiology , Tuberous Sclerosis/complications , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Intelligence , Male , Neuropsychological Tests , Retrospective Studies , Spasms, Infantile/etiology , Tuberous Sclerosis/pathology
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