Digital Tools in UMLS Metathesaurus Knowledge Processing.

Clinical search engines development is actual task for medical informatics. The main issue in this area is to implement high-quality unstructured texts processing. Ontological interdisciplinary metathesaurus UMLS can be used to solve this problem. Currently, there is no unified method to relevant information aggregation from UMLS. In this research, we have presented the UMLS as graph model and performed the spot check of UMLS structure to identify basic problems. Then we created and integrated new graph metric in two created by us program modules for relevant knowledge aggregation from UMLS.

Assimilation Results Comparison of Educational Material by Senior Students of a Medical University in Distance and Face-to-Face Form Education.

Despite the fact that many researchers and teachers reported that distance education can be equated with traditional face-to-face form education, the question of analyzing the quality of knowledge gained in distance education is open. This study was conducted on the basis of the Department of Medical Cybernetics and Informatics named after S.A. Gasparyan of Russian National Research Medical University. N.I. Pirogov for the period from September 1, 2021 to March 14, 2023 and included results of answers of two variance of test on the same topic. The responses of students who missed the lectures were not included in the processing. For 556 students with distance education, the lesson was held remotely using https://meet.google.com and for 846 students the lesson was performed in face-to-face form education. Students' answers to test tasks were collected using the Google form https://docs.google.com/forms/…The data base statistical assessment and statistical description were made in Microsoft Excel 2010 and IBM SPSS Statistics programs version 23. In this study, it was shown that the results of the learned material assessment for distance education and traditional face-to-face form education are statistically significantly different (p<0.001). The topic studied in face-to-face format was assimilated by 0.85 points better (the difference was five percent of the correct answers received).

Assessment of the Prognostic Accuracy of Scores in Different Ways on the Example of Assessing the Validity of the Prognostic Model ISS-RTS-TRISS.

The aim of the present study was a comparison of prognostic accuracy assessment results for scores in different ways on the example of validity analysis of the prognostic model ISS-RTS-TRISS for assessing the severity of the condition in children with trauma. The prospective study was conducted using clinical and physiological data collected at the admission and during the first 24 hours of hospitalization from 414 children with trauma. We had three groups of patients, common group children with traumatic brain injuries, and two groups of patients were divided into the two following ways: 141 (34%) patients with isolated traumatic brain injuries and 273 (66%) patients with combined injuries with traumatic brain injuries The validity and prognostic accuracy of prognostic scores were assessed by determining there discrimination and calibration ability. Analysis of the discrimination ability of score was carried out by assessment the areas under the ROC curves. For analysis of the calibration ability of score was used three methods of the Hosmer-Lemeshow test (H-criterion, C-criterion in two variants). The ISS-RTS-TRISS score showed significantly outstanding predictive accuracy in studied groups (AUROC >=0.9) .However, estimation the calibration ability of score using the C-criterion, by dividing into groups with the same number of cases of patients (recommended for abnormal distribution) did not show an unambiguous results. It was shown that to obtain an unambiguous correct result, it was necessary to use the C-criterion method using the division of cases into groups with the same number of patients with the lethal outcome. When using this method, satisfactory results of study of calibration ability were shown for all the studied groups (p<0.05).

Estimation of the Accuracy of Prognostic Scores for the Treatment of Children with Severe Trauma in a Specialized Trauma Hospital.

The aim of the present work was to study the validity and prognostic accuracy of scores for assessing the severity of the condition in children with severe trauma, located in the Department of Anesthesiology and Resuscitation in the Clinical and Research Institute of Urgent Pediatric Surgery and Trauma. The prospective study was conducted using clinical and physiological data collected at the admission and during the first 24 hours of hospitalization from 474 patients. The validity and prognostic accuracy of prognostic scores were assessed by determining their discrimination and calibration ability. A comparison of the discriminatory ability of scores was carried out by comparing the areas under the ROC curves with the z-criterion. Four prognostic scores were included into the study: PRISM, APACHE II, ISS-RTS-TRISS, which were used for calculating the severity of injury and for prognosis of death. Score PTS was used for evaluating the severity index only. Our results indicate that only score ISS-RTS-TRISS may be useful in practice (has excellent discrimination ability and significant calibration ability). The other lack either discrimination ability (PRISM) or calibration ability (PTS, APACHE II). The result of the study has shown that only one of the four prognostic scores, ISS-RTS-TRISS, can be successfully used in everyday practice in the department of anesthesiology and resuscitation in the specialized hospital of children's traumatology to assess the severity of the condition, with the possibility of predicting the likelihood of a lethal outcome.

Experience of development of the national surgical interventions coding system in Russia.

The paper discusses development issues of surgical procedures coding systems for use at the national and international levels within the health information systems. The work was carried out using the Russian and foreign experiences, including international standard ISO/FDIS 1828:2012. The development system structure contains basic categories of medical entities (axes): surgical deed and surgical subdeed, objects, site and interventional equipment. Abdominal surgeries (528 procedures) were entered in the coding system database and structured according defined categories.

Nature of DNA-bound fatty acids in Pseudomonas aurantiaca.

The existence of Pseudomonas aurantiaca DNA-bound fatty acids and lipids is presented in this work. The isolation of DNA was carried out by two different procedures, namely, phenol and detergent-based phenol isolation in order to prove the presence of DNA-bound lipids. The lipid content of DNA is expressed in terms of fatty acid profile. A high level of 16:0, 18:0 and 18:1 is characteristic for tightly bound DNA lipids. On the other hand, the fatty acids such as 14:1, iso14:0 and iso16:0 are found in trace amounts only in DNA lipid fraction, but these fatty acids are not found in the whole-cell lipids. Absolutely no 3-hydroxy fatty acids were found in DNA lipids. However, both C16 and C18 species represent the main fatty acids of whole-cell and DNA-bound lipids. The presence of DNA-bound lipids even under tough treatment of DNA allows to conclude that these lipids represent a special pool among cellular lipids.