1.
J Med Chem
; 26(2): 214-7, 1983 Feb.
Article
in English
| MEDLINE
| ID: mdl-6827538
ABSTRACT
A number of azacannabinoids containing hydroxyacyl and aminoacetyl substituents on the nitrogen atom were synthesized. The hydroxyacetyl and gamma-hydroxybutyryl derivatives were potent antihypertensive agents (minimum effective dose, 3-5 mg/kg, orally) of the same order of activity as the highly CNS-active N-propargyl derivatives Ia and Ib. Furthermore, 4a showed weak stimulant properties at hypotensive dose levels, in contrast to the strongly CNS-depressant action characteristic of the N-propargyl analogues.
Subject(s)
Antihypertensive Agents , Cannabinoids/chemical synthesis , Animals , Blood Pressure/drug effects , Cannabinoids/pharmacology , Heart Rate/drug effects , Hypertension/physiopathology , Indicators and Reagents , Magnetic Resonance Spectroscopy , Rats , Structure-Activity Relationship
2.
J Med Chem
; 26(2): 278-80, 1983 Feb.
Article
in English
| MEDLINE
| ID: mdl-6681843
Subject(s)
Cannabinoids/chemical synthesis , Central Nervous System/drug effects , Aggression/drug effects , Animals , Aza Compounds/chemical synthesis , Aza Compounds/pharmacology , Behavior, Animal/drug effects , Cannabinoids/pharmacology , Drug Antagonism , Humans , Indicators and Reagents , Magnetic Resonance Spectroscopy , Methamphetamine/pharmacology , Mice , Motor Activity/drug effects , Rats , Serotonin/pharmacology , Structure-Activity Relationship
3.
J Med Chem
; 20(11): 1508-11, 1977 Nov.
Article
in English
| MEDLINE
| ID: mdl-915915
Subject(s)
Behavior, Animal/drug effects , Cannabinoids/chemical synthesis , Pyridines/chemical synthesis , Analgesics/chemical synthesis , Animals , Antidepressive Agents/chemical synthesis , Benzopyrans/chemical synthesis , Benzopyrans/pharmacology , Cannabinoids/pharmacology , Dogs , Hypnotics and Sedatives/chemical synthesis , Mice , Motor Activity/drug effects , Pyridines/pharmacology , Rats , Tranquilizing Agents/chemical synthesis
4.
Life Sci
; 17(1): 97-103, 1975 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-1143015
Subject(s)
Anticonvulsants , Benzopyrans/pharmacology , Animals , Behavior, Animal/drug effects , Electroshock , Male , Mice , Phenytoin/pharmacology , Rats , Structure-Activity Relationship
5.
Biochemistry
; 11(3): 385-7, 1972 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-5059119