ABSTRACT
Radiotherapy is one of the main methods of malignant tumor treatment. The radiotherapy department in Burdenko Main Military-and-clinical Hospital as a part of a radiological center has been working for 40 years. During vhis period it has constantly been developing its technical base, quality of irradiation and professionalism of its staff. And nowadays at the modern stage there exists a real perspective of future development of radiological treatment for servicemen and their families' members basing on the radiotherapy department in Burdenko MMCH.
Subject(s)
Hospitals, Military/organization & administration , Radiology Department, Hospital/organization & administration , History, 20th Century , History, 21st Century , Hospitals, Military/history , Quality of Health Care , Radiation Oncology/history , Radiation Oncology/standards , Radiology Department, Hospital/history , Radiotherapy, High-Energy/history , Radiotherapy, High-Energy/instrumentation , Radiotherapy, High-Energy/standards , Russia , WorkforceABSTRACT
The efficacy of parallel and successive chemoradial treatment of patients with nasopharynx carcinoma was investigated in the radiological center of Burdenko MMCH. The main group consisted of 42 patients, the control group included 44 patients. They were from 21 to 78 years old. 71% of the patients had the 3rd and the 4th stages of the tumor process; 29% had the 1st and the 2nd stages; 68,6% had the metastatic nodal involvement of regional zones. The radial therapy of the locoregional zone was administered by means of the splitting course using the classic method of fractionating a dose up to the total optimal dose of 64-70 Gr. Polychemotherapy consisted of 6 courses cisplatin, farmarubicin, and platinum. Due to the treatment the 5-year survival rate increased from 41,2% to 78,5% (P < 0,001). With the metastatic nodal involvement of regional zones that rate reduced from 83,3% to 72,8% (P > 0,05) in the main group and from 63,8% to 31,9% (P < 0,001) in the control group.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Nasopharyngeal Neoplasms/drug therapy , Nasopharyngeal Neoplasms/radiotherapy , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Cisplatin/administration & dosage , Cisplatin/adverse effects , Combined Modality Therapy , Disease-Free Survival , Epirubicin/administration & dosage , Epirubicin/adverse effects , Female , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Humans , Male , Middle Aged , Nasopharyngeal Neoplasms/pathology , Neoplasm Metastasis , Neoplasm Staging , Radiation DosageABSTRACT
The article gathers the experience of therapy for lymphogranulomatosis of 1122 patients during last 12 years, and gives the summary of its immediate results. The only radiation therapy was employed for 11.3% of patients, chemical therapy--for 1.2%, and combined therapy in which both radiation and chemical therapy were used--87%. The simultaneous employment of radiation and chemical therapy led to a considerable reduction of the period of treatment, moreover there were no pronounced depressions in medullary hemoplasty. The further progression of the disease was commonly marked only in the cases with general manifestation of illness and affection of more than two globate glands. It is recommended to continue polychemical treatment for a year after the patient's recovery in order to prevent relapses.
