ABSTRACT
Results of application of the preparations made of mycobacteria, clostridia, staphylococci and streptococci, lactobacteria, Salmonella, Streptomyces and other are analyzed. Researchers in different countries pay great attention to the antitumour activity of capsular and somatic antigens of a microbic cell, its separate anatomical structures, enzymes, lipids, polypeptides and especially polysaccharides. The action of bacterial preparations and factors restraining their application in clinical oncology are considered.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Biological Products/therapeutic use , Neoplasms, Experimental/therapy , Neoplasms/therapy , Animals , Clostridium , Humans , Immunity, Innate/drug effects , Lactobacillus , Mycobacterium , Neoplasms/immunology , Neoplasms, Experimental/immunology , Salmonella , Spores, Bacterial , Staphylococcus , Streptococcus , Streptomyces , YeastsSubject(s)
Gram-Negative Aerobic Bacteria/immunology , Neoplasms/therapy , Animals , Escherichia coli/immunology , Eukaryota/immunology , Humans , Immunity , Listeria monocytogenes/immunology , Mice , Neoplasm Metastasis , Neoplasm Recurrence, Local/prevention & control , Neoplasms/immunology , Neoplasms, Experimental/immunology , Neoplasms, Experimental/therapy , Postoperative Care , Proteus vulgaris/immunology , Pseudomonas aeruginosa/immunologyABSTRACT
The results of clinical and experimental studies with corynebacteria stimulation of antitumour resistance are described. It is shown that antitumour effect depends on the mode, dose and period of corynebacteria administration as well as on the stage of the tumour process. The mode of corynebacteria action is under discussion. There are doubts as to expediency of such a method of nonspecific immunotherapy of malignant tumours.