ABSTRACT
Lymphocytes phospholipid membranes fatty acid spectrum was studied in patients with coronary heart disease. The study involved 77 patients aged 45 to 72 years. Significant decrease of the oleic fatty acid relative content was determined, which violates the lymphocytes membranes structure and possibly negatively affect their functioning. The relative content of arachidonic, palmitic and stearic saturated fatty acids composition of lymphocytes lipids increased. The result indicate that in patients with coronary heart disease increasing polyunsaturated fatty acids elongation in lymphocytes. These changes in the lipid blood, lymphocytes state can explain the observed increase in lymphocytes functional activity.
Subject(s)
Cell Membrane/metabolism , Fatty Acids/chemistry , Lymphocytes/metabolism , Myocardial Ischemia/metabolism , Phospholipids/chemistry , Aged , Case-Control Studies , Fatty Acids/metabolism , Humans , Middle Aged , Myocardial Ischemia/blood , Phospholipids/metabolismABSTRACT
Postprandial hypotension is the independent risk factor of general mortality, coronary disorders and stroke. It is reviewed risk factors, pathogenesis, symptoms, treatment and prognosis of this disease.
Subject(s)
Hypotension/etiology , Postprandial Period , Blood Pressure/drug effects , Diet , Hemodynamics/drug effects , Humans , Hypotension/diagnosis , Hypotension/therapy , Prognosis , Risk Factors , Vasoconstrictor Agents/administration & dosage , Vasoconstrictor Agents/therapeutic useABSTRACT
The research of more effective unstable angina treatment is still actual despite the definite protocols exist. It was investigated the lipid acids spectrum of platelet membrane phospholipids in patients with new-onset angina and was analyzed the impact of clopidogrel and aspigrel on its changes.
Subject(s)
Angina, Unstable/drug therapy , Aspirin/therapeutic use , Blood Platelets/drug effects , Cell Membrane/drug effects , Fatty Acids/metabolism , Phospholipids/metabolism , Platelet Aggregation Inhibitors/therapeutic use , Ticlopidine/analogs & derivatives , Aged , Angina, Unstable/blood , Angina, Unstable/diagnosis , Aspirin/administration & dosage , Blood Platelets/metabolism , Cell Membrane/metabolism , Clopidogrel , Drug Combinations , Female , Humans , Male , Middle Aged , Platelet Aggregation Inhibitors/administration & dosage , Ticlopidine/administration & dosage , Ticlopidine/therapeutic use , Treatment OutcomeABSTRACT
The coronary thrombosis is the main factor which leads to acute coronary syndrome. The mechanisms of the coronary thrombogenesis are not found out in detail. It was investigated the changes of the lipid acids spectrum of platelet membrane phospholipids in patients with unstable angina.
Subject(s)
Acute Coronary Syndrome/blood , Angina, Unstable/blood , Blood Platelets/chemistry , Fatty Acids/analysis , Phospholipids/analysis , Acute Coronary Syndrome/pathology , Aged , Angina, Unstable/pathology , Cell Membrane/chemistry , Chromatography, Gas , Disease Progression , Female , Humans , Male , Middle Aged , Severity of Illness IndexABSTRACT
The modern cardiology pays much attention to research of myocardial ischemia, especially painless myocardial ischemia as the problem of sudden coronary death. Findings from the current study suggest that antianginal therapy which includes antiaggregant and anticoagulant is effective because of decreasing general myocardial ischemia and its painless form.
Subject(s)
Angina, Unstable/drug therapy , Aspirin/therapeutic use , Myocardial Ischemia/drug therapy , Platelet Aggregation Inhibitors/therapeutic use , Ticlopidine/analogs & derivatives , Aged , Angina, Unstable/complications , Aspirin/administration & dosage , Clopidogrel , Drug Combinations , Drug Therapy, Combination , Humans , Middle Aged , Myocardial Ischemia/complications , Platelet Aggregation Inhibitors/administration & dosage , Ticlopidine/administration & dosage , Ticlopidine/therapeutic use , Treatment OutcomeABSTRACT
Branched-chain amino acids play the key role in many metabolism processes in organism generally and in cardiovascular protection. It was discovered its importance in mitochondrial biogenesis, antioxidant and antiaging processes, its antihypertension and antiarrhythmic effects, its role in obesity and diabetes mellitus.
Subject(s)
Amino Acids, Branched-Chain/metabolism , Cardiovascular Diseases/etiology , Animals , Cardiovascular Diseases/metabolism , Humans , Insulin Resistance , Mitochondria, Heart/metabolism , Obesity/complications , Obesity/metabolism , Risk FactorsABSTRACT
The coronary circulation dysfunction in patients with unstable angina pectoris causes development of ventricular and supraventricular cardiac rhythm disorders. Findings from the current study suggest that antianginal therapy of patients with acute coronary syndrome which includes antiaggregant and anticoagulant is effective in the treatment of extrasystolic arrhythmias.
Subject(s)
Angina, Unstable/drug therapy , Aspirin/therapeutic use , Heart Rate/drug effects , Ticlopidine/analogs & derivatives , Ventricular Premature Complexes/drug therapy , Aged , Angina, Unstable/complications , Angina, Unstable/physiopathology , Aspirin/administration & dosage , Clopidogrel , Drug Combinations , Electrocardiography, Ambulatory , Humans , Middle Aged , Ticlopidine/administration & dosage , Ticlopidine/therapeutic use , Treatment Outcome , Ventricular Premature Complexes/etiology , Ventricular Premature Complexes/physiopathologyABSTRACT
Silent myocardial ischemia (SMI) is a poor prognostic sign of cardiac events development, such as myocardial infarction and sudden cardiac death. This article presents the last decade research findings dedicated exploring mechanisms of SMI development and prognostic value in patients with coronary heart disease.
Subject(s)
Death, Sudden, Cardiac/pathology , Ganglia, Sympathetic/pathology , Myocardial Infarction/pathology , Myocardial Ischemia/pathology , Asymptomatic Diseases , Death, Sudden, Cardiac/etiology , Disease Progression , Electrocardiography , Female , Ganglia, Sympathetic/metabolism , Humans , Male , Myocardial Infarction/diagnosis , Myocardial Infarction/etiology , Myocardial Infarction/metabolism , Myocardial Ischemia/complications , Myocardial Ischemia/diagnosis , Myocardial Ischemia/metabolism , Nociception/physiology , Opioid Peptides/metabolism , Receptors, Purinergic P1/metabolism , Risk FactorsABSTRACT
These literatures are analyses about reasons, pathogenesis, and clinical displays obstructive sleep apnea. Mechanisms over of connection are brought sleep obstructive apnea with development of hypertensive, of cardiac arrhythmias, development of metabolic syndrome, obesity, to pulmonary hypertension, write ventricular insufficiency.
Subject(s)
Arrhythmias, Cardiac/physiopathology , Hypertension, Pulmonary/physiopathology , Hypertension/physiopathology , Metabolic Syndrome/physiopathology , Obesity/physiopathology , Sleep Apnea, Obstructive/physiopathology , Age Factors , Arrhythmias, Cardiac/complications , Arrhythmias, Cardiac/diagnosis , Humans , Hypertension/complications , Hypertension/diagnosis , Hypertension, Pulmonary/complications , Hypertension, Pulmonary/diagnosis , Metabolic Syndrome/complications , Metabolic Syndrome/diagnosis , Obesity/complications , Obesity/diagnosis , Risk Factors , Severity of Illness Index , Sex Factors , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/diagnosisABSTRACT
Determined the decrease in dopamine activity with age, that contributes to the pathogenesis of hypertension, abdominal obesity, the development of left ventricular hypertrophy. The article presents information describing the age-sensitive regulation of the cardiovascular system in elderly people, confirming the influence of the activity of dopamine receptors in the development of age pathology.
Subject(s)
Aging/metabolism , Cardiovascular System/metabolism , Dopamine/metabolism , Hypertension/metabolism , Hypertrophy, Left Ventricular/metabolism , Obesity, Abdominal/metabolism , Receptors, Dopamine/metabolism , Aged , Aging/pathology , Blood Pressure , Body Mass Index , Cardiac Volume , Cardiovascular System/pathology , Cardiovascular System/physiopathology , Heart Rate , Humans , Hypertension/pathology , Hypertension/physiopathology , Hypertrophy, Left Ventricular/pathology , Hypertrophy, Left Ventricular/physiopathology , Middle Aged , Obesity, Abdominal/pathology , Obesity, Abdominal/physiopathology , Signal TransductionABSTRACT
Hypoxia accompanied chronic obstructive pulmonary disease leads to hypercoagulation, vessels' inflammation, imbalance of oxidative and antioxidative systems. These pathological changes cause arterial hypertension, corpulmonale, metabolism disturbance of the whole organism.
Subject(s)
Cardiovascular Diseases/etiology , Hypertension, Pulmonary/complications , Hypoxia/complications , Inflammation/complications , Pulmonary Disease, Chronic Obstructive/complications , Adipose Tissue/metabolism , Adipose Tissue/pathology , Blood Vessels/metabolism , Blood Vessels/pathology , Cardiovascular Diseases/metabolism , Cardiovascular Diseases/pathology , Disease Progression , Endothelium, Vascular/metabolism , Endothelium, Vascular/pathology , Humans , Hypertension, Pulmonary/metabolism , Hypertension, Pulmonary/pathology , Hypoxia/metabolism , Hypoxia/pathology , Inflammation/metabolism , Inflammation/pathology , Oxidation-Reduction , Pulmonary Disease, Chronic Obstructive/metabolism , Pulmonary Disease, Chronic Obstructive/pathologyABSTRACT
Violations gumoralis and cellular immunity examine as one of anchormen of pathogenetic mechanisms development of ischemic heart trouble. These literatures over, that testifying to development of disbalance of subpopulations of T- and B-lymphocitis, are brought, and also levels of immunoglobulin for patients with the stable and unstable flow of ischemic heart trouble.
Subject(s)
Acute Coronary Syndrome/immunology , Atherosclerosis/immunology , Chlamydophila Infections/immunology , Immunity, Cellular , Immunity, Humoral , Acute Coronary Syndrome/complications , Acute Coronary Syndrome/pathology , Atherosclerosis/complications , Atherosclerosis/pathology , B-Lymphocyte Subsets/immunology , B-Lymphocyte Subsets/pathology , Chlamydophila Infections/complications , Chlamydophila Infections/pathology , Chlamydophila pneumoniae/immunology , Cytokines/immunology , Endotoxins/immunology , Humans , Severity of Illness Index , T-Lymphocyte Subsets/immunology , T-Lymphocyte Subsets/pathologyABSTRACT
We performed an analysis of scientific studies about arterial stiffness impacting on cardiovascular diseases and special mechanisms of its developing. One of these mechanisms is hypoxie endothelial damage. Pulse pressure, aortic pulse wave velocity, the shape of the blood pressure curve, rheography, rheovasography are the methods for determinating arterial stiffness.
Subject(s)
Aorta/physiopathology , Cardiovascular Diseases/physiopathology , Hypoxia/physiopathology , Vascular Stiffness , Aorta/pathology , Blood Flow Velocity , Blood Pressure , Cardiovascular Diseases/complications , Cardiovascular Diseases/pathology , Elasticity , Humans , Hypoxia/complications , Hypoxia/pathology , Plethysmography, Impedance , Pulsatile Flow , Risk Factors , Vascular ResistanceABSTRACT
Article is devoted to the study of immunoglobulins (Ig) classes A, G and M in blood serum of patients with stable and unstable clinical course of ischemic heart disease that improve our knowledge about immuneinflammatory process which develops under destabilization of a coronary circulation.
Subject(s)
Angina Pectoris/immunology , Angina, Unstable/immunology , Immunoglobulin A/blood , Immunoglobulin G/blood , Immunoglobulin M/blood , Angina Pectoris/blood , Angina Pectoris/physiopathology , Angina, Unstable/blood , Angina, Unstable/physiopathology , Case-Control Studies , Coronary Circulation , HumansABSTRACT
The article is devoted to the study of metabolism of polynonsaturated fat acids in a human body as antiatherogenous which prevents the development of cardiovascular diseases (ischemic heart disease, hypertension), as well as oncological diseases, a peptic ulcer of the stomach and duodenum.
Subject(s)
Cardiovascular Diseases/metabolism , Fatty Acids, Unsaturated/metabolism , Neoplasms/metabolism , Peptic Ulcer/metabolism , Cardiovascular Diseases/etiology , Humans , Lipid Metabolism , Neoplasms/etiology , Peptic Ulcer/etiologyABSTRACT
Ischemic heart desease (IHD) remains actual issue of the current clinical medicine, because, IHD takes a leading position among reasons of death rate of population. Purpose of the study was to find diagnostic features of fat-acid composition of lipid of thrombocytes in patients with stable and unstable course of ischemic heart disease (IHD). 52 patients with an unstable angina pectoris aged 42-65 years and 31 patients with stable angina aged 41-66 years have been observed. Reliable changes in relation of the sum of saturated, unsaturated and poli-unsaturated of fat acids of phosphotides of thrombocytes in patients with unstable course of ischemic heart disease (IHD) have been detected. It improves knowledge about the mechanisms of destabilization of coronal circulation of blood.
Subject(s)
Angina Pectoris/blood , Blood Platelets/metabolism , Fatty Acids/metabolism , Adult , Aged , Angina Pectoris/metabolism , Angina, Unstable/blood , Angina, Unstable/metabolism , Case-Control Studies , Humans , Middle Aged , Phospholipids/metabolismABSTRACT
Cardio-vascular diseases and acute coronary syndrome (ACS) in the first place play the first role in the structure of diseases and mortality of world population. Effective method of diagnostics of ACS consists in detecting early and late biomarkers of myocardium necrosis. The article presents characteristics of such biomarkers indices as myoglobin, cardiotroponins, MB-fractions of creatine phosphokinase, cardio-form of protein, lactate dehydrogenase, aspartate aminotransferase. The authors described in the artcile diseases which are accomponied with increase in the level of cardiotroponins.
Subject(s)
Acute Coronary Syndrome , Biomarkers/analysis , Myocardium , Acute Coronary Syndrome/diagnosis , Acute Coronary Syndrome/metabolism , Acute Coronary Syndrome/pathology , Humans , Myocardium/enzymology , Myocardium/metabolism , Myocardium/pathology , Necrosis , Time FactorsABSTRACT
We have studied the influence of Etmosin medication on severity of IHD clinical presentations and comprised biliary motility in 162 patients aged 26 to 60. Dynamic echocholecystography (DECG) has been applied. The obtained data suggest using Etmosin in patients with ischemic heart disease and comprised biliary motility makes for normalizing tonus of the Odi sphincter and decreasing the rate of episodes of angina pectoris, although was not found any influence of Etmosin on gall-bladder motility. The use of Etmosin enables in patients with IHD and comprised biliary motility to decrease reflex angina pectoris.
Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Biliary Dyskinesia/drug therapy , Moricizine/therapeutic use , Myocardial Ischemia/drug therapy , Parasympatholytics/therapeutic use , Adult , Anti-Arrhythmia Agents/administration & dosage , Biliary Dyskinesia/complications , Biliary Dyskinesia/diagnostic imaging , Humans , Middle Aged , Moricizine/administration & dosage , Myocardial Ischemia/complications , Parasympatholytics/administration & dosage , Sphincter of Oddi Dysfunction/complications , Sphincter of Oddi Dysfunction/diagnostic imaging , Sphincter of Oddi Dysfunction/drug therapy , Treatment Outcome , UltrasonographyABSTRACT
Heart syndrome features associated with pain, the structure of myocardial ischemia and heart rate derangement were studied in patients with ischemic heart disease (IHD) and concomitant biliary dyskinesia (BD). It was established that BD considerably aggravates clinical course of IHD: increase in frequency of pain and painless episodes of myocardial ischemia in patients with stable exertional angina I-II functional classes by NYHA and single supraventricular and ventricular extrasystoles.
Subject(s)
Biliary Dyskinesia/complications , Myocardial Ischemia/complications , Adult , Angina Pectoris/complications , Angina Pectoris/physiopathology , Biliary Dyskinesia/physiopathology , Cardiac Complexes, Premature/complications , Cardiac Complexes, Premature/physiopathology , Disease Progression , Female , Heart Rate , Humans , Male , Middle Aged , Myocardial Ischemia/physiopathologyABSTRACT
Corinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. 56 patients aged 26 to 30 had been prescribed Corinfar-Retard in 20 mg per day for 7 days. Dynamic echocholecystography has applied. Decrease in contraction of gall bladder and normalization of tonic contraction of sphincter Ody was found in the patients with previously diagnosed hypertonic-hyperkinetic type of biliary dyskinesia after having been treated with Corinfar-Retard.
