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1.
Am J Transplant ; 15(4): 914-22, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25648884

ABSTRACT

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation.


Subject(s)
Health Services Accessibility , Kidney Transplantation , Living Donors , Patient Education as Topic , Practice Guidelines as Topic , Humans
2.
Am J Transplant ; 13(4): 851-860, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23398969

ABSTRACT

While kidney paired donation (KPD) enables the utilization of living donor kidneys from healthy and willing donors incompatible with their intended recipients, the strategy poses complex challenges that have limited its adoption in United States and Canada. A consensus conference was convened March 29-30, 2012 to address the dynamic challenges and complexities of KPD that inhibit optimal implementation. Stakeholders considered donor evaluation and care, histocompatibility testing, allocation algorithms, financing, geographic challenges and implementation strategies with the goal to safely maximize KPD at every transplant center. Best practices, knowledge gaps and research goals were identified and summarized in this document.


Subject(s)
Donor Selection/methods , Kidney Transplantation/methods , Living Donors , Renal Insufficiency/therapy , Algorithms , Canada , Histocompatibility Testing , Humans , United States
3.
Am J Transplant ; 13(2): 450-7, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23205926

ABSTRACT

Most centers utilize phone or written surveys to screen candidates who self-refer to be living kidney donors. To increase efficiency and reduce resource utilization, we developed a web-based application to screen kidney donor candidates. The aim of this study was to evaluate the use of this web-based application. Method and time of referral were tabulated and descriptive statistics summarized demographic characteristics. Time series analyses evaluated use over time. Between January 1, 2011 and March 31, 2012, 1200 candidates self-referred to be living kidney donors at our center. Eight hundred one candidates (67%) completed the web-based survey and 399 (33%) completed a phone survey. Thirty-nine percent of donors accessed the application on nights and weekends. Postimplementation of the web-based application, there was a statistically significant increase (p < 0.001) in the number of self-referrals via the web-based application as opposed to telephone contact. Also, there was a significant increase (p = 0.025) in the total number of self-referrals post-implementation from 61 to 116 per month. An interactive web-based application is an effective strategy for the initial screening of donor candidates. The web-based application increased the ability to interface with donors, process them efficiently and ultimately increased donor self-referral at our center.


Subject(s)
Internet , Kidney Transplantation/methods , Tissue and Organ Procurement/methods , Adult , Body Mass Index , Cohort Studies , Female , Humans , Living Donors , Male , Middle Aged , Models, Statistical , Patient Education as Topic , Program Development , Referral and Consultation , Renal Insufficiency/therapy , Retrospective Studies , Software
4.
Am J Transplant ; 12(6): 1392-7, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22487555

ABSTRACT

We propose a Medicare Demonstration Project to develop a standard acquisition charge for kidney paired donation. A new payment strategy is required because Medicare and commercial insurance companies may not directly pay living donor costs intended to lead to transplantation of a beneficiary of a different insurance provider. Until the 1970s, when organ procurement organizations were empowered to serve as financial intermediaries to pay the upfront recovery expenses for deceased donor kidneys before knowing the identity of the recipient, there existed similar limitations in the recovery and placement of deceased donor organs. Analogous to the recovery of deceased donor kidneys, kidney paired donation requires the evaluation of living donors before identifying their recipient. Tissue typing, crossmatching and transportation of living donors or their kidneys represent additional financial barriers. Finally, the administrative expenses of the organizations that identify and coordinate kidney paired donation transplantation require reimbursement akin to that necessary for organ procurement organizations. To expand access to kidney paired donation for more patients, we propose a model to reimburse paired donation expenses analogous to the proven strategy used for over 30 years to pay for deceased donor solid organ transplantation in America.


Subject(s)
Kidney Transplantation , Tissue Donors , Tissue and Organ Procurement/economics , Humans
5.
Transplantation ; 70(5): 755-60, 2000 Sep 15.
Article in English | MEDLINE | ID: mdl-11003352

ABSTRACT

BACKGROUND: The use of expanded criteria donors (ECDs) in cadaveric renal transplantation is increasing in the US. We assess the economic impact of the use of ECDs to the Medicare end stage renal disease program. METHODS: The United Nations for Organ Sharing renal transplant registry was merged to Medicare claims data for 42,868 cadaveric renal transplants performed between 1991-1996 using USRDS identifiers. Only recipients for whom Medicare was the primary payer were considered, leaving 34,534 transplants. An ECD was defined as (1) age < or =5 or > or =55 years, (2) nonheart-beating donors, donor history of (3) hypertension or (4) diabetes. High-risk recipients (HRR) were age >60 years, or a retransplant. Medicare payments from the pretransplant dialysis period were projected forward to provide a financial "breakeven point" with transplantation. RESULTS: There were 25,600 non-HRR transplants, with 5,718 (22%) using ECDs, and 8,934 HRR transplants, of which 2,200 (25%) used ECDs. The 5-year present value of payments for non-ECD/non-HRR donor/recipient pairings was $121,698 vs. $143,329 for ECD/non-HRR pairings (P<0.0001) and, similarly was $134,185 for non-ECD/HRR pairings vs. $165,716 for ECD/HRR pairings (P<0.0001). The break even point with hemodialysis ranged from 4.4 years for non-ECD/ non-HRR pairings to 13 years for the ECD/HRR combinations but was sensitive to small changes in graft survival. Transplantation was always less expensive than hemodialysis in the long run. CONCLUSIONS: The impact of ECDs on Medicare payments is most pronounced in high-risk recipients. Cadaveric renal transplantation is a cost-saving treatment strategy for the Medicare ESRD program regardless of recipient risk status or the use of ECDs.


Subject(s)
Kidney Transplantation , Aged , Cadaver , Child, Preschool , Costs and Cost Analysis , Graft Survival/physiology , Humans , Infant , Kidney Failure, Chronic/surgery , Kidney Transplantation/economics , Kidney Transplantation/immunology , Medicare , Middle Aged , Renal Dialysis/economics , Tissue Donors
6.
Transplant Proc ; 31(1-2): 1320-1, 1999.
Article in English | MEDLINE | ID: mdl-10083588

ABSTRACT

Transplantation with EDKs is a cost-effective therapy for ESRD as compared to hemodialysis across a variety of clinical and financial scenarios. In many cases the costs of pursuing transplantation with these donors will exceed hospital reimbursement for the procedure, providing a financial disincentive to pursuing a clearly cost-effective therapy.


Subject(s)
Kidney Transplantation/economics , Tissue Donors/supply & distribution , Cadaver , Cost-Benefit Analysis , Decision Trees , Graft Survival , Humans , Kidney Failure, Chronic/economics , Kidney Failure, Chronic/surgery , Kidney Failure, Chronic/therapy , Kidney Transplantation/physiology , Kidney Transplantation/psychology , Markov Chains , Medicare , Quality of Life , Renal Dialysis/economics , Software , United States
8.
Cornea ; 7(3): 223-30, 1988.
Article in English | MEDLINE | ID: mdl-3048885

ABSTRACT

We studied two corneal specimens obtained following corneal transplantation for loss of best corrected vision after planar lamellar refractive keratoplasty. The epithelium appeared slightly undifferentiated in both cases. Peripheral bends and occasional breaks were found in the periphery of Bowman's layer. In one case there were areas of subepithelial fibrosis as well as ultrastructural fractures in Bowman's layer. The keratocyte population appeared to be slightly decreased in one case. In both specimens the optical interface contained active fibroblasts in the periphery. The planar lamellar refractive keratoplasty technique theoretically eliminates many of the adverse morphologic features encountered following the standard Barraquer cryolathe techniques, but clinical studies will be needed to determine if this form of lamellar keratoplasty is clinically superior to currently practiced techniques.


Subject(s)
Corneal Transplantation , Refractive Surgical Procedures , Aged , Aged, 80 and over , Cataract Extraction/adverse effects , Cornea/pathology , Cornea/ultrastructure , Female , Humans , Male , Microscopy, Electron , Microscopy, Electron, Scanning , Postoperative Complications , Refractive Errors/etiology , Reoperation
9.
Arch Ophthalmol ; 105(8): 1125-8, 1987 Aug.
Article in English | MEDLINE | ID: mdl-3632423

ABSTRACT

Four pairs of human eyes were operated on to correct 10 diopters of myopia. One eye underwent standard myopic keratomileusis, and the mate underwent planar lamellar refractive keratoplasty (PLRK). Cryolathing produced morphologic alterations in all layers. Planar lamellar refractive keratoplasty produced a smoother stromal surface in the optic zone. Peripheral triangular surface depressions in the lenticule, corresponding to fixation facets on the PLRK unit, were the only morphologic alterations noted. It appears that PLRK eliminates many adverse features associated with tissue freezing and lyophilization.


Subject(s)
Cornea/surgery , Cryosurgery , Myopia/surgery , Cornea/ultrastructure , Evaluation Studies as Topic , Humans , Microscopy, Electron , Microscopy, Electron, Scanning
10.
Am J Ophthalmol ; 103(3 Pt 2): 432-40, 1987 Mar 15.
Article in English | MEDLINE | ID: mdl-3826260

ABSTRACT

Using correlative microscopy and plant lectins conjugated to fluorescent dyes, we studied two human corneal specimens obtained 66 and 70 months after radial keratotomy. In one case a second radial keratotomy had been performed 11 months before we obtained the corneal specimen, which allowed us to compare wounds 11 and 66 months old in the same specimen. The 11-month-old incisions demonstrated morphologic features consistent with incomplete wound healing, whereas the incisions examined 66 and 70 months postoperatively demonstrated complete wound healing. A different lectin binding pattern of wheat germ agglutinin and concanavalin-A was observed in the 11-month-old wounds, compared with the 66-month-old wounds. Published and unpublished morphologic studies of 17 human keratotomy specimens have demonstrated incomplete wound healing up to 47 months postoperatively. The present study documents complete corneal wound healing 66 months after radial keratotomy.


Subject(s)
Cornea/ultrastructure , Keratotomy, Radial , Wound Healing , Adult , Cornea/metabolism , Female , Histocytochemistry , Humans , Lectins/metabolism , Male , Microscopy, Electron , Microscopy, Electron, Scanning , Time Factors
11.
Arch Ophthalmol ; 105(1): 63-9, 1987 Jan.
Article in English | MEDLINE | ID: mdl-3541870

ABSTRACT

We performed a morphologic analysis of nine epikeratoplasty lenticules that were removed due to nonhealing epithelial defects, interface opacity, and/or haze of the donor lenticule. Structural abnormalities were found in all layers of the donor lenticules, with the major changes being present in the surface epithelium and Bowman's layer. Significant changes in the stromal collagen were documented. Similar changes were found in a previous analysis of never-used, factory-prepared lenticules that had been prepared following the use of a corneal press and a lyophilization process. This study suggests that the presently used process of tissue preparation may be deleterious to the structure of the donor lenticule and may adversely affect surface reepithelialization. The placement of the lenticule above the recipient's Bowman layer may be an additional retardant to postoperative reepithelialization.


Subject(s)
Corneal Transplantation , Graft Survival , Adult , Aged , Biomechanical Phenomena , Cornea/pathology , Cornea/ultrastructure , Female , Humans , Infant , Male , Microscopy, Electron , Wound Healing
12.
Arch Ophthalmol ; 104(5): 671-9, 1986 May.
Article in English | MEDLINE | ID: mdl-3518679

ABSTRACT

A correlative microscopic analysis of factory-prepared epikeratoplasty lenticules, corneas stored in McCarey-Kaufman medium for two to four days, and fresh human corneas disclosed ultrastructural abnormalities in Bowman's membrane and in the corneal stroma of the lyophilized lenticules that were not present in the control corneas. These features included mottling of Bowman's membrane, with large interfibrillar spaces; a roughness to its surface; and wide interlamellar lacunae within the corneal stroma, with significant changes in interfibrillar collagen distance and fibril diameter. The morphologic features of a clinical specimen excised three months following myopic epikeratoplasty were similar to those found with the factory-prepared lenticules. Our patient's corneal curvature steepened almost 3 diopters following lenticule removal. Our results suggest that additional studies of lyophilized epikeratoplasty lenticules should be performed.


Subject(s)
Corneal Transplantation , Cornea/pathology , Cornea/ultrastructure , Epithelium/ultrastructure , Female , Freeze Drying , Humans , Middle Aged , Myopia/pathology , Organ Preservation , Refraction, Ocular , Visual Acuity
14.
Ophthalmology ; 92(6): 734-40, 1985 Jun.
Article in English | MEDLINE | ID: mdl-4034168

ABSTRACT

Four human corneal specimens obtained 5 to 47 months following radial keratotomy were evaluated by correlative microscopy. Repeat radial keratotomies had been performed in two cases. We documented gaping keratotomy incisions, epithelial plugs, and epithelial-lined incisions. In all cases, Bowman's layer was malapposed with slight to moderate fibroblastic activity at the incision sites. Epithelial and endothelial radial ridges were seen in two cases. No endothelial damage was seen under the radial incisions. The morphological evaluation of these specimens show the potential for a poor wound-healing response when corneas with previous corneal surgery and/or pathologic states undergo radial keratotomy.


Subject(s)
Cornea/surgery , Wound Healing , Adult , Cornea/ultrastructure , Humans , Male , Microscopy, Electron, Scanning , Postoperative Complications , Time Factors
17.
Arch Ophthalmol ; 102(11): 1671-5, 1984 Nov.
Article in English | MEDLINE | ID: mdl-6388544

ABSTRACT

We performed 11 keratophakia procedures in a baboon (Papio cynocephalus) model using the same instruments and techniques that are presently clinically employed. We requested 10 diopters of correction in nine cases and 14 D in two cases. We were able to achieve a mean (+/- SD) keratometric steepening correction of 5.8 +/- 1.5 D using fresh and 9.3 +/- 5.0 D using prefrozen donor corneas. The overall change was 8.0 +/- 4.3 D. Morphologic results and corneal clarity were consistent with the excellent clinical results. The keratophakia lenticles were sparsely repopulated with keratocytes up to six months following surgery, but at 12 months, partial keratocyte repopulation of one lenticle did occur. We recommend that the baboon model be used for evaluation of all lamellar refractive surgical procedures.


Subject(s)
Corneal Transplantation , Refraction, Ocular , Animals , Cornea/physiology , Cornea/ultrastructure , Disease Models, Animal , Evaluation Studies as Topic , Female , Methods , Microscopy, Electron , Microscopy, Electron, Scanning , Papio
18.
Curr Eye Res ; 3(10): 1187-97, 1984 Oct.
Article in English | MEDLINE | ID: mdl-6386345

ABSTRACT

We performed 8 myopic keratomileusis procedures in a baboon (Papio cynocephalus) model using the same instruments and techniques which are presently clinically employed. We requested 10 diopters of refractive correction and were able to achieve a mean keratometric correction of 5.5 diopters (range 2.4-8.4) in 6 eyes. Keratometric data in the two remaining eyes was not obtained, because of distortion of corneascope photographs. We did not encounter any technical problems at surgery or during the 2-1/2 to 6 month postoperative period of followup. Morphologic analysis demonstrated subclinical, focal breaks in Bowman's membrane in all specimens and keratocyte repopulation in 7 of 8 eyes. We did find a wide range in the central thickness of the excised corneas which can account for the undercorrections achieved. We consider the baboon model to be excellent for the evaluation of myopic keratomileusis.


Subject(s)
Corneal Transplantation , Myopia/surgery , Refraction, Ocular , Animals , Collagen/metabolism , Cornea/pathology , Endothelium/pathology , Epithelium/pathology , Female , Freezing , Microscopy, Electron, Scanning , Microsurgery/methods , Papio , Wound Healing
19.
Curr Eye Res ; 3(10): 1253-62, 1984 Oct.
Article in English | MEDLINE | ID: mdl-6488854

ABSTRACT

We have developed an in-vitro model for keratocyte interactions with hydrogel materials. With the aid of inverted phase contrast microscopy and scanning electron microscopy, we observed the growth of baboon stromal keratocytes on the surface of various hydrogel materials. In this study, the Bioflex lens (0.5% hydration) surface was extensively covered with keratocytes, whereas 1% to 25% of the surfaces of Crofilcon A (40% hydration) and Perfilcon A (70% hydration) lenses were covered with keratocytes. The Bufilcon A (55% hydration) lens was free of keratocyte attachment. Keratocytes attached to the surfaces of the lenses produced extracellular collagenous material as evidenced by positive staining with alcian green-metanil yellow. These in-vitro results correlate with our non-human primate studies using Bioflex, Crofilcon A and Bufilcon A lenses as intracorneal implants.


Subject(s)
Cornea/cytology , Lenses, Intraocular , Animals , Cell Adhesion , Cell Differentiation , Cells, Cultured , Endothelium/cytology , Epithelial Cells , Microscopy, Electron, Scanning , Papio
20.
Invest Ophthalmol Vis Sci ; 25(7): 843-50, 1984 Jul.
Article in English | MEDLINE | ID: mdl-6376415

ABSTRACT

The pathology of 14 keratophakia procedures in nine nonhuman primates using various hydrogel lenses as donor lenticles is presented. The lenses were treated as if they were human donor corneas using currently practiced keratophakia procedures. This included microkeratome resection of the recipient cornea, staining of the lenses before cryolathing and, in most instances, lathing according to a modified computer program after which the lenses were inserted into the previously dissected recipient lamellar bed. There was no histologic evidence of an inflammatory reaction to the hydrogels. The major pathologic feature was the presence of activated keratocytes lining the dissected intrastromal pockets.


Subject(s)
Contact Lenses, Hydrophilic , Corneal Transplantation , Lenses, Intraocular , Animals , Cornea/ultrastructure , Cytoplasm/ultrastructure , Epithelium/ultrastructure , Female , Microscopy, Electron , Microscopy, Electron, Scanning , Organoids/ultrastructure , Papio
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