ABSTRACT
Erythrocytes and platelets phospholipid membranes fatty acid spectrum was detected in coronary heart disease and atrial fibrillation patients and in patients with coronary heart disease without atrial fibrillation. 87 patients were investigated. Significant decrease in the arachidonic acid relative content in coronary heart disease patients compared with healthy individuals was related. As well as a significant decrease in the arachidonic acid relative content in coronary heart disease and atrial fibrillation patients compared with coronary heart disease patients without atrial fibrillation was related too. These dates may indicate that decreasing relative content arachidonic acid can be possible pathogenetic link in the development of arrhythmias.
Subject(s)
Arachidonic Acid/analysis , Atrial Fibrillation/blood , Cell Membrane/chemistry , Coronary Artery Disease/blood , Fatty Acids/analysis , Phospholipids/analysis , Aged , Aged, 80 and over , Arachidonic Acid/metabolism , Atrial Fibrillation/complications , Atrial Fibrillation/pathology , Blood Platelets/chemistry , Blood Platelets/metabolism , Case-Control Studies , Cell Membrane/metabolism , Chromatography, Gas , Coronary Artery Disease/complications , Coronary Artery Disease/pathology , Erythrocytes/chemistry , Erythrocytes/metabolism , Fatty Acids/metabolism , Female , Humans , Male , Middle Aged , Phospholipids/metabolismABSTRACT
The study involved 65 progressive angina patients (PA) aged 67 to 73 years. Determination of lymphocytes population and subpopulation was performed by monoclonal antibodies. Immunoglobulin G, A, M and circulating immune complexes (CIC) determination in the blood serum was performed by the Mancini method. The results showed that the clopidogrel with aspirin (aspihrel) combination in the basic treatment of PA patients is more effective than the basic treatment that included only clopidogrel, as evidenced by the positive trend of more indicators of immune status of patients.
