ABSTRACT
Patients with acute myelogenous leucosis with toxic damage of the liver against polychemotherapy have an expressed disbalance in the lipid peroxidation-anti-oxidant system, which is possible to correct effectively using S-adenozilmetionin (heptral) was observed.
Subject(s)
Antioxidants/metabolism , Antioxidants/therapeutic use , Chemical and Drug Induced Liver Injury/drug therapy , Leukemia, Myeloid, Acute/metabolism , Lipid Peroxidation/drug effects , Adult , Antioxidants/administration & dosage , Catalase/blood , Catalase/metabolism , Chemical and Drug Induced Liver Injury/enzymology , Chemical and Drug Induced Liver Injury/metabolism , Glutathione Peroxidase/blood , Glutathione Peroxidase/metabolism , Glutathione Reductase/blood , Glutathione Reductase/metabolism , Humans , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid, Acute/enzymology , Lipid Peroxides/blood , Lipid Peroxides/metabolism , Phospholipids/administration & dosage , Phospholipids/therapeutic use , S-Adenosylmethionine/administration & dosage , S-Adenosylmethionine/therapeutic use , Superoxide Dismutase/blood , Superoxide Dismutase/metabolism , Treatment OutcomeSubject(s)
Air Pollutants, Occupational/toxicity , Furans/toxicity , Animals , Brain/drug effects , Furans/blood , Furans/metabolism , Lethal Dose 50 , Liver/drug effects , Male , RatsABSTRACT
The biotic doses of trace elements (iron, copper, and manganese) contained by hemostimulin exert a favourable effect on working capacity of athletes, hemopoiesis, catalase and ceruloplasmin activity as well as on transferrin saturation with iron.
Subject(s)
Ascorbic Acid/administration & dosage , Copper/administration & dosage , Ferrous Compounds/administration & dosage , Iron/administration & dosage , Manganese/administration & dosage , Physical Endurance/drug effects , Sports Medicine , Adolescent , Blood/drug effects , Drug Combinations , HumansABSTRACT
Effect of some furan compounds--monofurfurilidene acetone (MFA), difurfurilidene acetone (DIFA), furyl alcohol (Fal) and furfurol (Fl)--on peroxidation of unsaturated fatty acids in lipids was studied in subcellular organelles of rat liver cells in vitro. By the rate of inhibition of lipid peroxidation the substances studied were arranged as follows: DIFA--100%, Fal--65%, Fl--27% and MFA--1-2%. The furan derivatives at the concentration 10(-2) M effectively inhibited the lipid peroxidation in subcellular organelles, especially in mitochondrial and microsomal fractions.
