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Carcinogenic effect of an antitumor drug etoposide in laboratory animals.
Fomina, T I; Perelmuter, V M; Vtorushin, S V; Zavjalova, M V; Borovskaja, T G; Timina, E A.
Bull Exp Biol Med ; 144(5): 725-7, 2007 Nov.
Article in English | MEDLINE | ID: mdl-18683507

ABSTRACT

Intravenous injection of antitumor drug etoposide in the maximum tolerated dose was followed by the development of breast cancer in 38.1% female Wistar rats and 6.7% female outbred mice.


Subject(s)
Antineoplastic Agents/toxicity , Breast Neoplasms/pathology , Etoposide/toxicity , Animals , Antineoplastic Agents/administration & dosage , Breast Neoplasms/chemically induced , Etoposide/administration & dosage , Female , Injections, Intravenous , Mice , Rats , Rats, Wistar
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