ABSTRACT
AIM: To study the spread of a number of indicators of subclinical atherosclerosis in patients with coronary heart disease (CHD) and the pattern of their relationship to their functional state and muscle mass. SUBJECTS AND METHODS: Twenty patients with chronic forms of CHD were examined. Vascular wall stiffness was judged from pulse wave velocity (PWV) along elastic-type vessels, by calculating the carotid-femoral index (CFI). Endothelial function was estimated by endothelium-dependent vasodilation (EDV) in a reactive hyperemia test. Ultrasound scanning of the common carotid artery was used to estimate intima-media thickness. All the patients underwent bicycle ergometry; their exercise tolerance (ET) was determined by the amount of consumed oxygen when the metabolic equivalent (MET) was calculated; the percentages of active cell mass (ACM%) and lean mass (LM%) of total body weight were determined; the levels of total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides were estimated. A control group comprised 20 matched persons without CHD. RESULTS: A prognostically unfavorable increase of >12 m/sec in CFI was revealed in 20% of the patients with CHD and in 10% of the controls; endothelial vasomotor dysfunction (EDV < 10%) in 65 and 50%; a more than 0.9-mm increase in 55 and 15%, respectively. A low ET was stated in the majority of patients with abnormal vascular stiffness and endothelial vasomotor dysfunction. The CHD patients with a low ET were found to have significant correlations of CFI with ACM% and LM%, EDV and ACM% and LM%, CFI and EDV. The control patients with a low ET also showed correlations of EDV and ACM% and LM%. There was a correlation of ACM% and LM% with MET in both groups. CONCLUSION: EDV and PWV reflect a more decrease in physical activity and dysadapted functional status than in the degree of subclinical atherosclerosis.
Subject(s)
Atherosclerosis/physiopathology , Coronary Disease/physiopathology , Exercise Tolerance/physiology , Vascular Stiffness/physiology , Vasodilation/physiology , Atherosclerosis/diagnosis , Brachial Artery/diagnostic imaging , Brachial Artery/physiopathology , Carotid Arteries/diagnostic imaging , Carotid Arteries/physiopathology , Carotid Intima-Media Thickness , Coronary Disease/diagnosis , Female , Humans , Male , Middle AgedABSTRACT
Study the influence of ration different content of fat the pain syndrome in osteoarthrosis with the knee joint. We examined 112 women at the age 59 (54-63) with osteoarthrosis the knee joint. Elicit what plenty in ration of fat (more than 45% caloric intake) promote the aggravation pain syndrome in the knee joint in osteoarthrosis patients.
Subject(s)
Dietary Fats/adverse effects , Energy Intake , Osteoarthritis, Knee/physiopathology , Pain/physiopathology , Dietary Fats/administration & dosage , Female , Humans , Middle Aged , Osteoarthritis, Knee/pathology , Pain/pathology , SyndromeABSTRACT
The purpose of the study was to determine the degree of influence of physical exercises on endothelial dysfunction in patients with chronic articulation inflammatory diseases on the example of rheumatoid arthritis (RA) and osteoarthritis (OA). 41 patients with chronic articulation inflammatory diseases were examined. Endothelial dysfunction was detected in 37% OA patients and 77% RA patients. The results of the study show significantly higher degree of influence of physical exercises on endothelial dysfunction in comparison with drug therapy.
