[OSTEOPOROSIS IN MEN: CURRENT ISSUES].

Analysis of outpatients male patients aimed at Bone Density Measurement (Dual-Energy X-Ray Absorptiometry) during 2013. The study shows that men are sent to the examination for osteoporosis nearly 20 times less than women, while in men older than 60 years the decrease in bone mineral density was observed in more than 85% of cases. The identified violations of mineralization of bone tissue in men in different age periods and the main reason for referral for examination were analyzed.

[Prognostic value of leptin level detection in industrial workers suffering from osteoarthrosis in Volgograd].

Study of 130 osteoarthrosis patients revealed high serum level of leptin in 42 (32.3 %) patients including 9 males and 33 females. Osteoarthrosis patients with high serum leptin level are characterized by more severe course of the disease.

[Detecting adiponectin in industrial workers having inflammatory diseases of joints].

Examination of 55 patients with rheumatoid arthritis revealed low serum level of adiponektin in 25.4 % of the patients. Patients with low serum level of adiponektin demonstrate such symptoms set as: increased activity degree on DAS28 (II-III activity grade), high level of antibodies to citrullinated vimentin, advanced and late stages of the disease, severe X-ray changes.

[Efficiency of unsaponifiable compounds of soya beans and avocado in health care personnel with osteoarthrosis in Volgograd].

The authors used immunoenzyme method to assess level of oxydated low density lipoproteins (o-LDL) in 130 patients with osteoarthrosis. High serum level of o-LDL was seen in 60% of the patients with osteoarthrosis. 40 patients with osteoarthrosis were treated by unsaponifiable compounds of soya beans and avocado (Piaskledin, Expanscience, France)--dose of 300 mg daily, over 3 months. The treatment resulted in good effect in the patients with high level of o-LDL (over 168 ng/ml).

[The relation between the level of antibodies to the glycosaminoglycans of the cartilage in patients with osteoarthritis and the efficacy of treatment with chondroprotectors]. / Sviaz' urovnia antitel k glikozaminoglikanam khriashcha u bol'nykh osteoartrozom s éffektivnost'iu lecheniia khondroprotektorami.

AIM: To improve the efficacy of osteoarthrosis (AO) treatment by chondroprotectors by defining individual indications for their use, based on the initial level of antibodies to cartilaginous glycosaminoglycans (GAG) in the blood serum. MATERIALS AND METHODS: Anti-GAG were detected by indirect solid-phase enzyme immunoassay. The antigen was a sulfated GAG preparation GAG-polysulfate (arteparon) manufactured by Luitpold-Werk (Germany). Sera of 110 OA patients were tested. Fifty of them were treated by rumalon, 20 with arteparon, and protocols of 40 patients included no chondroprotectors. RESULTS: The highest levels of anti-GAG were found in OA patients with multiple involvement of the joints, rapidly progressing disease, and secondary synovitis. The titer of antibodies increases with disease duration and in patients with the roentgenological stage of OA, reaching the maximum by 10-15 years of disease or by stage III. Efficacy of chondroprotectors was lower at lower levels of antibodies to cartilaginous GAG. CONCLUSION: Chondroprotector therapy of patients with initially high levels of antibodies to GAG is unadvisable, for it can lead to exacerbations, specifically, to secondary synovitis.

[Efficacy of D-penicillamine and methotrexate in the treatment of rheumatoid arthritis in relation to levels of circulating rheumatoid factors of different classes]. / Effektivnost' D-penitsilamina i metotreksata pri lechenii revmatoidnogo artrita v zavisimosti ot urovnia revmatoidnykh faktorov raznykh klassov.

AIM: To optimize treatment for rheumatoid arthritis (RA) and to define indications for D-penicillamine and methotrexate therapies on an individual basis by taking into account the levels of rheumatoid factor (RF) isotopes circulating in blood. MATERIALS AND METHODS: A total of 105 patients (mean age 46.39 +/- 1.35 years) with varying RA were observed. Indirect solid-phase enzyme immunoassay was used to analyze RF isotopes; the pattern of the disease and the efficiency of therapy for RA were compared with the patients' immunity. RESULTS: With elevated RF IgG levels, the cardiovascular system, thyroid, mucous membranes were found to be more frequently impaired and vasculitis was diagnosed. CONCLUSION: The use of cuprenil and methotrexate in RA substantially improves patients' immunity.

[Immobilized granulated drugs with magnetic properties based on nDNA, RNA, cardiolipin in the diagnosis and treatment of systemic lupus erythematosus]. / Immobilizovannye granulirovannye preparaty s magnitnymi svoistvami na osnove nDNK, RNK, kardiolipina v diagnostike i lechenii sistemnoi krasnoi volchanki.

To advance diagnosis and treatment of systemic lupus erythematosus (SLE), the authors have developed a number of specific diagnostic preparations basing on nDNA, RNA, cardiolipin immobilized into the three-dimensional lattice of polyacrylamide gel. Using such granulated antigenic preparations with magnetic properties, a correlation has been derived between SLE activity, visceral pathology and a level of specific antibodies. In view of a successful experimental use of the preparations as selective sorbents, they may be introduced into extracorporeal treatment. Immobilized granulated preparations can be used in immunofluorescent tests and enzyme immunoassays.