ABSTRACT
Stromal microinvasion in ovarian serous borderline tumors can take various aspects, some of which are difficult to identify. Thus, the identification of stromal microinvasion is relatively simple for typical intracystic papillary proliferations such as serous borderline tumors, but may be difficult for tumors with glandular component. The study analyzed 14 cases of ovarian serous borderline tumors diagnosed in patients with mean age of 47,1 years. Histopathologically all tumors corresponded to typical forms in which we identified only two cases of stromal microinvasion. In one case, microinvasion was of eosinophilic type, and in the other case was observed a glandular and micropapillary pattern, being associated with the noninvasive peritoneal implants.
ABSTRACT
The epithelial growth factor receptor (EGFR) is involved in various stages of cancer growth such as tumor initiation, angiogenesis and metastasis, being an attractive target for oncogenic therapy. The present study aims to evaluate the EGFR expression in 54 cases of serous and mucinous ovarian borderline tumors and carcinomas. EGFR expression was present in more than half of the investigated tumors, more frequently in carcinomas than in borderline tumors, especially in the serous type. The highest values of the final staining score (FSS) were observed only in serous carcinomas in the advanced stages of the disease. As a result of frequent expression of EGFR in ovarian tumors, it is necessary to monitor EGFR inhibitors for ovarian cancer therapy, but probably after establishing more rigorous selection and stratification criteria for patients.
ABSTRACT
Traumatic brain injury (TBI) represents a common cause of presentation in the emergency room and is considered a major health problem all over the world. Our study objective was to provide a regional perspective from a county hospital regarding epidemiologic aspect of TBI in a single year and to compare it with existing studies. 592 patients fulfilled the inclusions criteria and their characteristics were noted. We observed that the highest rate of TBI was among older people with an age over >60 years with 40.88%, which represented 242 of cases. Middle age adults (40 to 60 years) represented 34.29% whereas young adults were 16.72%. The remaining cases of 8.11% suffered mostly of concussions (80%) and were encountered in the <20 years group. While comparing with the local population of the Dolj County we obtained an incidence of 89.6 per 100.000 people. When discussing gender, we observed that most of the patients were male with a ratio of 2,3:1. Over one year, 132 deaths were cause of TBI, with most of them being related to older age 55.71%, followed by the middle age adults with 37.93%. Direct cost was also assessed with 894.110.523 which represents more than 200.000 euro. Medium cost per patient was 6.296.552 RON, 1414 euro, with most of the patients having a medium admission of 10 days. TBI represents a major problem and perhaps a better assessment and a national program will help enhance the treatment quality and might also help reduce the cost.
ABSTRACT
Appendiceal anomalies are extremely rare malformations. We presented the case of a patient 43-year-old who had undergone emergency surgery for bowel occlusion. Incidentally we have found an "horseshoe-shaped" appendix which removed. After review of the literature we have introduced this appendiceal variant in a complete classification of appendiceal anomalies.
