ABSTRACT
The authors describe the case of male patient of 46 years old, which was diagnosticated with 4 cancers of different localization and histopathological types in the course of 6 years. In chronological order these 4 neoplazias were: the Hodgkin's disease with mixed cellularity, the malign parieto-frontal right meningioma, a Grawitz renal tumor and a lung adenocarcinoma with bilateral lung and pleural metastasis. For both cerebral and renal tumors the patient was given a surgical treatment and for the Hodgkin's disease and lung cancer given chemotherapy and cobalt therapy.
Subject(s)
Neoplasms, Multiple Primary , Adenocarcinoma/pathology , Adenocarcinoma/therapy , Carcinoma, Renal Cell/pathology , Carcinoma, Renal Cell/therapy , Hodgkin Disease/pathology , Hodgkin Disease/therapy , Humans , Kidney Neoplasms/pathology , Kidney Neoplasms/therapy , Lung Neoplasms/pathology , Lung Neoplasms/therapy , Male , Meningeal Neoplasms/pathology , Meningeal Neoplasms/therapy , Meningioma/pathology , Meningioma/therapy , Middle Aged , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/therapy , Treatment OutcomeABSTRACT
Diabetes mellitus involves the lungs in the course of the complex phenomena it generates. Recent research in animal diabetes as well as in human diabetes demonstrated biochemical changes at the pulmonary level such as the suppression of anyline p-hydroxilase, the reduction of the activity of glutathione-peroxidase, the development of NO-dependent endothelial dysfunction, microsomal disorders, increased heparan sulphate at the level of the vascular basement membrane, increased levels of advanced glycation end-products and the derangement of bronchial mucus production by amyline. Structural modifications of the lung parenchyma were observed such as the narrowing of the alveolar space, the flattening of the alveolar epithelium and the expansion of the interstitium. Aside from the involvement of the pulmonary vessels there is the involvement of the basement membranes of the alveolar epithelium, the bronchial epithelium and the pulmonary capillaries. The consequences of local oxidative stress, the increased vascular permeability and the modifications in mucus secretion lead to the reduction of pulmonary volumes, pulmonary diffusion capacity, elastic recoil with involvement of restrictive lung disorders, diminished bronchial reactivity and diminished bronchodilatation. Data of pulmonary pathology obtained from patients as well as pulmonary involvement of children born of diabetic mothers are presented succinctly.
Subject(s)
Diabetes Mellitus/pathology , Diabetes Mellitus/physiopathology , Lung/pathology , Animals , Basement Membrane/pathology , Cystic Fibrosis/complications , Diabetes Complications , Endothelium, Vascular/pathology , Glycation End Products, Advanced/metabolism , Humans , Lung Diseases/pathology , Lung Diseases/physiopathology , Pulmonary Alveoli/pathology , Pulmonary Alveoli/physiopathology , Respiratory Tract Infections/pathology , Respiratory Tract Infections/physiopathologyABSTRACT
The authors describe a case of vertebral tuberculosis with multiple localizations, high thoracical (T2-T6) and of the sacrum (S1-S4) at a young woman with nonspecific clinical symptoms and with CT examination suggestive of the diagnosis, where the diagnostical certainty was obtained by the bacteriological examination for bK of the pus (purulent liquid) extracted by CT guided fine needle biopsy performed in the posterior mediastinal tumor.
