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Zh Vyssh Nerv Deiat Im I P Pavlova ; 66(5): 556-564, 2016 09.
Article in Russian | MEDLINE | ID: mdl-30695401

ABSTRACT

We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. It has been shown that Val66Met and 5-HTTLPR polymorphisms are associated with P100 and N170 during the passive reading of single words written in Russian presented with different occurrence frequency. The healthy carriers of the ValVal genotype (BDN F Val66Met) allele or the SS (5-HTTLPR) genotype performed the task better compared to those with an Met or an L allele. The differences were significant in healthy people and observed as a trend in thepatients.


Subject(s)
Brain-Derived Neurotrophic Factor/genetics , Evoked Potentials, Auditory/physiology , Psychotic Disorders/genetics , Schizophrenia/genetics , Schizotypal Personality Disorder/genetics , Serotonin Plasma Membrane Transport Proteins/genetics , Speech Perception/physiology , Adolescent , Adult , Alleles , Case-Control Studies , Cognition/physiology , Female , Gene Expression , Humans , Male , Middle Aged , Polymorphism, Genetic , Psychotic Disorders/diagnostic imaging , Psychotic Disorders/physiopathology , Russia , Schizophrenia/diagnostic imaging , Schizophrenia/physiopathology , Schizotypal Personality Disorder/diagnostic imaging , Schizotypal Personality Disorder/physiopathology , Speech/physiology
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