ABSTRACT
Adult hepatoblastoma is a rare pathology. Its pathogeny is not well understood and prognosis is very bad. We pre-sent a case of adult hepatoblastoma treated in our centre. A 65 year-old male, without previous hepatopathy, who consulted due to right hypochondrial pain with a subacute evolution. The pathological diagnosis was adult epithelial hepatoblastoma, with free surgical margins. The patient recei-ved a second surgical intervention 5 months later due to early recurrence and died 10 months after the diagnosis due to a new massive recurrence. His definitive diagnosis is histological. Radical surgery is the only treatment that increases survival, but recurrence is frequent. There are no well-defined patterns of adjuvant chemotherapy nor is there any trans-plant experience.
Subject(s)
Hepatoblastoma , Liver Neoplasms , Aged , Hepatoblastoma/diagnosis , Hepatoblastoma/surgery , Humans , Liver Neoplasms/diagnosis , Liver Neoplasms/surgery , MaleABSTRACT
El hepatoblastoma del adulto es una patología inusual, de patogenia no bien conocida y de muy mal pronóstico. Presentamos un caso de hepatoblastoma del adulto tratado en nuestro centro. Varón de 65 años, sin hepatopatía previa, que consulta por dolor en hipocondrio derecho de evolución subaguda. El diagnóstico anatomopatológico fue hepatoblastoma epitelial del adulto, con bordes quirúrgicos libres. Fue reintervenido 5 meses después por recidiva precoz y falleció 10 meses después del diagnóstico por nueva recidiva masiva. Su diagnóstico definitivo es histológico. La cirugía radical ofrece el único tratamiento que aumente la supervivencia, pero frecuentemente recidiva. No existen pautas bien definidas de quimioterapia adyuvante, ni experiencia en trasplante (AU)
Adult hepatoblastoma is a rare pathology. Its pathogeny is not well understood and prognosis is very bad. We present a case of adult hepatoblastoma treated in our centre. A 65 year-old male, without previous hepatopathy, who consulted due to right hypochondrial pain with a subacute evolution. The pathological diagnosis was adult epithelial hepatoblastoma, with free surgical margins. The patient received a second surgical intervention 5 months later due to early recurrence and died 10 months after the diagnosis due to a new massive recurrence. His definitive diagnosis is histological. Radical surgery is the only treatment that increases survival, but recurrence is frequent. There are no well-defined patterns of adjuvant chemotherapy nor is there any transplant experience (AU)
Subject(s)
Humans , Male , Aged , Hepatoblastoma/diagnosis , Neoplasm Recurrence, Local/complications , Liver Neoplasms/diagnosis , Hepatoblastoma/pathology , Abdomen, Acute/etiologyABSTRACT
Angiosarcoma of the gallbladder is an infrequent pathology but has a high morbidity and mortality. There are only 10 references in the international literature. We present a case treated in our center and we review the cases published since 1956. An 81 year-old male patient with abdominal pain, asthenia and dyspnea. Analytically anemia and leukocytosis. Exploration found a distended abdomen, right hypochondrium pain, with defense. Abdominal echography and a CT were requested with a diagnosis of acute cholecystitis and he was admitted for antibiotic treatment. The patient did not evolve favorably and was subjected to emergency surgery, which found a haemoperitoneum and a gallbladder with a tumoral appearance that could not be totally extirpated. He died 20 days after the operation. The report from pathological anatomy was compatible with epithelioid angiosarcoma of the biliary gallbladder. Gallbladder angiosarcoma is a neoplasia with a bad prognosis, whose clinical presentation can be mistaken for acute cholecystitis. Improving the prognosis of this disease involves carrying out early diagnosis and surgical treatment.
Subject(s)
Gallbladder Neoplasms/diagnosis , Hemangiosarcoma/diagnosis , Aged, 80 and over , Gallbladder Neoplasms/surgery , Hemangiosarcoma/surgery , Humans , Male , PrognosisABSTRACT
El angiosarcoma de vesícula es una patología poco frecuente pero con una alta morbi-mortalidad del que sólo hay 10 referencias en la literatura internacional. Presentamos un caso tratado en nuestro centro y realizamos una revisión de los casos publicados desde 1956. Paciente varón de 81 años con dolor abdominal, astenia y disnea. Analíticamente anemia y leucocitosis. En la exploración destacaba un abdomen distendido, doloroso en hipocondrio derecho, con defensa. Se solicitó ecografía abdominal y un TC con diagnóstico de colecistitis aguda y se ingresó para tratamiento antibiótico. El paciente no evolucionó favorablemente y se intervino de urgencia hallando un hemoperitoneo y una vesícula de aspecto tumoral que no se pudo extirpar en su totalidad. Falleció a los 20 días de la intervención. El informe de anatomía patológica fue compatible con angiosarcoma epiteloide de vesícula biliar. El angiosarcoma de vesícula es una neoplasia de mal pronóstico, cuya presentación clínica puede confundirse con la colecistitis aguda. Conseguir mejorar el pronóstico de esta enfermedad pasa por realizar un diagnóstico y tratamiento quirúrgico precoces (AU)
Angiosarcoma of the gallbladder is an infrequent pathology but has a high morbidity and mortality. There are only 10 references in the international literature. We present a case treated in our center and we review the cases published since 1956. An 81 year-old male patient with abdominal pain, asthenia and dyspnea. Analytically anemia and leukocytosis. Exploration found a distended abdomen, right hypochondrium pain, with defense. Abdominal echography and a CT were requested with a diagnosis of acute cholecystitis and he was admitted for antibiotic treatment. The patient did not evolve favorably and was subjected to emergency surgery, which found a haemoperitoneum and a gallbladder with a tumoral appearance that could not be totally extirpated. He died 20 days after the operation. The report from pathological anatomy was compatible with epithelioid angiosarcoma of the biliary gallbladder. Gallbladder angiosarcoma is a neoplasia with a bad prognosis, whose clinical presentation can be mistaken for acute cholecystitis. Improving the prognosis of this disease involves carrying out early diagnosis and surgical treatment (AU)
Subject(s)
Aged, 80 and over , Humans , Male , Sarcoma/complications , Sarcoma/surgery , Sarcoma , Gallbladder/pathology , Gallbladder/surgery , Gallbladder , Gallbladder Neoplasms/complications , Gallbladder Neoplasms , Indicators of Morbidity and Mortality , Abdominal Pain/etiology , Abdominal Pain , Tomography, Emission-Computed , Gallbladder Neoplasms/physiopathology , Gallbladder Neoplasms/surgery , Cholecystitis/complications , CholecystitisABSTRACT
Introducción. La afectación del margen circunferencial (MC) en los pacientes intervenidos por neoplasia de recto es un factor de mal pronóstico en cuanto a posibilidad de recidiva local, recidiva a distancia y supervivencia, y esta afectación se ha relacionado con la calidad de la cirugía. Analizamos la tasa de afectación del MC en pacientes con cáncer de recto localmente avanzado, sometidos a tratamiento neoadyuvante, y su relación con la supervivencia libre de enfermedad (SLE) y la supervivencia específica (SE). Material y métodos. Se incluye a 101 pacientes diagnosticados de adenocarcinoma de recto entre enero de 2001 y diciembre de 2005, e intervenidos tras recibir radioquimioterapia neoadyuvante. El MC se consideró positivo cuando la distancia del tumor al borde quirúrgico fue menor de un milímetro. La afectación del MC se relaciona con la SLE y la SE mediante el test log-rank. Resultados. La media de edad fue de 66,6 años. La tasa de afectación del MC fue del 10,8% (11 casos), en 7 casos por cercanía o contacto del MC con el tumor, en 2 por cercanía de adenopatías, en un caso por infiltración perineural en el MC y en otro por crecimiento discontinuo del tumor. Con un seguimiento medio de 25,4 meses, se diagnosticó recidiva de la enfermedad en 13 pacientes: en 3 (2,97%) como recidiva local y en 10 (9,9%) como metástasis a distancia. Once (10,8%) pacientes fallecieron por evolución de la enfermedad. La afectación del MC se relacionó significativamente con la SLE (p = 0,0167) y con la SE (p = 0,0176). Conclusión. En pacientes intervenidos por cáncer de recto después de tratamiento neoadyuvante con radioquimioterapia, la afectación del MC es un factor pronóstico negativo para SLE y SE (AU)
Introduction. Circumferential resection margin (CRM) involvement in patients undergoing surgery for rectal tumors is a factor predicting poor prognosis in terms of the possibility of local recurrence, distant recurrence, and survival. CRM involvement has been related to the quality of the surgery. We analyzed the rate of CRM involvement in patients with locally-advanced rectal cancer undergoing neoadjuvant therapy and its relation with disease-free survival (DFS) and disease-specific survival (DSS). Material and methods. A total of 101 patients diagnosed with rectal adenocarcinoma between January 2001 and December 2001 who underwent surgery after receiving neoadjuvant radiochemotherapy were included. The CRM was considered positive when the distance between the tumor and the surgical border was less than 1 mm. The relation between CRM involvement and DFS and DSS was evaluated using the log-rank test. Results. The mean age was 66.6 years. The rate of CRM involvement was 10.8% (11 patients); CRM involvement was due to proximity or contact of the CRM with the tumor in 7 patients, proximity of enlarged nodes in 2 patients, perineural invasion in the CRM in 1 patient and discontinuous tumoral growth in 1 patient. With a mean follow-up of 25.4 months, disease recurrence was diagnosed in 13 patients: local recurrence occurred in 3 (2.97%) patients and distant metastases in 10 (9.9%). Eleven (10.8%) patients died from disease progression. CRM involvement was significantly related to DFS (p = 0.0167) and DSS (p = 0.0176). Conclusion. In patients undergoing surgery for rectal cancer after neoadjuvant radiochemotherapy, CRM involvement is a negative prognostic factor for DFS and DSS (AU)
