ABSTRACT
UNLABELLED: The purpose of the study was to evaluate the influence of steroid therapy on endoscopic picture of gastric mucosa. The study comprised 22 children (17 boys and 5 girls) with the nephrotic syndrome aged 4-12 years (the mean 9 years) treated with prednisone. Children were divided into two groups taking into account duration of therapy. The group I (10 children) comprised patients with therapy duration not exceeding 3 months. The group II (12 children) comprised children treated 5 years in average. All patients underwent gastroscopic examination. Macro and microscopic lesions of gastric mucosa, their intensity and coexistence of Helicobacter pylori (HP) infection were estimated. CONCLUSIONS: 1. In nephrotic children during prednisone therapy different types of gastric and duodenal mucosal inflammatory changes occur. 2. Duration of prednisone therapy does not influence significantly on location, type and severity of mucosal inflammatory changes. 3. Frequency of coexistent HP infection increases with prednisone therapy duration. 4. Prednisone therapy of nephrotic children is indication for gastric and duodenal endoscopic examination.
Subject(s)
Duodenitis/drug therapy , Gastritis/drug therapy , Glucocorticoids/therapeutic use , Helicobacter Infections/drug therapy , Nephrotic Syndrome/complications , Prednisone/therapeutic use , Adolescent , Child , Child, Preschool , Disease Progression , Duodenitis/diagnosis , Duodenitis/etiology , Female , Gastric Mucosa/drug effects , Gastric Mucosa/pathology , Gastritis/diagnosis , Gastritis/etiology , Gastroscopy , Helicobacter Infections/diagnosis , Helicobacter Infections/etiology , Humans , MaleABSTRACT
Serum cholinesterase /ChE/ investigation in children with gastroduodenitis or peptic ulcer disease indicate its low activity, specially in children with peptic ulcer disease. These investigation can be index of parasympathetic tonus in digestive tract disease.
Subject(s)
Cholinesterases/blood , Duodenitis/enzymology , Gastritis/enzymology , Peptic Ulcer/enzymology , Adolescent , Child , Duodenitis/blood , Duodenitis/microbiology , Duodenum/innervation , Female , Gastritis/blood , Gastritis/microbiology , Helicobacter Infections/blood , Helicobacter Infections/enzymology , Helicobacter pylori , Humans , Male , Parasympathetic Nervous System/physiopathology , Peptic Ulcer/blood , Peptic Ulcer/microbiology , Stomach/innervationABSTRACT
The aim of our study was the endoscopic assessment of the oesophagus, stomach and duodenal mucosa in 42 allergic children aged 2-16 years with chronic abdominal complaints. We also attempted to assess Ketotifen efficacy in a selected group of 36 allergic children with different stages of inflammatory changes, including peptic ulcer. A control endoscopic examination was performed after 2, 4, 6, 8 weeks of Ketotifen treatment. A favourable effect of the application of Ketotifen was observed.
