[Initial experience with prophylactic Proteus vaccine immunization in an emergency clinic]. / Pervyi opyt profilakticheskoi immunizatsii proteinoi vaktsinoi v klinike skoroi pomoshchi.

As early as the first 24 hours since a severe isolated locomotor trauma the patients were immunized with Proteus vaccine. Such vaccination is shown to stimulate the production of serum specific antibodies, to reduce contamination of the wound with gram-negative agents, to shorten hospital stay and healing of the wound versus subjects vaccinated with staphylococcal anatoxin and nonimmunized patients.

[The effect of detoxifying hemosorptive hemosorption and physiotherapy on the immune status in acute exogenous poisoning]. / Vliianie detoksikatsionnoi gemosorbtsionnoi gemosorbtsii i fizioterapii na immunnyi status organizma pri ostrykh ékzogennykh otravleniiakh.

Similar changes in cellular and humoral immunity indicative of the onset of toxic immune depression have been revealed in 53 patients with acute poisoning with organophosphorus insecticides and psychotropic agents. The therapy employed hemosorption (HS), blood exposure to magnetic field and ultraviolet (UV) blood irradiation. Immunocorrection was the most effective in the combination of HS with UL blood irradiation. The technique accelerated lymphocyte differentiation and stimulated metabolic activity of neutrophils. Blood exposure to magnetic field had no considerable effect on the immunity indexes.

[The effect of an immune antibacterial plasma and a donor leukocyte mass on the immune system of patients with suppurative-septic processes]. / Vliianie immunnoi antibakterial'noi plazmy i donorskoi leikotsitnoi massy na immunnuiu sistemu bol'nykh s gnoino-septicheskimi protsessami.

The influence of immune antistaphylococcal, anti-Proteus and anti-Pseudomonas aeruginosa plasma and donor leukocyte mass on some humoral and cell-mediated immunity characteristics in patients with purulent and septic diseases has been studied. The study has shown that treatment with immune plasma leads to an increase in the amount of circulating T lymphocytes and in the concentration of IgA, IgM and IgG, to the activation of phagocytosis and to an increase in the titers of the corresponding antimicrobial antibodies simultaneously with a decrease in the content of bacterial antigens in the blood serum. Treatment with donor leukocyte mass has also been found to lead to an increase in the concentration of T lymphocytes and immunoglobulins, to enhance the functional activity of phagocytizing neutrophils and to promote the normalization of the content of leukocytes in the peripheral blood. The use of these preparations as stimulating agents in the treatment of patients having purulent septic diseases and, simultaneously, low cell-mediated immunity characteristics is recommended.

[Preventive properties of the blood sera from persons vaccinated with a Proteus vaccine made from soluble antigen complexes]. / Preventivnye svoistva syvorotok krovi liudei, vaktsinirovannykh proteinoi vaktsinoi iz rastvorimykh antigennykh kompleksov.

In experiments of the passive protection of mice the protective properties of sera obtained from humans before and after their immunization with Proteus vaccine used as a monopreparation or in combination with staphylococcal toxoid and/or pyoimmunogen were studied. When introduced in a single subcutaneous injection, Proteus vaccine prepared from soluble antigenic complexes ensured an increase in the protective properties of sera. The second injection of the vaccine essentially enhanced the protective potency of the sera of the immunized donors. The therapeutic injection of Proteus vaccine ensured the essential increase of the protective properties of the sera. This increase could be experimentally detected within at least 25-30 days from the beginning of immunization. The immunization of volunteers with Proteus vaccine in combination with pyoimmunogen and adsorbed staphylococcal toxoid ensured the maximum increase of the protective properties of their sera.