ABSTRACT
Cutaneous leiomyomas are relatively common benign smooth muscle tumors that may arise as solitary or multiple lesions. Rare forms with cytologic atypia, and features similar to symplastic leiomyomas of the uterus, have been described. We report a case of multiple cutaneous atypical leiomyomas occurring in a 43-year-old man with long history of lesions of the right lower leg and a family history of leiomyomatosis. Twenty of the lesions were excised due to pain and were examined histopathologically. All the lesions exhibited features described in atypical leiomyomas of the skin including increased cellularity, nuclear atypia and pleomorphism, and low mitotic activity. The biologic potential of cutaneous atypical leiomyomas is uncertain. Only a few case reports exist in the literature with the majority occurring as solitary lesions. Most of the reported atypical leiomyomas have behaved in a benign fashion. However, a rare account of transformation to leiomyosarcoma emphasizes the need for long-term follow up of these patients. Herein, we describe a case of multiple atypical cutaneous leiomyomas arising in the setting of familial leiomyomatosis.
Subject(s)
Leiomyomatosis/metabolism , Leiomyomatosis/pathology , Skin Neoplasms/metabolism , Skin Neoplasms/pathology , Adult , Diagnosis, Differential , Humans , MaleABSTRACT
The aroma of Fino sherry wines produced by industrial biological aging for 0, 1.5, 2.5, 4.5, and 6 years in the Montilla-Moriles region (southern Spain) was studied by gas chromatography-olfactometry. The aroma sensations detected by 3 trained sniffers were classified according to their odor descriptors into 8 odorant series (fruity, empyreumatic, chemical, fatty, balsamic, vegetable, floral, and spicy), describing the aroma profile of the studied wines. The results showed 47 detected odors in the unaged wines, 50 in the 1.5-years-old wines and 59, 61 and 69 in the wines aged 2.5, 4.5, and 6 years, respectively. According to the frequency of the perceived aromas, the fruity and empyreumatic series were the most characteristic odorant series. By exception of chemical, floral and balsamic series without changes during aging of the wines, the remainder series increased their participation during the aging, mainly the fruity, empyreumatic, and fatty series.
ABSTRACT
Se realizo un estudio doble ciego, aleatorizado, en 90 pacientes que iban a ser sometidos a anestesia general para cualquier procedimiento quirúrgico no urgente, para determinar la efectividad de la lidocaina intravenosa en la disminución de la respuesta hemodinámica a la laringoscopia y la intubación en por lo menos un 20 por ciento. Todos los pacientes eran ASA I o II, se les realizo una inducción, previa oxigenación, con fentanyl, rocuronio, tiopental y la droga del estudio (a un volumen igual), las dosis se estandarizaron. Se tomaron medidas de presión arterial no invasiva, frecuencia cardíaca y pulsoximetría a la llegada del paciente al entrar a la sala de cirugía, preintubación y al 1, 2, 3 minutos pos intubación. Se encontró una disminución de la PAM y no se encontró ninguna variación de la F.C con una P menor de 0.05 para ambas variables. A pesar de tener la presión arterial media y diatólica una p estadísticamente significativa (p< 0.02) pero con una diferencia con respecto a las cifras basales de menos del 20 por ciento lo que no representa un cambio clínicamente significativo
Subject(s)
Hemodynamics , Intubation, Intratracheal , Laryngoscopy , Lidocaine/administration & dosage , Lidocaine/metabolismABSTRACT
The effect of an acceleration assay, carried out with a periodic aeration and an increased surface/volume ratio, on various aroma compounds of "fino" Sherry wines aging under a veil of a pure culture of Saccharomyces cerevisiae race capensis G1 flor film yeast was studied. The results were subjected to multifactor analysis of variance, and the compounds simultaneously depending on acceleration conditions and aging time at p < 0.01 were subjected to principal component analysis. The first component, accounting for 86.14% of the overall variance, was mainly defined by acetaldehyde and its derivatives 1,1-diethoxyethane and acetoin. These compounds reached higher concentrations in accelerated aging wines in a shorter time than they did in control wines, and no browning problems were detected. Taking into account that these compounds can be used as indicators for biological aging of "fino" Sherry wines, the acceleration condition assayed can be applied to shorten the time of this process.
Subject(s)
Food Handling/methods , Odorants/analysis , Wine/analysis , Alcohols/analysis , Analysis of Variance , Esters/analysis , Fermentation , Food Microbiology , Saccharomyces cerevisiaeABSTRACT
Estudia restrospectivamente los ingresos, consultas y cirugías del Servicio de Trauma y Ortopedia, durante los meses de sep. a nov. de 1995. Se detectó una alta ocupación de la sala de trauma con tiempo de espera pre-operatorio prolongado, especialmente de los pacientes ingresados por emergencia. Además una subutilización del tiempo útil de quirófano por atrasos y suspensiones de las cirugías. Se presenta un estudio pormemorizado del flujo de pacientes, determinando los problemas, sus causas, haciendo finalmente la recomendación de posibles acciones que lleven a su colución...
Subject(s)
Child , Child , Health Services , Ecuador , Hospitals, Pediatric , PatientsABSTRACT
At least three independent groups of natriuretic hormones have been isolated over the past ten years. Two, atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), are proteins and the third is made up of digitalis-like substances (DLS). The present report concerns the isolation, substantial purification and biologic actions of an entirely different natriuretic hormone (NH) which appears to be steroidal in nature and an isomer of cortisone. The source of NH was uremic urine. Purification involved successive chromatographic steps including gel filtration and multiple HPLC runs through C-18 resins. A translucent crystal ultimately was obtained. The product was examined using mass spectroscopy with trimethylsilyl derivatization. Only one compound was identifiable. The characteristics of the molecule include: a molecular weight, 360.4; a molecular formula, C21H28O5; a steroidal nucleus; UV absorption at 220 and 290 nm; and intrinsic fluorescence. The onset of action occurs within minutes both in the rat and, as previously shown, in several in vitro systems including the frog skin, toad bladder, fibroblasts and renal tubular epithelial cells grown in culture and isolated perfused cortical collecting tubules. In contrast to DLS, NH has been previously shown not to cross react with digoxin antibodies. Moreover, when given to intact rats, it produces a profound natriuresis but little or no kaliuresis. In contrast to ANF and BNP the compound is active orally as well as intravenously. It is clearly different from cortisone, based both on its biologic and mass spectroscopic characteristics.
