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1.
Otolaryngol Head Neck Surg ; 125(3): 183-92, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11555752

ABSTRACT

OBJECTIVE: To determine the optimal stimulus paradigm, electrode orientation, and configuration of an implantable stimulator used to reanimate the posterior-cricoarytenoid (PCA) muscle in case of bilateral vocal fold paralysis (BVFP). STUDY DESIGN: Acute studies were conducted on 13 canines implanted with Itrel II systems with or without PCA innervation. PCA stimulus-response characteristics were obtained by measuring stimulated vocal fold displacement endoscopically. RESULTS: The denervated PCA was only 10% to 25% as responsive to stimulation as the innervated PCA. However, the response could be increased to 38% and 61% if the Itrel was modified to deliver 1 and 2 msec pulses, respectively. Stimuli delivered centrally to the muscle 5 mm from the median raphe improved performance. CONCLUSION AND SIGNIFICANCE: The optimal stimulus paradigm identified in this study (1 msec pulses delivered at 30 to 40 Hz and 2 to 8.5 mA) has been applied to implanted BVFP patients and improved outcome. Information regarding optimal electrode orientation could also be important to future clinical trials.


Subject(s)
Electric Stimulation Therapy/instrumentation , Prostheses and Implants , Vocal Cord Paralysis/therapy , Animals , Dogs , Electrodes , Electromyography , Laryngeal Muscles/physiopathology
2.
IEEE Trans Biomed Eng ; 48(8): 890-7, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11499526

ABSTRACT

The biocompatibility, integrity, positional stability, and potential use of hermetically sealed injectable wireless micromachined microstimulators were investigated for reanimation of the paralyzed larynx. The device, consisting of silicon and glass, has been tested and proven to be biocompatible with no evidence of pathological tissue reaction or rejection up to one-year implantation in the rat dorsum and canine larynx. By one month, each unit was encapsulated by a thin membrane, which thickened to form a fibrous layer of less than 500 microm at 6-12 months. The microstimulators demonstrated long-term in vivo durability: the hermetic seal of only one in ten devices was breached. Once implanted, migration of the device varied from 0 to 3 cm, depending upon the extent of surgical dissection. No discernable migration was noted when the tissue dissection was minimal. Studies utilizing a modified device equipped with electrodes indicated that migration was nominal with sufficient positional stability to ensure activation of target muscles for glottis opening. This study supported the feasibility of using a microstimulator for reanimation of paralyzed laryngeal muscles that open the airway during breathing. This innovative approach to treatment would alleviate the need for a tracheotomy or surgical resection of the vocal fold.


Subject(s)
Electric Stimulation/instrumentation , Larynx/physiopathology , Animals , Biocompatible Materials , Dogs , Glass , Microscopy, Electron, Scanning , Rats , Silicon
3.
Article in English | MEDLINE | ID: mdl-10729797

ABSTRACT

The present study examined the effects of functional neuromuscular stimulation (FNS) on posterior cricoarytenoid (PCA) muscle physiology and histochemistry. In 4 canines, 10 cm of the recurrent laryngeal nerve was resected. A patch electrode array was implanted for PCA stimulation. FNS was applied to 2 canines for a period of 4 weeks with 2 additional animals serving as nonstimulated controls. Results indicated that FNS increased PCA muscle contractility over the period of intervention but had no effect on contraction speed. FNS also protected the muscle from atrophy by preventing muscle weight loss and type 2 fiber deterioration. Finally, it rescued muscle fibers from ensuing fibrosis.


Subject(s)
Electric Stimulation , Laryngeal Muscles/physiology , Animals , Dogs , Electric Stimulation/methods , Laryngeal Muscles/innervation , Laryngeal Muscles/pathology , Muscle Contraction , Muscle Denervation , Recurrent Laryngeal Nerve/surgery
4.
Article in English | MEDLINE | ID: mdl-10729798

ABSTRACT

The present study examined the effects of functional neuromuscular stimulation (FNS) on reinnervation of the posterior cricoarytenoid (PCA) muscle. In 4 canines, the recurrent laryngeal nerve (RLN) was sectioned and anastomosed and a patch electrode array implanted for stimulation and recording at multiple PCA sites. Following implantation, FNS was applied to 2 canines for a period of 6 weeks. Two additional animals served as nonstimulated controls. In each animal, histomorphometric analysis of the RLN was used to assess the quality of nerve regeneration and the potential for muscle reconnection. The magnitude of reinnervation was monitored by electromyographic (EMG) potentials evoked by RLN stimulation. The appropriateness of reconnection was determined by the pattern of spontaneous EMG activity and recovery of vocal fold abduction. Results of this preliminary study indicated that FNS caused an overall repression of reinnervation. However, the repression preferentially inhibited reconnection by foreign nerve fibers, promoting selective reinnervation and preventing synkinesis.


Subject(s)
Electric Stimulation Therapy/methods , Laryngeal Muscles/innervation , Nerve Regeneration , Recurrent Laryngeal Nerve/physiology , Animals , Dogs , Electromyography , Laryngeal Muscles/pathology , Muscle Denervation , Recurrent Laryngeal Nerve/pathology , Recurrent Laryngeal Nerve/surgery
6.
Ann Otol Rhinol Laryngol ; 105(9): 689-93, 1996 Sep.
Article in English | MEDLINE | ID: mdl-8800054

ABSTRACT

This study represents the first attempt to electrically pace the paralyzed human larynx. The goal was to determine if electrical stimulation of the posterior cricoarytenoid muscle could produce functional abduction of the vocal fold in pace with inspiration. An external apparatus was used to sense inspiration and reanimate the unilaterally paralyzed larynx of a thyroplasty patient. Stimuli were delivered through a needle electrode to locate and pace the abductor muscle. The magnitude of electrically induced abduction was comparable to spontaneous movement on the normal side. The abduction was appropriately timed with inspiration: this finding demonstrated that this simple pacing system could effectively modulate stimulation with patient respiration.


Subject(s)
Electric Stimulation Therapy , Vocal Cord Paralysis/therapy , Adolescent , Electric Stimulation Therapy/instrumentation , Electric Stimulation Therapy/methods , Humans , Laryngeal Muscles/physiopathology , Male , Vocal Cord Paralysis/physiopathology
7.
Ann Otol Rhinol Laryngol ; 105(8): 592-601, 1996 Aug.
Article in English | MEDLINE | ID: mdl-8712628

ABSTRACT

Long-term follow-up of 3 to 7 years is reported on 18 patients who had undergone recurrent laryngeal nerve avulsion (RLNA) for the treatment of adductor spastic dysphonia (SD). Data on neural regrowth after previous recurrent laryngeal nerve section (RLNS) are presented in 2 of these 18 patients. We introduced RLNA as a modification of standard RLNS to prevent neural regrowth to the hemiparalyzed larynx and subsequent recurrence of SD. We have treated a total of 22 patients with RLNA, and now report a 3- to 7-year follow-up on 18 of these 22 patients. Resolution of symptoms was determined by routine follow-up assessment, perceptual voice analysis, and patient self-assessment. Sixteen of 18, or 89%, had no recurrence of spasms at 3 years after RLNA as determined at routine follow-up. Two of the 16 later developed spasms after medialization laryngoplasty for treatment of weak voice persistent after the avulsion. This yielded a total of 14 of 18, or 78%, who were unanimously judged by four speech pathologists to have no recurrence of SD at the longer follow-up period of 3 to 7 years. Two of these 4 patients were judged by all four analysts to have frequent, short spasms. The other 2 were judged by two of four analysts to have seldom, short spasms. Three of 18 patients presented with recurrent SD after previous RLNS. At the time of subsequent RLNA, each patient had evidence of neural regrowth at the distal nerve stump as demonstrated by intraoperative electromyography and histologic evaluation of the distal nerve stump. One remained free of SD following RLNA, 1 was free of spasms at 4 years after revision avulsion but developed spasms after medialization laryngoplasty, and the final patient developed spasms 3.75 years after revision RLNA. Medialization laryngoplasty with Silastic silicone rubber was performed in 6 of 18, with correction of postoperative breathiness in all 6, but with recurrence of spasm in 3. Spasms resolved in 1 of these with downsizing of the implant. We conclude that RLNA represents a useful treatment in the management of SD in patients not tolerant of botulinum toxin injections.


Subject(s)
Laryngeal Muscles/physiopathology , Laryngeal Nerves/physiopathology , Laryngeal Nerves/surgery , Muscle Spasticity/physiopathology , Voice Disorders/physiopathology , Adult , Aged , Electromyography , Female , Follow-Up Studies , Humans , Laryngeal Nerves/ultrastructure , Male , Middle Aged , Monitoring, Intraoperative , Nerve Regeneration , Silicone Elastomers , Voice Quality
8.
Otolaryngol Head Neck Surg ; 113(6): 760-5, 1995 Dec.
Article in English | MEDLINE | ID: mdl-7501389

ABSTRACT

The goal of this investigation was to test the hypothesis that tympanic membrane exposure to cold air is a cause of acute facial palsy. A series of acute invasive experiments and a series of chronic noninvasive experiments were conducted in both cats and dogs. In the acute studies, stimulation was applied intracranially to the facial nerve root through a stereotaxically placed microelectrode and recordings of compound action potentials obtained extracranially from the facial nerve. Nerve conduction was monitored continuously during the application of cold air to the tympanic membrane. Nerve conduction disturbances were observed in all animals tested (8), and reduction in compound action potential amplitude ranged from 33% to 96%. Histologic analysis of the intratemporal portion of the facial nerve was performed in the animal exhibiting the greatest block in conduction, representative of a near-total paralysis. Axon swelling, demyelinization, and degeneration (Bungner's bands) without inflammation were apparent along the entire tympanic membrane segment. Interstitial swelling of nerve endoneurium was also present at the second genu and vertical segment. In the chronic studies, animals were exposed to cold air and monitored daily for facial paralysis after recovery from anesthesia. None of the animals demonstrated any detectable behavioral facial paralysis.


Subject(s)
Cold Temperature , Facial Paralysis/etiology , Tympanic Membrane/physiology , Action Potentials , Acute Disease , Air , Animals , Axons/pathology , Cats , Demyelinating Diseases/pathology , Dogs , Facial Nerve/pathology , Facial Nerve/physiology , Facial Paralysis/pathology , Female , Male , Microelectrodes , Neural Conduction/physiology
9.
Otolaryngol Head Neck Surg ; 113(5): 517-29, 1995 Nov.
Article in English | MEDLINE | ID: mdl-7478641

ABSTRACT

The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long-term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new mode. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal fold mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.


Subject(s)
Awards and Prizes , Laryngeal Nerves/physiology , Larynx/transplantation , Nerve Regeneration , Animals , Electromyography , Evoked Potentials , Feasibility Studies , Glycogen/metabolism , Laryngeal Nerves/pathology , Larynx/pathology , Larynx/physiology , Male , Nerve Regeneration/physiology , Rats , Rats, Wistar , Vocal Cords/physiology
10.
Otolaryngol Head Neck Surg ; 111(5): 575-9, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7970795

ABSTRACT

Iatrogenic blindness resulting from conventional and endoscopic sinus surgery continues to be a major concern to the head and neck surgeon. A new electrophysiologic monitoring technique has been developed that can help avoid damage to the optic nerve and visual system. The approach involves monitoring the visual evoked potential with presentation of flash stimuli to the eyes. Thirty patients with chronic sinusitis underwent endoscopic sinus surgery with visual evoked potential monitoring. The procedures were carried out with patients under intravenous general anesthesia. Needle cortical electrodes were placed in the scalp. A modified light-emitting diode array/goggle was positioned in front of the patient's closed eyes. A triggered flash of 2 Hz was delivered through the goggle to stimulate the patient's retina. Cortical responses were amplified and averaged for 100 trials. Amplitude and peak-latency changes were monitored to alert the surgeon to any change in the visual response during the surgical dissection. Although no changes in response were noted during dissection, cold-water irrigation and reflected telescopic light could produce variations in the recorded responses, as will be discussed. Visual evoked potential monitoring may prevent a surgeon from continuing a bilateral procedure when there is indication of iatrogenic visual loss from dissection on the first side. Visual evoked potential also reassures the operator that no damage has occurred to the visual pathway at the conclusion of a case. Methods, case selection, operative technique, and documentation of monitoring will be discussed.


Subject(s)
Ethmoid Sinus/surgery , Evoked Potentials, Visual , Monitoring, Intraoperative/methods , Blindness/prevention & control , Endoscopy , Humans , Iatrogenic Disease/prevention & control
11.
Ann Otol Rhinol Laryngol ; 103(10): 780-8, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7944169

ABSTRACT

The effects of chronic posterior cricoarytenoid muscle denervation were assessed at 3 and 7 months in 26 animals following resection of 10 cm of recurrent laryngeal nerve with stump ligation. The physiology of denervation was characterized by a decrease in contraction strength and an increase in contraction time. The reduction in contraction strength reflected the loss in muscle weight and atrophic changes in fiber density and diameter. A change in muscle composition occurred because of the increased susceptibility of fast-twitch (type 2) fibers to degeneration. However, the compositional change alone could not account for the slowing of muscle contraction. Muscle fibrosis was negligible at 3 months, but encompassed one third of the fiber population by 7 months. In view of the irreversible nature of fibrosis, this study suggested that clinical intervention to rescue denervated posterior cricoarytenoid muscle fibers should be delayed no longer than 7 months to improve the chances for full recovery.


Subject(s)
Laryngeal Muscles/physiopathology , Muscle Denervation , Muscular Atrophy/physiopathology , Animals , Dogs , Laryngeal Muscles/chemistry , Laryngeal Muscles/innervation , Muscle Contraction/physiology , Muscle Fibers, Skeletal
12.
Ann Otol Rhinol Laryngol ; 103(9): 705-12, 1994 Sep.
Article in English | MEDLINE | ID: mdl-8085731

ABSTRACT

Functional electrical stimulation (FES) of the posterior cricoarytenoid (PCA) muscle to produce vocal fold abduction offers an alternative approach to current surgical therapies for bilateral vocal fold paralysis. The purpose of this study was to characterize the application of FES to chronically denervated PCA muscles. Specific goals were to develop a stimulus delivery system for the PCA muscle, determine a practical means of implantation, and identify stimulus parameters effective in activating chronically denervated muscle. Seventeen dogs were implanted with planar electrode arrays 3 months after unilateral recurrent laryngeal nerve resection. A nail-bed electrode array allowed discrete activation of the PCA muscle and gave the greatest abductions, with minimal charge dissipation. Muscle mapping revealed hot-spot regions on the PCA muscle surface, in which stimulation produced maximum abduction. A conservative stimulus paradigm effective in activating chronically denervated muscle was a 1-second pulse train of 2-millisecond-duration pulses, delivered at a tetanizing frequency of 30 Hz and an amplitude of 4 to 14 mA.


Subject(s)
Electric Stimulation Therapy/methods , Laryngeal Muscles/innervation , Vocal Cord Paralysis/therapy , Animals , Dogs , Electric Stimulation Therapy/instrumentation , Electrodes, Implanted , Equipment Design , Laryngeal Muscles/physiology , Muscle Denervation
13.
Laryngoscope ; 104(4): 420-5, 1994 Apr.
Article in English | MEDLINE | ID: mdl-8164480

ABSTRACT

Investigation of the effects of various factors on nerve regeneration has been compromised by the lack of an accurate and objective technique which can monitor dynamic changes in the status of nerve-muscle innervation over the entire course of regeneration. The approach of evoked electromyography (EEMG) was adopted to obtain temporal and quantitative data during nerve regeneration. Initially, transcutaneous nerve stimulation and percutaneous muscle recording was performed, but the approach was abandoned because of the high interest variability (20% average deviation) and requirement for anesthesia during testing. A new approach using chronically implanted stimulation and recording electrodes was adopted in an attempt to circumvent these problems. Initial acute studies performed in the hindlimb of the anesthetized rat identified stable EEMG recording sites with sciatic nerve stimulation. In a second study conducted in chronically implanted unanesthetized unrestrained animals, EEMG recording from these sites demonstrated remarkable stability with an average interest variability of only 5%. Preliminary results have been obtained with this technique in monitoring the progression of hindlimb reinnervation following crush and transection nerve injuries.


Subject(s)
Electrodes, Implanted , Electromyography , Sciatic Nerve/physiopathology , Animals , Evoked Potentials/physiology , Hindlimb/innervation , Models, Biological , Nerve Regeneration/physiology , Neuromuscular Junction/physiopathology , Rats , Sciatic Nerve/injuries , Time Factors , Transcutaneous Electric Nerve Stimulation
14.
Otolaryngol Head Neck Surg ; 106(4): 345-50, 1992 Apr.
Article in English | MEDLINE | ID: mdl-1565483

ABSTRACT

Suture repair of a severed peripheral nerve is cumbersome, presents a focus for infection and neuroma formation, and does not always produce adequate stump alignment. An alternative form of repair is laser nerve welding, which is attractive because it does not introduce foreign material into the anastomotic site, it forms a circumferential seal, and it can be performed in difficult-to-reach areas. Laser repair has not been widely accepted both because the effect of laser irradiation on intact nerves is not well documented, and the anastomotic strength of the weld has been inferior to suture repair. In the first part of the present study, rat sciatic nerves were exposed and irradiated with increasing intensities from a Sharplan CO2 and KTP laser to document nerve damage as recorded by decreases in the peak compound action potential. A new technique of laser repair (S-Q weld) was then developed that involved harvesting subcutaneous tissue from the adjacent dermis, wrapping it around the two opposed nerve stumps, and lasering it to the epineurium to effect a weld. The strength of the S-Q weld (6.1 grams) was considerably greater than that produced by laser welding alone. The third phase of the study compared regeneration at 2 months in severed rat sciatic nerves repaired by either microsuture or S-Q weld. Analysis of the compound action potential values indicated that the number of regenerating fibers after laser repair was greater than that after suture repair, although a significant difference could not be demonstrated.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Laser Therapy/methods , Peripheral Nerves/surgery , Action Potentials , Anastomosis, Surgical/methods , Animals , Rats , Rats, Inbred Strains , Sciatic Nerve/physiology , Sciatic Nerve/surgery , Sutures , Tensile Strength
15.
Ann Otol Rhinol Laryngol ; 100(1): 10-4, 1991 Jan.
Article in English | MEDLINE | ID: mdl-1985522

ABSTRACT

Treatment of spastic dysphonia by recurrent laryngeal nerve section has resulted in reproducibly good results in the early postoperative period in most patients. However, critical long-term follow-up has shown a high recurrence rate of adductor spasms by the third year after initial nerve section. A patient who developed recurring adductor spasms 1 year after nerve section was reexplored, with identification of neural regrowth into the distal segment of the recurrent laryngeal nerve. The technique of neural avulsion removing the distal nerve up to its insertion into the laryngeal muscles is described. Neural regrowth, which is just one of the possible mechanisms for recurrence of spastic dysphonia, should be prevented by this surgical modification. Twelve patients who have undergone neural avulsion primarily for spastic dysphonia are being followed up without recurrence of symptoms thus far. Although these results appear promising, this short follow-up that averages 1.5 years must be extended to firmly support these concepts.


Subject(s)
Recurrent Laryngeal Nerve/surgery , Voice Disorders/surgery , Female , Humans , Methods , Middle Aged , Nerve Regeneration , Recurrence , Recurrent Laryngeal Nerve/physiopathology , Voice Disorders/physiopathology
16.
Laryngoscope ; 100(12): 1264-9, 1990 Dec.
Article in English | MEDLINE | ID: mdl-2243515

ABSTRACT

Inflammation of the facial nerve in Bell's palsy can be demonstrated on gadolinium-enhanced magnetic resonance imaging. We have studied a series of 17 Bell's palsy patients with gadolinium-enhanced magnetic resonance imaging, and the purpose of this paper is to report our findings and discuss their significance. Most acute Bell's palsy cases demonstrate facial nerve enhancement, usually in the distal internal auditory canal and labyrinthine/geniculate segments. Other segments demonstrate enhancement less often. Gadolinium enhancement occurs regardless of the severity of the paralysis and can persist after clinical improvement of the paralysis. The findings of this study corroborate other evidence that the segments of the facial nerve most often involved in Bell's palsy are the only segments that are most often enhanced with gadolinium-enhanced magnetic resonance imaging. The role of gadolinium-enhanced magnetic resonance imaging in the management of Bell's palsy patients is discussed.


Subject(s)
Facial Paralysis/diagnosis , Magnetic Resonance Imaging , Organometallic Compounds , Pentetic Acid , Acute Disease , Adult , Aged , Electrodiagnosis , Facial Nerve/pathology , Facial Nerve/physiopathology , Facial Paralysis/pathology , Facial Paralysis/physiopathology , Female , Gadolinium DTPA , Humans , Male , Middle Aged , Prospective Studies
17.
Otolaryngol Head Neck Surg ; 99(6): 584-9, 1988 Dec.
Article in English | MEDLINE | ID: mdl-3148121

ABSTRACT

Antidromic facial nerve action potentials have been recorded noninvasively from the tympanic membrane (TM) of patients with Bell's palsy. A standardized approach has been developed in normal subjects that involves differential recording between the TM and adjacent canal wall. A metal annulus on the tip of an ear speculum served as the reference electrode. The speculum was held in place by an adjustable headband. A conductive sponge electrode inserted through the speculum served as the active TM electrode. In clinical trials, nerve potentials recorded from the paralyzed side were abnormal in all patients tested, indicating that nerve pathology could be monitored with this technique. Abnormalities were evident at the first test, within the first day of paralysis for some patients, and well in advance of any abnormality in the electroneuronography (ENoG) response. There appeared to be a relationship between specific waveform abnormalities (e.g., increased peak latency, waveform temporal dispersion, decreased area) and the tendency for a patient to recover from paralysis. These observations suggest that the technique described could serve as a means for early prognosis, at a stage in which nerve damage could still be effectively treated.


Subject(s)
Electrodiagnosis/instrumentation , Facial Nerve/physiopathology , Facial Paralysis/diagnosis , Tympanic Membrane/physiopathology , Action Potentials , Adolescent , Adult , Female , Humans , Male , Prognosis
18.
Laryngoscope ; 98(8 Pt 1): 891-3, 1988 Aug.
Article in English | MEDLINE | ID: mdl-3398668

ABSTRACT

Electroneurography (ENoG) is currently the most sophisticated and objective test available for assessing nerve degeneration in patients suffering from facial nerve paralysis. However, the test requires considerable experience before error due to intertest variability can be brought within reasonable limits. In a statistical study on normal participants, the error associated with two conventional recording techniques--optimized lead placement (OLP) and standardized lead placement (SLP)--was determined to be 17.8% and 20.7%, respectively. A significant increase in error was observed with the OLP approach (22.9%) if responses could not be monitored oscilloscopically, a common situation in patients with severe degeneration. In a final study, however, a previously unreported factor was found to significantly reduce test error: recording electrode size. In particular, unconventionally small recording electrodes (3 to 7 mm) produced as much as 4% less error when administering the technique.


Subject(s)
Electrodiagnosis/standards , Facial Paralysis/diagnosis , Nerve Degeneration , Data Interpretation, Statistical , Electrodes , Female , Humans , Male , Neural Conduction
19.
Laryngoscope ; 98(5): 568-72, 1988 May.
Article in English | MEDLINE | ID: mdl-3362022

ABSTRACT

A new electrodiagnostic technique has been developed which can be used to monitor facial nerve function. The technique has been termed "evoked accelerometry" (EAC) and is administered by a portable DC powered device. In performing a test, the device stimulates the facial nerve and then measures the evoked muscular response by a small accelerometer sensor affixed to the face with suction. The magnitude of the response is displayed as a digital readout on the device meter. The degree to which a reading is subnormal indicates the extent of nerve degeneration. In a study of normal participants the stimulus-response characteristics of the EAC technique were found to be similar to those of ENoG, indicating the clinical efficacy of the technique. However, evoked accelerometry was found to be more sensitive than ENoG (i.e., detectable response of 0.3% to 0.6% vs. 1.8% to 5.2%) and more accurate than ENoG (average error of 6.8% vs. 13.9% to 20.7%).


Subject(s)
Electrodiagnosis/methods , Facial Nerve/physiology , Biomechanical Phenomena , Electrodiagnosis/instrumentation , Evoked Potentials , Facial Nerve/physiopathology , Female , Humans , Male , Nerve Degeneration
20.
Otolaryngol Head Neck Surg ; 93(4): 474-81, 1985 Aug.
Article in English | MEDLINE | ID: mdl-3931021

ABSTRACT

A noninvasive technique has been developed for recording from the the facial nerve within the fallopian canal. Following transcutaneous stimulation of the nerve on the face, an antidromic nerve potential can be detected with electrodes placed on the eardrum and enhanced by the technique of averaging. In studies conducted on cats and normal human subjects it has been determined that the primary recording site of the nerve potential is along the tympanic segment of the nerve just distal to the geniculate ganglion. Disturbances in nerve conduction caused by an experimental lesion produced changes in the recorded nerve potential. Thus it seems likely that this technique could assess a developing lesion in a patient with idiopathic facial nerve paralysis. A more accurate and earlier prognosis could be obtained than with conventional peripheral nerve testing techniques, since the severity of the developing lesion itself could be assessed.


Subject(s)
Facial Nerve/physiopathology , Facial Paralysis/diagnosis , Neural Conduction , Animals , Cats , Ear, Middle , Electrodes , Evoked Potentials , Humans , Transcutaneous Electric Nerve Stimulation
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