[Blood serum immunoglobulins in small boys and adolescents with hypogonadism]. / Immunoglobuliny syvorotki krovi u mal'chikov i podrostkov, stradaiushchikh gipogonadizmom.

The immunoglobulin (Ig) concentration was studied in the blood serum of 31 boys with secondary hypogonadism. There was revealed a marked fall in the content of Ig of the A, M, and G classes, particularly of the M class, in all the patients before the treatment. After disappearance of the clinical hypogonadism signs and normalization of the blood testosterone level under the effect of chorionic gonadotropin therapy the plasma Ig concentration was found to be restored to the normal; the greatest relative elevation was revealed in case of IgM. Possible relations of testosterone with the immunocompetent organs and tissues are discussed.

[Immunoglobulin and lysozyme concentration in the serum of patients with Down's syndrome]. / Soderzhanie immunoglobulinov i lizotsima v syvorotke krovi bol'nykh bolezn'iu Dauna.

A study of the immunoglobulin level in the 3 main classes (IgG, IgM and IgA) and lysozymes in the blood serum of 73 patients with Down's disease (from 5 to 20 years of age) showed an increase of IgG in the younger age (up to 7 years) and older groups (over 7 years). The content of IgM was significantly lower in the younger group and did not differ from the control indices in the older group. The level of IgA corresponded to normal indices. The studies demonstrated a marked drop in the lysozyme content. The role of the abnormal system of humoral immunity and reactions of nonspecific defense in the formation of predisposition to the development of infectious diseases in this form of pathology is discussed.