ABSTRACT
3H cytidine autoradiographic labeling patterns have been categorized into those characteristic for neoplastic, preneoplastic, and normal cell types. Specific differences in the patterns of transcription (RNA synthesis) revealed that the histology of a particular lesion generally correlated with (1) the percentage of cells labeled with the isotope, (2) the number of grains per cell, and (3) their intracellular distribution. When these three criteria of labeling were applied to lesions of the oral mucosa, very interesting data were collected on cases of lichen planus. The benign histologic appearance of the oral lichen planus epithelium exhibited a preneoplastic-appearing autoradiogram, an observation which is of particular interest in view of the fact that a small number of patients with this disease develop intraoral squamous cell carcinoma.
Subject(s)
Lichen Planus/pathology , Mouth Diseases/pathology , Autoradiography , Cytidine/metabolism , Humans , Lichen Planus/metabolism , Mouth Diseases/metabolism , Mouth Neoplasms/pathology , Precancerous Conditions/pathology , RNA/metabolismSubject(s)
Chromatin/physiology , DNA Replication , Diptera/genetics , Gene Expression Regulation , Animals , Chromosomal Proteins, Non-Histone/physiology , Chromosomes/ultrastructure , DNA, Satellite , Genes , Heterochromatin/physiology , Hot Temperature , Models, Biological , Protein Biosynthesis , Replicon , Transcription, GeneticABSTRACT
The ultrastruct of hyaline bodies was examined. Their constant association with elements of squamous epithelium pointed to an epithelial component in their structure. Elements of red blood cells, blood vessels, and endothelium were not evi-ent in these hyaline bodies, thereby negating avascular origin. Due to ultrastrucural limitations, the exact composition of the structures could not be determined.
Subject(s)
Hyalin , Maxillary Diseases/pathology , Radicular Cyst/pathology , Adult , Cytoplasmic Granules/ultrastructure , Desmosomes/ultrastructure , Epithelium/pathology , Female , HumansABSTRACT
The authors report their third case of verruciform xanthoma confirmed by electron microscopy and frozen-section lipid stains. Studies of the blood in this case revealed normal levels of triglycerides, cholesterol, and glucose, just as in the previous two cases reported. An ultrastructural search for etiologic factors with the use of material from all three cases resulted in the hypothesis that this lesion is initiated within the epithelium. The authors propose that epithelial entrapment with degeneration and accumulation of lipid may be the logical sequence of early events leading to the formation of foam cells.