Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
1.
Clin Oral Investig ; 28(7): 357, 2024 Jun 06.
Article in English | MEDLINE | ID: mdl-38839609

ABSTRACT

OBJECTIVES: Risk factors for non-syndromic orofacial cleft (NSOFCs) include genetic profile and environmental exposure to medication and illnesses during pregnancy. We assessed the association between the COVID-19 vaccination and the incidence of NSOFC across five Middle Eastern countries. MATERIALS AND METHODS: This multi-country, hospital-based, case-control study included infants with NSOFCs whose first 3 intrauterine months coincided with the time when pregnant women were allowed to receive COVID-19 vaccination in the countries participating in the study. Newborns with NSOFCs were examined for cleft type and their parents were interviewed for maternal exposures and COVID-19 vaccination. Controls were newborns matched to cases in gender and setting. RESULTS: The study recruited 977 (348 children with NSOFCs and 629 controls). Maternal use of nicotine (Adjusted Odds Ratio (AOR): 2.437; P = 0.044) and family history of NSOFC (AOR: 11.059; P < 0.001) increased significantly the AOR of having a child with NSOFC. On the other hand, COVID-19 vaccine administration to pregnant mothers have significantly decreased the AOR of having a child with NSOFC (AOR: 0.337; P = 0.006). CONCLUSION: This study suggests that COVID-19 vaccination is not related to NSOFC and might protect against having a child affected with such a congenital anomaly. CLINICAL RELEVANCE: The finding of this study is important for healthcare providers for considering COVID-19 vaccination for pregnant woman. Clear communication and education about the potential risks and benefits would be crucial for informed decision-making. The study's results would directly impact pregnant individuals, as they would need accurate information to make informed decisions about their health and the health of their infants.


Subject(s)
COVID-19 Vaccines , Cleft Lip , Cleft Palate , Humans , Case-Control Studies , Female , Male , Cleft Lip/epidemiology , Pregnancy , Risk Factors , Infant, Newborn , Middle East , COVID-19/prevention & control , COVID-19/epidemiology , Incidence , SARS-CoV-2 , Adult
2.
BMC Oral Health ; 23(1): 246, 2023 04 28.
Article in English | MEDLINE | ID: mdl-37118740

ABSTRACT

BACKGROUND: The environmental etiology of non-syndromic orofacial clefts (NSOFCs) is still under research. The aim of this case-control study is to assess COVID-19 associated factors that may be related to the risk of NSOFC in five Arab countries. These factors include COVID-19 infection, COVID-19 symptoms, family member or friends infected with COVID-19, stress, smoking, socioeconomic status and fear of COVID-19. METHODS: The study took place in governmental hospitals in five Arab countries from November 2020 to November 2021. Controls are matched in the month of delivery and site of recruitment. A clinical examination was carried out using LASHAL classification. Maternal exposure to medication, illnesses, supplementation, COVID-19 infection during their pregestation and 1st trimester periods were evaluated using a validated questionnaire. Maternal exposure to stress was assessed using the Life Events scale, fear of covid-19 scale, family member or friend affected with covid-19 infection, pregnancy planning and threatened abortion. RESULTS: The study recruited 1135 infants (386 NSOFC and 749 controls). Living in urban areas, maternal exposure to medications 3-months pregestation, maternal exposure to any of the prenatal life events and maternal fear of COVID-19 significantly increased the risk of having a child with NSOFC. On the other hand, mothers exposed to supplementation 3-months pregestation, mothers suspected of having COVID-19 infection, family members or friends testing positive with COVID-19 significantly decreased the risk of having a child with NSOFC. CONCLUSIONS: This study suggests that NSOFC may be associated with maternal exposure to lifetime stress and COVID-19 fear in particular, with no direct effect of the COVID-19 infection itself. This highlights the importance of providing psychological support for expecting mothers during stressful events that affect populations such as the COVID-19 pandemic, in addition to the usual antenatal care.


Subject(s)
COVID-19 , Cleft Lip , Cleft Palate , Child , Female , Humans , Infant , Pregnancy , Case-Control Studies , Cleft Lip/epidemiology , Cleft Palate/epidemiology , COVID-19/epidemiology , Mothers , Pandemics , Risk Factors , Middle East/epidemiology , Egypt/epidemiology
3.
J Craniofac Surg ; 33(2): e171-e173, 2022.
Article in English | MEDLINE | ID: mdl-35385236

ABSTRACT

Cleft lip and/or palate are one of the most common birth defects around the world. This cross sectional study aimed to study characteristic of cleft lip and plate cases attended Khaula Hospital Cleft Center. METHODS: The data were collected from Plastic Surgery Department of Khaula Hospital Muscat, Oman, between years 2010 and 2019. Data was collected using a form that included demographic distribution of patients, gender, age, birth weight, region, age when first attended hospital, associated congenital anomalies and syndromes, type of delivery, mother consumption of Folic Acid, types of cleft lip/palate, and surgeries done. RESULTS: During 9 years period the total number of recorded patients having cleft Lip/Palate was 1899. 43.7% of cases had CLP, 36% had CP, 20.3% had complete fissuring of the lip. Sixty-eight percent of the children were between 0 and 3 months of age when they first attended Hospital. 6.2% of children had siblings with orofacial clefts. Congenital malformations associated with CL/P or syndromic cleft were seen in 31.1% of cases. 86.8% of children got operated at Hospital and most common types of surgeries were lip and palate repair. Twenty-three percent of patients had undergone orthodontic treatment, 49.3% of patients had speech therapy, 32.5% referred for ENT consultation, and 20.5% of patients got grommet inserted. CONCLUSION: Prevalence of CL/P in Oman is 2.6 in 1000 live births. Two main possible reasons contributing to the increase seen in this prevalence can be increase in the number of live births in Oman and parent's education toward cleft treatment that led more patients attending hospital for treatment.


Subject(s)
Cleft Lip , Cleft Palate , Child , Cleft Lip/epidemiology , Cleft Lip/surgery , Cleft Palate/epidemiology , Cleft Palate/surgery , Cross-Sectional Studies , Hospitals , Humans
5.
Oral Radiol ; 37(2): 256-266, 2021 Apr.
Article in English | MEDLINE | ID: mdl-32418067

ABSTRACT

INTRODUCTION: Accurately measuring tongue space is challenging, but this information can be useful to many dental specialties. This study was intended to estimate the reliability of using cone-beam computed tomography (CBCT) to measure tongue space, which includes tongue volume and the oral cavity air capacity. METHODS: For this preliminary study, CBCT images from ten participants (five females and five males, mean age of 29.8 ± 3.3 years) were available for evaluation. Each participant was radiographed two times (T0 and T1). The average time between T0 and T1 was 15.8 ± 3.7 days. CBCT scans were standardized to reduce variability. Three-dimensional landmarks were established to identify tongue space and 3D image analysis software (SimPlant® 17 Pro; Materialise Dental, Leuven, Belgium) was used to measure the volume circumscribed by the landmarks. Two investigators independently calculated airway, tongue dimensions, and total tongue space for CBCT image T0 twice (day 1 and day 14), and T1 once. Intraclass correlation coefficients (ICCs) were used to estimate intra-rater and inter-rater reliability. Bland-Altman charts were constructed to demonstrate agreement within and between raters. RESULTS: The intra-rater and inter-rater ICCs of the CBCT measurements at T0 were excellent (> 0.90). Measurements for T0 vs. T1 show good (0.75-0.90) intra-rater and excellent (> 0.90) inter-rater reliability. Bland-Altman charts show that 90-95% of the total measurements fall within the 95% limits of agreement for both intra- and inter-rater pairs CONCLUSIONS: The results of this preliminary study suggest that the landmarks chosen to measure the overall tongue space are reproducible and can be measured clearly using CBCT.


Subject(s)
Orthodontics , Spiral Cone-Beam Computed Tomography , Adult , Belgium , Female , Humans , Male , Reproducibility of Results , Tongue/diagnostic imaging
SELECTION OF CITATIONS
SEARCH DETAIL
...