ABSTRACT
BACKGROUND: Ghrelin is an appetite and weight physiologic controller. The question is whether there is a relation between ghrelin and protein-energy malnutrition (PEM). Our aim was to assess serum ghrelin in these patients and its relation to different patient variables. METHODS: A cross-sectional study was conducted on 30 PEM infants (12 marasmic=Ia, 10 kwashiorkor=Ib and 8 marasmic kwashiorkor=Ic) and 15 age and sex matched controls (II). Plasma ghrelin was measured in all subjects using radioimmunoassay with thorough medical history and clinical assessment. RESULTS: The mean serum ghrelin levels were significantly higher among the 3 patient subgroups than controls with no significant inter-subgroup differences. The presence of intestinal parasitic infestations or edema, type of milk feeding and gender had no significant effects on serum ghrelin levels. CONCLUSION: Serum ghrelin is elevated in PEM as an adapting consequence of the malnutrition rather than a primary event. Although this elevation may not be helpful to correct the growth failure because of deficient nutrients, it may prove to have a role in the catch up phenomenon after the recovery. Further research should be directed toward therapeutic trials of ghrelin in the recovery phase.
