[Diagnostic value of the luliberin test with patients with polycystic ovaries]. / Diagnosticheskaia tsennost' proby s liuliberinom u bol'nykh polikistozom iaichnikov.

Gonadotropic function was investigated and the diagnostic value of the test with luteinizing hormone releasing factor (LHRF) was assessed in patients with polycystic ovaries. For this purpose a 100 micrograms dose of LHRF was intravenously jet injected to 10 patients with nonspecific polycystic ovaries. Levels of luteinizing and follicle stimulating hormones (LH and FSH) were determined before the injection and 15, 30, 60, 90 or 120 minutes after it. Patients with nonspecific polycystic ovaries compared with those who had specific pattern of the disease or with normal women showed elevated basal LH levels which significantly increased in response to LHRF administration. In patients with specific form of the disease the FSH response to the injection was inhibited while LN basal levels as well as its response to LHRF were the same as in healthy women. In 13 out of 15 patients (3 out of 4 amenorrheic females among them) the preparation displayed its ovulatory affect after a single diagnostic dose. Desirability of LHRF use for a differential diagnosis of polycystic ovaries or for therapeutic stimulation of ovulation was suggested.

[Lactotropic and thyrotropic functions of the hypophysis in polycystic ovary syndrome]. / Laktotropnaia i tireotropnaia funktsii gipofiza pri polikistoze iaichnikov.

An increase in the prolactin basal level was detected in 8 out of 50 patients with ovarian polycystosis. A test with TRH and a simultaneous determination of the levels of prolactin, TTH, T3, T4 were used in 25 patients, of them a hyperergic reaction of prolactin to TRH was detected in 5. A correlation analysis of function of the thyroid was performed. Positive correlation between the levels of prolactin and TTH in patients with hyperprolactinemia and between a maximum increment in percentage to the initial level of TTH and prolactin in patients with a hyperergic reaction of prolactin to TRH was revealed. A conclusion was made of the common nature of disorder in the mechanisms of regulation of prolactin and thyroid function in patients with ovarian polycystosis.

[Inhibiting effect of dioxidine on corticosteroid secretion in an experiment]. / Ingibiruiushchee vliianie dioksidina na sekretsiiu kortikosteroidov v éksperimente.

The determination of corticosterone and aldosterone levels in the peripheral blood of rats and a cortisol level in the blood of guinea pigs by a radioimmunoassay following the administration of dioxydin (1,4-N-oxide 2 2,3-dioxymethylquinoxaline) has shown that it produces an inhibiting effect upon the secretion of corticosteroid hormones in animals with a diverse direction of their biosynthesis. There is a dose dependence of the effect detected. Substitution therapy with corticosteroids cuts short adrenal insufficiency caused by dioxydin.

[Various hormonal interrelations in idiopathic edema]. / Nekotorye gormonal'nye vzaimootnosheniia pri sindrome idiopaticheskikh otekov.

The content of aldosterone and renin activity were examined together with the determination of progesterone, estradiol, gonadotropins and prolactin in the blood of 39 women with idiopathic edemas and in 15 normal women in different phases of menstrual cycle. Women with idiopathic edemas showed a number of hormonal deviations: absolute and relative hyperaldosteronism, particularly demonstrable in the ortho-position, impairment of physiological stability between aldosterone levels in the luteic and folliculin phases; a decrease in progesterone level in the luteic phase; a decrease in the absolute amount of estrogens in the folliculin phase and relative hyperestrogeny in the luteic one; an increase in prolactin content in the early folliculin phase in a considerable number of patients (50%). It is assumed that deviations described might be involved in the formation of edemas.

[Gonadotropic regulation of androgen-producing ovarian tumors]. / O gonadotropnoi reguliatsii androgenprodutsiruiushchikh opukholei iaichnikov.

As a result of the study of the LH, FSH, prolactin and testosterone content in the blood of patients with androgen-producing ovarian tumors and LH-tumor tissue binding in vitro, it was detected that the gonadotropic hormone content may be low, normal and high. The testosterone level does not correlate with LH, FSH and prolactin concentration. LH-receptor binding is disturbed in the androgen-producing tumor tissue and hormone presence is not necessary to maintain androgen secretion by the tumor.

[Use of glucocorticoid preparations in congenital adrenocortical dysfunction]. / Primenenie gliukokortikoidnykh preparatov pri vrozhdennoi disfunktsii kory nadpochechnikov.

Circadian changes in the corticosteroid, testosterone, and ACTH content in the blood plasma were examined to monitor the suppressant effect of glucocorticoids on adrenocortical and hypophyseal functions during administering glucocorticoid drugs to patients with congenital adrenocortical dysfunction. The daily dose of glucocorticoids was given in two intakes according to the two schemes: scheme 1 included the drug intake in the morning and in the afternoon, scheme 2 in the morning and in the evening. The effect of glucocorticoid therapy on the pattern of the circadian rhythm and the absolute corticosteroid and testosterone content was shown to depend on the time of the drug intake. The treatment according to scheme 2 is preferable: the absolute testosterone content was reducing to normal during the whole day. Meanwhile the normal circadian rhythm of the adrenal cortex and hypophysis was preserved.

[Specificity of LH binding by interstitial tissues of polycystic ovaries in comparison with their androgenic activity]. / Spetsifichnost' sviazyvaniia liuteiniziruiushchego gormona mezhutochnoi tkan'iu polikistoznykh iaichnikov v sopostavlenii s ikh androgennoi aktivnost'iu.

125I-LH binding by interstitial tissues of 33 polycystic ovaries was studied comparatively to their androgenic activity. It was shown that the disorder of LH binding by the ovary interstitial tissue is peculiar to the polycystic ovaries in ovarian hyperandrogeny. Changes in 125 I-LH binding by the interstitial tissue and the ovary androgenic activity are closely correlated.

[Luteinizing hormone secretion in cryptorchism and anorchism]. / Sekretsiia liuteiniziruiushchego gormona u bol'nykh kriptorkhizmom i anorkhizmom.

The plasma LH content was studied in 22 patients aged 1 to 16 years, suffering from cryptorchidism and anorchism, by radioimmunoassay. The gonad androgenic function was evaluated according to the plasma testosterone level under conditions of the functional test with chorionic gonadotrophin. Considerable polymorphism in the gonad function change was found: in 45.4% of patients with cryptorchidism LH secretion was elevated, in 31.8% reduced, in 22.7% it did not differ from the age norm. In 56.2% of patients with anorchism, OH secretion was heightened, in 18.8% decreased, in 25 it did not deviate from the age norm. The LH level increase was recorded in prepuberal age and in anorchism it was pronounced to a greater degree. Correlation between LH and gonad function revealed under conditions of the test with chorionic gonadotrophin, was noted in cryptorchidism.

[Use of Soviet-made menotropin for the treatment of hypogonadotropic hypogonadism in women]. / Primenenie otechestvennogo preparata manopauznogo gonadotropina dlia lecheniia gipogonadotropnogo gipogonadizma u zhenshchin.

Investigation of the therapeutic efficacy of menopause gonadotropin (MPG), made in the USSR, in patients with hypogonadotropic hypogonadism demonstrated MPG to possess the FSH-activity. In a number of patients with hypogonadotropic hypogonadism MPG treatment led to the occurrence of the ovular menstrual cycle, confirmed both clinically and by hormonal studies. But sometimes MPG proved to be ineffective, this pointing to the necessity of individual choice of a drug dose and the number of therapeutic courses.

[Aldosterone and progesterone content and blood renin activity in women with idiopathic edema syndrome in various phases of menstrual cycle]. / Soderzhanie al'dosterone, progesterona i aktivnost' renina v krovi u zhenshchin s sindromom idiopaticheskikh otekov v razlichnye fazy menstrual'nogo tsikla.

Aldosterone and progesterone content and renin activity were studied by the radioimmunological method in women with the idiopathic edema syndrome and in healthy women in various phases of the menstrual cycle. The most significant differences were revealed in the luteinic phase of the cycle. A parallel elevation of the renin activity and of the aldosterone level against the background of a high progesterone level occurred in healthy women at this phase. Patients showed greater increase in the aldosterone level with the reduction of renin activity and a low progesteron level. Hyperaldosteronism was observed in patients with the idiopathic edema syndrome in all the phases of the cycle. It is suggested that an excessive elevation of the aldosterone level and a decrease in the progesterone level in the luteinic phase of the cycle could served as one of the pathogenetic mechanisms of the edema syndrome formation.

[Androgenic function of the testes in children and adolescents with cryptorchism]. / Androgennaia funktsiia iaichek pri kriptorkhizme u detei i podrostkov.

Androgenic function of the testes was studied in children and adolescents suffering from cryptorchism. Information on this problem is scant and controversial. The most sensitive radioimmunological methods of testosterone determination and functional test with chorionic gonadotropin were used in this work. Disturbances in adrogenic function are present in a number of cases as soon as the first years of life. These disturbances are intensified with the advance of age, and become particularly pronounced in bilateral and abdominal cryptorchism.

[Gonadotropic regulation of ovarian function in patients with polycystic ovaries]. / Izuchenie gonadotropnoi reguliatsii ovarial'noi funktsii u bol'nykh s polikistozom iaichnikov.

The authors studied the LH-125I binding by the interstitial tissue of 12 polycystic ovaries obtained after wedge resection of the ovaries in 6 patients. Prior to the operation the patients were differentiated by the LH, FSH, prolactin, and testosterone level. Disturbances of LH125I binding were revealed in the interstitial tissue of polycystic ovaries. The peripheral blood LH level did not correlate with disturbances of the LH125I binding.