ABSTRACT
Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoclonic epilepsy to 3 antiepileptic's drugs characterized by 4 myoclonic and 20 absence seizures monthly. She received tACS at 1 mA at 3 Hz pulse train during 60 min over Fp1-Fp2 (10-20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device® (Natus Medical Incorporated, Middleton, WI, USA). At the 1-month follow-up, she reported a 75% increase in seizures frequency (only myoclonic and tonic-clonic events) and developed a 24-h myoclonic status epilepticus that resolved with oral clonazepam and intravenous valproate. At the 2-month follow-up, the patient reported a 15-day seizure-free period.
ABSTRACT
OBJECTIVE: To compare the Robert Jones bandage with the "U" splint in edema control of ankle fractures. MATERIAL AND METHODS: A prospective, longitudinal study, open, comparative and randomized made in 32 male patients (72%) and 16 female patients (28%), the average age was 36.9 years. Patients with an ankle fracture within 12 hours of evolution were registered. Both ankles previous to immobilization were measured, dividing the patients in 2 groups. Group 1 were treated with Robert Jones Bandage, and group 2 with "U" splint. The pain previous to immobilization was registered using an analogous visual scale. Twenty-four hours later the circumference and the pain was measured again. RESULTS: Group 1 displayed less edema, mean 17.69 mm, in comparison with group 2, of 8.33 mm (p < or = 0.36). Pain previous to immobilization in group 1 was a mean of 7 and in group 2 of 5.5 (p < or = 0.3); 24 hours later, a mean of 2 in both (p < or = 0.8). CONCLUSIONS: There were no significant differences between both immobilization methods.
Subject(s)
Ankle Injuries/therapy , Bandages , Fracture Fixation/methods , Splints , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Prospective StudiesABSTRACT
Tres de los más grandes problemas que afrontan el médico ante el cáncer broncogénico son, en primer lugar, su diagnóstico temprano, secundariamente el tratamiento específico y, finalmente, medios adecuados para determinar la evolutividad del padecimiento. Por ello, muy probablemente los marcadores tumorales, en un futuro ocupen un lugar preponderante para mejorar la sobrevida, calidad de la misam y el tratamiento adecuado en los pacientes portadores de neoplasias pulmonares. El presente trabajo, está avalado por la experiencia de nuestro Departamento con dos marcadores tumorales: antígeno carcinoembrionario y hormona gonadotropina criónica en 20 pacientes con otras patologías pulmonares. Nuestros resultados demostraron significación estadística, aunque no en todos los rubros estudiados, de lo que se concluye que es necesario un mayor número de investigaciones en cuanto a cáncer pulmonar y marcadores tumorales re refiere; tomando en cuenta que en la actualidad se conocen más de 20 marcadores diversos, sin que ninguno reúne un alto grado de confiabilidad
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Carcinoembryonic Antigen , Carcinoma, Bronchogenic/diagnosis , Chorionic Gonadotropin , Biomarkers, Tumor , Carcinoembryonic Antigen/administration & dosage , Carcinoma, Bronchogenic/epidemiology , Carcinoma, Bronchogenic/therapy , Chorionic Gonadotropin/administration & dosageABSTRACT
Los marcadores tumorales, hasta el momento, son una de las mayores esperanzas para un diagnóstico temprano y un seguimiento terapéutico adecuado, sin embargo, los investigadores no han encontrado aún el marcador ideal con alta sensibilidad y especificidad. La presente monografía, presenta el estado actual de estas substancias en relación al cáncer broncogénico.
