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Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia.
Ramakrishnan, Girija; Wright, Marcia; Alam, Masud; Naylor, Caitlin; Kabir, Mamun; Zerin, Ayesha; Ferdous, Tahsin; Pedersen, Karl; Hennig, Branwen J; Donowitz, Jeffrey R; Wegmuller, Rita; Haque, Rashidul; Petri, William A; Herbein, Joel; Gilchrist, Carol A.
Diagn Microbiol Infect Dis ; 87(3): 272-274, 2017 Mar.
Article in English | MEDLINE | ID: mdl-27916543

ABSTRACT

We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.


Subject(s)
Antibodies, Bacterial/blood , Peptide Fragments/immunology , Recombinant Proteins/immunology , Tetanus Toxin/immunology , Tetanus Toxoid/immunology , Tetanus/immunology , Adult , Bangladesh , Child , Gambia , Humans , Male , Peptide Fragments/genetics , Recombinant Proteins/genetics , Sensitivity and Specificity , Tetanus Toxin/genetics , Vaccination
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