1.
Med Mal Infect
; 41(4): 206-8, 2011 Apr.
Article
in French
| MEDLINE
| ID: mdl-21195566
ABSTRACT
Inherited complement deficiency is a rare disease. It predisposes to autoimmune diseases, glomerulonephritis, angioedema, and meningococcal meningitis. A prospective study was conducted over five years. The goal was to evaluate the prevalence of deficiency in Tunisian patients presenting with community acquired purulent meningitis and identify the type of deficiency. We enrolled 122 patients, 15 of whom presented with a complement deficiency (12.3%). This prevalence was higher than the one observed in the global Tunisian population and in reported international data. The mean age of deficient patients (13 men and two women) was 24.7 years.
Subject(s)
Complement System Proteins/deficiency , Immunologic Deficiency Syndromes/genetics , Meningitis, Bacterial/complications , Adolescent , Adult , Aged , Aged, 80 and over , Community-Acquired Infections/blood , Community-Acquired Infections/complications , Community-Acquired Infections/immunology , Complement System Proteins/analysis , Complement System Proteins/genetics , Disease Susceptibility , Female , Humans , Immunocompromised Host , Immunologic Deficiency Syndromes/complications , Immunologic Deficiency Syndromes/epidemiology , Male , Meningitis, Bacterial/blood , Meningitis, Bacterial/immunology , Meningoencephalitis/blood , Meningoencephalitis/complications , Meningoencephalitis/epidemiology , Meningoencephalitis/immunology , Middle Aged , Prevalence , Prospective Studies , Tunisia/epidemiology , Young Adult
2.
Ann Rheum Dis
; 68(9): 1508-9, 2009 Sep.
Article
in English
| MEDLINE
| ID: mdl-19674987