ABSTRACT
Collagenous and lymphocytic colitis are two inflammatory conditions of the colon that are often collectively referred to as microscopic colitis. The present report describes what is believed to be the third published case of familial microscopic colitis. A 55-year-old woman who suffered from chronic diarrhea was diagnosed with lymphocytic colitis on colonic biopsy. Subsequently, her 36-year-old daughter was diagnosed with collagenous colitis. The familial occurrence of these diseases may support an immunological hypothesis for their etiology. In addition, it supports the assumption that collagenous and lymphocytic colitis are two manifestations of the same disease process rather than two completely separate entities. The familial tendency of this disease may make a case for early colonoscopy and biopsy in relatives of patients diagnosed with microscopic colitis if they present with suggestive symptoms.
Subject(s)
Colitis/genetics , Colitis/pathology , Abdominal Pain/etiology , Adult , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Biopsy , Colitis/complications , Colitis/drug therapy , Colitis/immunology , Colonoscopy , Constipation/etiology , Diarrhea/etiology , Female , Genetic Predisposition to Disease/genetics , Humans , Mesalamine/therapeutic use , Middle Aged , PedigreeABSTRACT
Microcystic meningioma is an unusual variant, which has recently been proposed for inclusion in the WHO Classification of Central Nervous System Tumors. Its unique structure produces findings that may be confusing to radiologist and pathologist alike. A case is reported and the English language literature reviewed.
Subject(s)
Meningeal Neoplasms/diagnostic imaging , Meningioma/diagnostic imaging , Aged , Cysts/diagnostic imaging , Cysts/pathology , Humans , Male , Meningeal Neoplasms/pathology , Meningioma/pathology , RadiographyABSTRACT
We report a rare primary adrenal leiomyosarcoma in a 30-year-old, human immunodeficiency virus--positive man. This is, we believe, the third documented case in the English literature of this tumor in this site, and the first to be reported in an adult male with acquired immunodeficiency syndrome. The smooth muscle origin of this tumor was apparent by routine microscopy and confirmed by positive immunostaining for smooth muscle actin. The patient is presently well and shows no evidence of recurrence 20 months after surgery. The present findings are discussed with reference to the reported rising incidence of smooth muscle tumors in human immunodeficiency virus--infected patients and the associated etiologic role of Epstein-Barr virus in the pathogenesis of these tumors.
