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Transplant Proc ; 42(2): 454-6, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20304163

ABSTRACT

To study if the treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rabbits with ADO (15 mg x kg(-1), intravenously) or saline solution (SS) to I (60 minutes) before occlusion of superior mesenteric artery and/or R (120 min). After I or I/R, isolated jejunal segments (2 cm) were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in I + ADO, but reduced in I + SS, I/R + SS, and I/R + ADO groups. We concluded that the jejunal enteric nerves were damaged in I + SS, I/R + SS, and I/R + ADO, but not in I + ADO group. These results suggested that ADO attenuated intestinal dysfunction due to I, but not to R.


Subject(s)
Adenosine/pharmacology , Intestines/blood supply , Reperfusion Injury/drug therapy , Animals , Blood Circulation , Electric Stimulation , Femoral Vein/drug effects , Femoral Vein/physiology , Jejunum/blood supply , Jejunum/drug effects , Jejunum/physiology , Male , Mesenteric Artery, Superior/physiology , Muscle Contraction/drug effects , Muscle Contraction/physiology , Potassium Chloride/pharmacology , Purinergic P1 Receptor Agonists , Rabbits , Sodium Chloride/pharmacology
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