Catalytic performance of modified carbon black on methane decomposition for hydrogen production.

Carbon-based catalysts catalyze methane decomposition to produce hydrogen is a very attractive technical route. Carbon black in carbon-based catalysts has the advantages of high catalytic activity, good stability and better tolerance to toxic impurities such as sulphur in the feedstock, which has become a hot topic of research for many scientists. In this work, the effect of heat treatment on the structural and surface properties of carbon blacks and their catalytic performance in hydrogen production from methane decomposition was investigated. A commercial carbon blacks N110 was selected to heat treatment with nitrogen or carbon dioxide atmosphere at 850 °C, respectively. The Raman spectrums indicated that the graphitization degree of modified carbon under two atmospheres were promoted with the treatment time increasing. BET results revealed that the specific surface area of the carbon black treated under carbon dioxide increased, while the specific surface area was unchanged for that of the carbon black treated under nitrogen. The catalytic test of the two modified carbon blacks for methane decomposition exhibited the almost same activity, which meant that the graphitization degree of carbon black is the key factor for methane decomposition rather than the specific surface area. It was suggested that highly graphitized carbon black could be used as the potential catalysts for hydrogen production from methane decomposition.

Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism.

Epitranscriptome (RNA modification) plays a vital role in a variety of biological events. N6-methyladenosine (m6A) modification is the most prevalent mRNA modification in eukaryotic cells. Dynamic and reversible m6A modification affects the plasticity of epitranscriptome, which plays an essential role in lipid metabolism. In this review, we comprehensively delineated the role and mechanism of m6A modification in the regulation of lipid metabolism in adipose tissue and liver, and summarized phytochemicals that improve lipid metabolism disturbance by targeting m6A regulator, providing potential lead candidates for drug therapeutics. Moreover, we discussed the main challenges and possible future directions in this field.

Ginseng and ginsenosides: Therapeutic potential for sarcopenia.

Sarcopenia is a progressive syndrome that results in a decline in skeletal muscle mass and strength. This affects patients' quality of life and increases the risk of falls and fractures, particularly among the elderly. With the aging of the population and the increasing number of patients with modern chronic diseases, the prevalence and complications of sarcopenia have increased, involving Akt-mediated signaling pathways, mitochondrial activity, satellite cell differentiation, inflammation and so on. Ginseng is a traditional herb medicine with extremely high medicinal value and possesses multiple pharmacological effects. This article summarizes such impacts of ginseng extracts and active ingredients on sarcopenia, and analyzes their related signaling pathways, so as to provide a reference for future research regarding the application of ginseng and ginsenosides as a potential therapy for sarcopenia.

Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.

Obesity is a chronic metabolic disease caused by an imbalance between energy intake and expenditure during a long period and is characterized by adipose tissue disfunction and hepatic steatosis. The aim of this study was to investigate the effect of 4-methylesculetin (4-ME), a coumarin derivative, upon adipose microenvironment and hepatic steatosis in mice induced by a high-fat diet (HFD), and to explore potential mechanisms of its beneficial effect on metabolic disorders. HFD-fed mice displayed visceral obesity, insulin resistance, and hepatic lipid accumulation, which was remarkably ameliorated by 4-ME treatment. Meanwhile, 4-ME ameliorated adipocyte hypertrophy, macrophage infiltration, hypoxia, and fibrosis in epididymal adipose tissue, thus improving the adipose tissue microenvironment. Furthermore, 4-ME reversed the increase in CD36, PPAR-γ, SREBP-1, and FASN, and the decrease in CPT-1A, PPAR-α, and Nrf2 translocation into the nucleus in livers of HFD mice and in FFA-incubated hepatocytes. Moreover, the beneficial effects of 4-ME upon lipid deposition and the expression of proteins related to lipid metabolism in FFA-induced LO2 cells were abolished by ML385, a specific Nrf2 inhibitor, indicating that Nrf2 is necessary for 4-ME to reduce hepatic lipid deposition. These findings suggested that 4-ME might be a potential lead compound candidate for preventing obesity and MAFLD.