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J Infect Dev Ctries ; 18(5): 751-760, 2024 May 30.
Article in English | MEDLINE | ID: mdl-38865399

ABSTRACT

INTRODUCTION: Although nontuberculous mycobacterial (NTM) infection is a common cause of pulmonary disease worldwide, few studies have focused on epidemiological and therapeutic factors related to NTM cases in Anhui Province, China. This retrospective study aimed to identify aetiological and clinical factors, and treatment outcomes of patients with NTM pulmonary disease (NTMPD) in Anhui. METHODOLOGY: Retrospective clinical data obtained from medical records of NTMPD patients seeking care at Anhui Chest Hospital from July 2019 to June 2022 were analyzed. Treatment outcomes were compared between two patient groups: one receiving a standardised NTM treatment regimen and the other receiving precision treatment regimens. RESULTS: Genotypic analysis of 672 clinical NTMPD-associated isolates revealed that most were Mycobacterium intracellulare, while drug-susceptibility test results demonstrated diverse antibiotic resistance profiles for these isolates. Cough was the most common symptom for 101 NTMPD patients. After patients of both groups received treatment, symptoms improved, sputum culture conversion was observed for some patients, imaging findings stabilised; however, no statistically significant intergroup differences in treatment outcomes were found. CONCLUSIONS: In this study, M. intracellulare was the predominant NTM species identified in isolates obtained from NTMPD patients. Drug resistance profiles of our patient isolates were complex, highlighting the need for administration of timely, more effective, standardised treatments for patients with NTMPD in Anhui Province, China.


Subject(s)
Anti-Bacterial Agents , Mycobacterium Infections, Nontuberculous , Humans , China/epidemiology , Retrospective Studies , Mycobacterium Infections, Nontuberculous/microbiology , Mycobacterium Infections, Nontuberculous/drug therapy , Mycobacterium Infections, Nontuberculous/epidemiology , Male , Female , Middle Aged , Aged , Anti-Bacterial Agents/therapeutic use , Treatment Outcome , Nontuberculous Mycobacteria/isolation & purification , Nontuberculous Mycobacteria/drug effects , Nontuberculous Mycobacteria/genetics , Adult , Microbial Sensitivity Tests , Lung Diseases/microbiology , Lung Diseases/drug therapy , Lung Diseases/epidemiology , Sputum/microbiology
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