ABSTRACT
We propose a new method to estimate the change of the effective reproduction number with time, due to either disease control measures or seasonally varying transmission rate. We validate our method using a simulated epidemic curve and show that our method can effectively estimate both sudden changes and gradual changes in the reproduction number. We apply our method to the COVID-19 case counts in British Columbia, Canada in 2020, and we show that strengthening control measures had a significant effect on the reproduction number, while relaxations in May (business reopening) and September (school reopening) had significantly increased the reproduction number from around 1 to around 1.7 at its peak value. Our method can be applied to other infectious diseases, such as pandemics and seasonal influenza.
