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Molecules ; 23(12)2018 Dec 14.
Article in English | MEDLINE | ID: mdl-30558133

ABSTRACT

1,1,1,3,3,3-Hexafluoropropan-2-ol (HFIP) was found to be effective for the Bischler indole synthesis under microwave irradiation in the absence of a metal catalyst. Under the catalysis of HFIP, a wide range of α-amino arylacetones were successfully transformed into indole derivatives with moderate to good yields.


Subject(s)
Indoles/chemistry , Microwaves , Catalysis , Cyclization , Molecular Structure
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