1.
Org Biomol Chem
; 15(26): 5571-5578, 2017 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-28639676
ABSTRACT
An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2 for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF2H group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.
