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J Nat Prod ; 84(2): 247-258, 2021 02 26.
Article in English | MEDLINE | ID: mdl-33533247

ABSTRACT

Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 µM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 µM.


Subject(s)
Anti-Inflammatory Agents/pharmacology , Antineoplastic Agents, Phytogenic/pharmacology , Asteraceae/chemistry , Lactones/pharmacology , Sesquiterpenes/pharmacology , Animals , Anti-Inflammatory Agents/isolation & purification , Antineoplastic Agents, Phytogenic/isolation & purification , China , HCT116 Cells , HeLa Cells , Hep G2 Cells , Humans , Lactones/isolation & purification , Mice , Molecular Structure , Nitric Oxide , Phytochemicals/isolation & purification , Phytochemicals/pharmacology , RAW 264.7 Cells , Sesquiterpenes/isolation & purification
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