ABSTRACT
A new species of Griseothosea nigrifasciata sp. nov. is described and illustrated from Wuyishan National Park, Fujian province, China. It differs from other members of Griseothosea by the male genitalia: uncus with strongly curved lateral margin, juxta with two finger-shaped protrusion apically, and aedeagus shorter and slenderer. The new species is supported molecularly by the analysis of a 658 bp fragment of the COI gene. A key to Griseothosea is provided.
Subject(s)
Lepidoptera , Moths , Male , Animals , Moths/genetics , Parks, Recreational , Genitalia , Animal Distribution , ChinaABSTRACT
Foot-and-mouth disease virus (FMDV) 2C, is one of the most highly-conserved viral proteins among the serotypes of FMDV. However, its effect on host cells is not very clear. Using yeast two-hybrid system and immunoprecipitation approaches, we found that FMDV 2C interacted with the N-myc and STAT interactor (Nmi) protein. When expressed in cells, FMDV 2C is mainly associated with endoplasmic reticulum in the forms of speckles. In the absence of FMDV 2C, Nmi was distributed diffusely in the cytoplasm. However, upon FMDV 2C overexpression Nmi was recruited into FMDV 2C containing speckles where both proteins are co-localized. In addition, FMDV 2C induced apoptosis in BHK-21 cells, which was markedly inhibited by Nmi knockdown, suggesting that Nmi may play a critical role in FMDV 2C-induced apoptosis. These findings may help to further understand the molecular mechanism of pathogenesis of FMDV infection.
