ABSTRACT
Traditional Chinese medicine (TCM) as a complete knowledge system researches into human health conditions via a different approach compared to orthodox medicine. We are developing a unified traditional Chinese medical language system (UTCMLS) through an ontology approach that will support TCM language knowledge storage, concept-based information retrieval and information integration. UTCMLS is a huge knowledge project, which is a broad collaboration of 16 distributed groups, most of them with no prior experience of formal ontology development. Therefore, the cooperative and comprehensive ontology engineering is crucial. We use Protégé 2000 for ontology development of concepts and relationships that represent the domain and that will permit storage of TCM knowledge. This paper focuses on the methodology, design and development of ontology for UTCMLS.
Subject(s)
Medicine, Chinese Traditional , Unified Medical Language System , Humans , Information Storage and RetrievalABSTRACT
In this preliminary study a Chinese autosomal dominant microphthalmia family were investigated and the linkage analyses were performed with six previously reported loci (CHX10, MITF, RX, MCOP, NNO1, NNO2) and six microsatellite markers on chromosome 11 as well. The allelic polymorphisms of those microsatellite markers were identified by using polymerase chain reaction, polyacrylamide gel electrophoresis and silver-staining techniques. The LOD scores between microsatellite markers and the disease were obtained by using MLINK software. Our results showed that the linkage between the microphthalmia in this family with the 6 known loci could be excluded, indicating that the defect gene in this microphthalmia family was probably distinct from those of previously reported microphthalmia families.
