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1.
J Genet Psychol ; 184(4): 287-301, 2023.
Article in English | MEDLINE | ID: mdl-36705142

ABSTRACT

The associations between the various dimensions of parenting and adolescent bullying have been widely studied, but it is unclear whether these associations vary by race/ethnicity and grade. The current study utilized the Health Behavior in School-Aged Children data in the United States for the investigation. The findings show that supportive parenting and permissive parenting were negatively associated with bullying victimization. However, controlling parenting and neglectful parenting were positively associated with bullying victimization. The results further revealed that the dimensions of parenting were similarly associated with bullying victimization across racial/ethnic groups. Parenting was also similarly associated with bullying victimization for both middle and high school students, except for supportive parenting, where middle school students with more parental support reported less bullying victimization. The implications of the findings are discussed.


Subject(s)
Bullying , Crime Victims , Adolescent , Humans , Child , United States , Parenting , Students , Schools
2.
Child Abuse Negl ; 133: 105858, 2022 11.
Article in English | MEDLINE | ID: mdl-36058065

ABSTRACT

BACKGROUND: Child maltreatment reporting is critical for case investigation and service disposition. However, reporting discrepancies across informants is a challenge for child welfare services. METHODS: Using data from the Fragile Families and Child Wellbeing Study (n = 3150), the current study examined child-caregiver discrepancies in reporting the frequencies of psychological and physical maltreatment. Multivariate models were used to examine how caregivers' reports, children's reports, and discrepancies between the two were associated with child anxiety, depression, aggression, and delinquency. RESULTS: A quarter of the children reported psychological maltreatment at a higher (25.7 %) or lower (23.8 %) frequency than their caregivers' report, respectively; 8.4 % and 8.7 % of the children did so in physical maltreatment reports, respectively. Multivariate models showed that children's maltreatment reports were more closely associated with children's anxiety, depression, and delinquency than caregivers' reports, while caregivers' reports were more closely associated with children's aggression. After accounting for caregivers' reporting and other covariates, children who reported more frequent psychological maltreatment than their caregivers' report had a higher level of anxiety, depression, and delinquency (b = 0.17 to 0.25, p < 0.001), and the opposite was true (b = -0.36 to -0.13, p < 0.001). Similarly, children who reported more frequent physical maltreatment than their caregivers' report had a higher level of all negative outcomes (b = 0.04 to 0.44; p = 0.04 to <0.00), and the opposite was true for aggression (b = -0.08, p = 0.004). CONCLUSIONS: The findings suggest that in addition to other reporting barriers, children and caregivers may perceive maltreatment differently, and such discrepancies are related to children's wellbeing.


Subject(s)
Caregivers , Child Abuse , Caregivers/psychology , Child , Child Health , Family , Humans , Mandatory Reporting
3.
Article in English | MEDLINE | ID: mdl-35328947

ABSTRACT

The COVID-19 pandemic has resulted in substantial service disruption and transition from in-person services to telehealth for children with developmental disabilities. However, there is limited knowledge about the specific dimensions and consequences of the disruption and transition. This study aims to examine the extent of service disruption and transition, the experiences of client children and their caregivers with telehealth vis-à-vis in-person services, and the impacts of the disruption and transition on child wellbeing. The cross-sectional study collected data from parents of children with developmental disabilities using an online survey. McNemar's tests were used to compare service changes before and after the pandemic outbreak, and multivariate analyses were used to examine how service changes were associated with child wellbeing. Results show that more than two-thirds of the children experienced reduction in service amount, and one-third lost services for more than two months in about five months into the pandemic. While telehealth had comparable features relative to in-person services, it had lower ratings with respect to diagnostic accuracy, treatment effectiveness, and rapport building. Service disruption/transition and social isolation were associated with behavioral and emotional deterioration in children. However, child and family stress may have confounded these adverse effects. We concluded that the magnitude of service disruption and transition was large in the first half year after the pandemic outbreak, and the amount and duration of service loss varied substantially across clients. Diagnostic accuracy, treatment efficacy, and rapport building were areas in which parents had major concerns toward telehealth relative to in-person services. However, such drawbacks may partially be due to the limited logistics in telehealth implementation during the pandemic. Service disruption and transition seemed to contribute to family stress, which played a direct role in eroding child wellbeing. Implications of these findings for future research and practices are discussed.


Subject(s)
COVID-19 , Telemedicine , COVID-19/epidemiology , Child , Child Health , Cross-Sectional Studies , Developmental Disabilities/epidemiology , Developmental Disabilities/therapy , Humans , Pandemics , Telemedicine/methods
4.
J Interpers Violence ; 37(7-8): NP5442-NP5470, 2022 04.
Article in English | MEDLINE | ID: mdl-32954892

ABSTRACT

Peer victimization patterns from elementary school transitioning into late middle school have not been assessed in detail. Even less work has considered how these patterns differ across family context and then are linked to delinquency in adolescence. This study used longitudinal data (n = 2,892) from the Fragile Families and Child Wellbeing Study to examine peer victimization classification and change over six years while distinguishing across sex and family contexts. Latent transition analysis (LTA) shows that youth can be classified into minor victimization, mainly verbal victimization, and all-type victimization subgroups over time with some sex differences, regardless of whether they were in two-parent families. The majority of the youth were in either the mainly verbal victimization (53% for boys; 42% for girls) or all-type victimization (12% for boys; 21% for girls) statuses when they were about 9 years old, but substantial transition positioned most boys (84%) and girls (82%) in the minor victimization status instead when they were about 15 years old. Youth who were Hispanic, in two-parent families, and more open to parents had a reduced risk of peer victimization, but youth who were in a poor family had an increased risk of peer victimization. Peer victimization statuses were significantly associated with youth delinquency, and there were sex and time differences in the association. In year 9, 45% to 94% of boys and 24% to 75% of girls were involved in delinquency based on their victimization statuses, but the difference was 48% to 67% for boys and 39% to 59% for girls in year 15. The findings suggest developing and implementing peer victimization prevention starting from early elementary school, concurrently addressing peer victimization and delinquency, and paying close attention to sex and family context differences.


Subject(s)
Bullying , Crime Victims , Adolescent , Child , Female , Humans , Male , Parents , Peer Group , Schools
5.
Int J Offender Ther Comp Criminol ; 66(5): 560-586, 2022 Apr.
Article in English | MEDLINE | ID: mdl-33567954

ABSTRACT

The immigrant-crime relationship is often misunderstood and highly complex. To date, criminological research has largely ignored theory testing of this relationship. This paper examines the extant literature on intergenerational offending amongst immigrant youth and subsequently tests whether the segmented assimilation theory- a theory borrowed from the interdisciplinary social sciences- adequately explains immigrant offending. The study uses data (N = 1,267) from the Pathways to Desistance Study (PTD) to examine intergenerational differences in changes to offending between immigrant youth and the native-born. The analyses largely reveal that the theory, based on its original assumptions, fails to adequately explain youth offending, and that the models provide more support for the straight-line theory of assimilation in regards to delinquency. Limitations and recommendations are discussed and proffered, respectively.


Subject(s)
Emigrants and Immigrants , Adolescent , Crime , Humans , United States
6.
Article in English | MEDLINE | ID: mdl-34948605

ABSTRACT

A growing body of research documents that bullying victimization is associated with delinquent behavior. There is an increasing need to better illuminate the factors that might moderate this relationship. This study examined whether the motivation to move out of low-resourced neighborhoods and sexual orientation/gender identity moderated the relationship between bullying victimization and delinquent behavior among a sample of 450 heterosexual and 91 non-heterosexual/cisgender African American youths. Measures considered were bullying victimization, delinquent behavior, sexual orientation/gender identity, motivation to move out, and family demographics. Sexual orientation/gender identity was not associated with youth delinquent behavior after controlling for covariates. Being motivated to move out moderated the association between bullying victimization and delinquent behavior. Sexual orientation/gender identity and being motivated to move out of low-resourced communities jointly contributed to the moderating effect between bullying victimization and delinquent behavior. For non-heterosexual/cisgender youth, bullying victimization is correlated with increased delinquent behavior for those with low motivation to move out of their communities compared with those with an average or higher level of motivation to stay. However, such a moderating effect was not shown for heterosexual youth.


Subject(s)
Bullying , Crime Victims , Sexual and Gender Minorities , Adolescent , Black or African American , Chicago , Female , Gender Identity , Heterosexuality , Humans , Male , Motivation , Sexual Behavior
7.
Article in English | MEDLINE | ID: mdl-34831952

ABSTRACT

The study investigated how pediatric speech-language pathologists (SLPs) applied telepractice to compensate for the loss of in-person services and the dynamics of telepractice use during the COVID-19 pandemic in a rural state. We conducted interviews with 10 SLPs and then a statewide survey in which 51 SLPs participated. The qualitative interviews revealed themes including changes in service environment due to the pandemic (e.g., transition to telepractice, losing clients), challenges in the transition to telepractice (e.g., limited training, difficulty engaging clients), worsening wellbeing of clinicians and clients, and SLPs' perspectives and suggestions towards telepractice in the future. Survey results showed service disruptions and transition dynamics during the pandemic. SLPs' weekly caseloads reduced from an average of 42.3 clients prior to the pandemic to 25.9 and 23.4 from March to May and from June to September 2020, respectively, and then recovered to 37.2 clients from October to December 2020. In contrast, the number of telepractice caseloads sharply increased from 0.2 clients per week prior to the pandemic to 14.8 from March to May 2020. The weekly telepractice caseloads then declined to 5.5 clients from June to September and 7.9 clients from October to December 2020. In the months right after the pandemic outbreak (i.e., March to May), client children struggled with treatment gains and behavioral wellbeing. However, their outcomes gradually improved by October to December and approached pre-pandemic levels. About one-third of the SLPs reported that they would be more likely or much more likely to use telepractice in the future regardless of the pandemic. However, only about a quarter perceived telepractice as comparable to in-person services. We concluded that the transition from in-person services to telepractice substantially mitigated service disruptions right after the pandemic outbreak and that telepractice's substitute role evolved over time.


Subject(s)
COVID-19 , Speech-Language Pathology , Telemedicine , Child , Humans , Pandemics , Pathologists , SARS-CoV-2 , Speech
8.
Article in English | MEDLINE | ID: mdl-34639381

ABSTRACT

Research has rarely examined how the COVID-19 pandemic may affect teens' social media engagement and psychological wellbeing, and even less research has compared the difference between teens with and without mental health concerns. We collected and analyzed weekly data from January to December 2020 from teens in four Reddit communities (subreddits), including teens in r/Teenagers and teens who participated in three mental health subreddits (r/Depression, r/Anxiety, and r/SuicideWatch). The results showed that teens' weekly subreddit participation, posting/commenting frequency, and emotion expression were related to significant pandemic events. Teen Redditors on r/Teenagers had a higher posting/commenting frequency but lower negative emotion than teen Redditors on the three mental health subreddits. When comparing posts/comments on r/Teenagers, teens who ever visited one of the three mental health subreddits posted/commented twice as frequently as teens who did not, but their emotion expression was similar. The results from the Interrupted Time Series Analysis (ITSA) indicated that both teens with and without mental health concerns reversed the trend in posting frequency and negative emotion from declining to increasing right after the pandemic outbreak, and teens with mental health concerns had a more rapidly increasing trend in posting/commenting. The findings suggest that teens' social media engagement and emotion expression reflect the pandemic evolution. Teens with mental health concerns are more likely to reveal their emotions on specialized mental health subreddits rather than on the general r/Teenagers subreddit. In addition, the findings indicated that teens with mental health concerns had a strong social interaction desire that various barriers in the real world may inhibit. The findings call for more attention to understand the pandemic's influence on teens by monitoring and analyzing social media data and offering adequate support to teens regarding their mental health wellbeing.


Subject(s)
COVID-19 , Social Media , Adolescent , Emotions , Humans , Pandemics , SARS-CoV-2
9.
Child Abuse Negl ; 122: 105296, 2021 12.
Article in English | MEDLINE | ID: mdl-34478999

ABSTRACT

BACKGROUND: There has been a burgeoning development of trauma-informed care (TIC) interventions for children involved with the child welfare system. A quantitative synthesis of these interventions' effects on child wellbeing is warranted for the advancement of evidence-based practices. OBJECTIVES: We conducted a systematic review and meta-analysis to estimate TIC interventions' pooled effect on the wellbeing of children involved with the child welfare system, while examining factors that may moderate the effect. METHODS: The search and review yielded 15 eligible studies. We first estimated the interventions' pooled effect based on a compound child wellbeing indicator, and then on three specific child wellbeing indicators: posttraumatic stress disorder (PTSD) symptom reduction, behavioral problem reduction, and other psychological wellbeing improvement. We further conducted subgroup meta-analyses to evaluate factors that may moderate the effect. RESULTS: TIC interventions had a moderate effect as shown through the compound child wellbeing indicator (SMD = 0.47, 95% CI = [0.27, 0.67]) as well as the three specific indicators (SMD = 0.37 to 0.52, 95% CI = [0.02, 0.88]). Subgroup meta-analyses indicated that the intervention effects varied but generally remained at a moderate level across study and intervention characteristics. CONCLUSIONS: The findings suggest that TIC interventions for children involved with the child welfare system are promising, but the effect may vary by intervention strategies and other factors. Implications for practices and research are discussed.


Subject(s)
Stress Disorders, Post-Traumatic , Child , Child Health , Child Welfare , Humans , Stress Disorders, Post-Traumatic/psychology , Stress Disorders, Post-Traumatic/therapy
10.
Article in English | MEDLINE | ID: mdl-34360163

ABSTRACT

Although the relationship between exposure to intimate partner violence and youths' psychological and other wellbeing has been widely studied, there is limited research about how youths' exposure to violence between mother and her intimate partner may be related to youth psychological wellbeing. The study used a sample of urban adolescents in Chicago Southbound to examine whether youths' exposure to verbal conflict between mother and her intimate partner is related to their suicidality and whether youth depression and aggression may be in between such a linkage. Our findings indicated that one-third of the youth had suicidal thoughts or suicidal/self-hurting attempts. Youths' exposure to verbal conflict between mother and her intimate partner was associated with their depressive and aggressive symptoms, and depressive symptoms subsequently were linked to suicidality. The findings also showed that youth depressive symptoms and aggressive symptoms were positively correlated, which may influence their associations with suicidality. We concluded that youth exposure to parental intimate partner violence, even comparatively mild forms such as a verbal conflict between mother and her intimate partner, may increase their risk of suicidality by worsening psychological wellbeing. The findings highlight the importance of tackling youth suicidality risks while accounting for their exposure to intimate partner violence including verbal conflicts between parents.


Subject(s)
Exposure to Violence , Intimate Partner Violence , Suicide , Adolescent , Chicago/epidemiology , Female , Humans , Mothers , Violence
11.
Am J Orthopsychiatry ; 91(3): 432-442, 2021.
Article in English | MEDLINE | ID: mdl-34138632

ABSTRACT

The current study applied the General Strain Theory (GST), Social Disorganization Theory (SDT), and Social Control Theory (SCT) to examine the association between exposure to verbal conflict between a mother and her intimate partner, and aggressive behavior of urban adolescents. The sample included 518 urban adolescents (96% Black), aged 14 to 17 years. Descriptive statistics, structural equation modeling (SEM), and moderation analyses were conducted. Consistent with GST, exposure to verbal conflict between the mother and her intimate partner was indirectly associated with aggression, as mediated by emotional distress. Also, consistent with SDT, neighborhood violence was positively associated with aggression. Neighborhood violence was associated with exposure to verbal conflict between their mother and her intimate partner, which was related to aggressive behavior in urban adolescents. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Subject(s)
Aggression , Intimate Partner Violence , Adolescent , Female , Humans , Interpersonal Relations , Mothers , Residence Characteristics , Violence
12.
J Affect Disord ; 290: 284-291, 2021 07 01.
Article in English | MEDLINE | ID: mdl-34015623

ABSTRACT

Although past research suggests that parental stress can heighten adolescents' risk for bullying perpetration and victimization, the mechanisms underlying such a potential link and that may involve child psychological wellbeing remain unclear. Parental stress may heighten adolescents' risk for bullying involvement by elevating adolescents' anxiety and interfering with family functioning. Therefore, the current study investigated the role of adolescent anxiety and family resilience as mediators linking parental stress with adolescent bullying involvement. Sex differences in these associations were also explored. Analyses relied on data collected from 11,244 parents who participated in the 2019 National Survey of Children's Health. Parents completed surveys assessing parental stress, adolescent anxiety, family resilience, and adolescents' involvement in bullying perpetration as well as victimization. Results from structural equation models indicated that a higher level of parental stress was related to greater bullying perpetration and victimization among both male and female adolescents. Moreover, parental stress was indirectly related to bullying victimization via elevated adolescent anxiety for both girls and boys, whereas parental stress was indirectly related to bullying perpetration via reduced family resilience for boys but not girls. The findings highlight connections between adolescents' family and peer contexts and implicate adolescent anxiety and family resilience as putative mechanisms linking parental stress and bullying involvement.


Subject(s)
Adolescent Behavior , Bullying , Crime Victims , Adolescent , Anxiety , Child , Female , Humans , Male , Parents , Peer Group
13.
Aggress Behav ; 47(3): 364-374, 2021 05.
Article in English | MEDLINE | ID: mdl-33624339

ABSTRACT

The current study examined and compared the relative influence of ecological factors on youth antisocial behaviors (i.e., aggression and rule-breaking) using longitudinal data while assessing the moderating effect of youth attention-deficit/hyperactivity disorder (ADHD) diagnosis. The study used the fifth and sixth wave of data from the Fragile Families and Child Wellbeing Study (n = 2595; mean age = 9.26 at wave five) for the analysis. Multivariate models show that youth ADHD, physically and psychologically abusive parenting, peer victimization, and community cohesion were important predictors of youth antisocial behaviors. Furthermore, youth ADHD diagnosis moderated some associations between the ecological factors and antisocial behaviors, suggesting that youth with and without ADHD may respond to some ecological contexts differently regarding the concerning behaviors. The findings imply that interventions targeting youth antisocial behaviors should involve collaboration across systems and coordination across programs to tackle a multilayered ecological context, especially when youth with ADHD are involved.


Subject(s)
Attention Deficit Disorder with Hyperactivity , Bullying , Crime Victims , Adolescent , Aggression , Antisocial Personality Disorder/epidemiology , Child , Humans , Longitudinal Studies
14.
J Interpers Violence ; 36(23-24): 11109-11139, 2021 12.
Article in English | MEDLINE | ID: mdl-31910726

ABSTRACT

The purpose of this study is to explore whether talking with parents, siblings, and friends will moderate the association between peer victimization and adverse outcomes (internalizing problems, alcohol/tobacco use, and delinquent friend affiliation). Data were derived from the Health Behavior in School-Aged Children, 2009 to 2010 cohort study in the United States (n = 12,642). Bivariate, logistic regression and ordinal least squares regression analyses were conducted. Peer victimization was found to be associated with all the adverse outcomes. Although ease of talking with parents had a lower likelihood of alcohol/tobacco use, it increased alcohol/tobacco risk when peer victimization increased. Ease of talking with friends showed a higher likelihood of alcohol/tobacco use, but the likelihood was lower when peer victimization increased. Ease of talking with parents and ease of talking with friends both lowered the likelihood of delinquent friend affiliation; however, ease of talking with parents increased the risk of delinquent friend affiliation when peer victimization increased. Moreover, ease of talking with friends decreased the risk of internalizing problems, although it increased the risk of such behaviors when peer victimization increased. Talking with siblings did not buffer the association between peer victimization and adverse outcomes. Implications for practice are also discussed.


Subject(s)
Bullying , Crime Victims , Child , Cohort Studies , Friends , Humans , Parents , Peer Group , Siblings , United States
15.
J Interpers Violence ; 36(21-22): NP11531-NP11554, 2021 11.
Article in English | MEDLINE | ID: mdl-31766969

ABSTRACT

This study aimed to examine whether bullying reporting concerns mediate the relationship between school climate and student bullying victimization as well as aggressive behavior. Data were from a sample of 301 students in Grades 6 to 8 in two minority-predominant schools in a large U.S. metropolitan area. Findings from bootstrapped structural equation modeling (SEM) analyses indicated that for male students, a higher level of perceived anti-bullying school climate was negatively associated with bullying reporting concerns, while the reporting concerns subsequently were positively associated with bullying victimization and aggressive behavior. For female students, perceived school climate was not associated with bullying reporting concerns, but the latter were also positively associated with bullying victimization and aggressive behavior. Therefore, bullying reporting concerns mediated the association between perceived school climate and bullying victimization as well as aggressive behavior for male but not female students. The findings suggest the importance of strengthening anti-bullying school climate to help students overcome bullying reporting concerns to achieve effective outcomes. The gender difference of associations between school climate and bullying reporting concerns may reflect the variation of bullying types experienced by male and female students, which calls for attention to the development of anti-bullying strategies that take into account gender differences and address various types of bullying.


Subject(s)
Bullying , Crime Victims , Aggression , Female , Humans , Male , Schools , Students
16.
Addict Behav ; 113: 106679, 2021 02.
Article in English | MEDLINE | ID: mdl-33032193

ABSTRACT

BACKGROUND: Understanding adolescent drug use mechanisms is critical for drug use prevention. Although some theories such as the gateway theory suggest that drug users gradually transition into using more addictive drugs, there is no consensus about such a hypothesis. One important factor that hinders the advancement of knowledge in this area is the scarcity of longitudinal studies examining the type of drugs adolescents initially use and the different pathways adolescents take to transition into using other drugs as they grow older. METHODS: Using the pooled sample of adolescent dug users (14-17 years old; n = 10,644) from the National Survey on Drug Use and Health (2015-2018), we constructed longitudinal data on adolescents' illicit drug use history other than the use of tobacco and alcohol based on the age of drug initiation. This allowed us to investigate what drugs were initially used by adolescents, how the use of these drugs may have progressed into a new drug, and whether there were racial/ethnic differences in the initiation and progression. The retrospective longitudinal data analyses applied life table method and Cox regression models. RESULTS: Two thirds of the adolescent drug users initiated their drug use trajectories with marijuana, one quarter with inhalants, and the remaining with hallucinogens, prescription drugs, and hard drugs. Adolescent drug users who initiated with different drugs showed unique trajectories to the use of a new drug. By year 8, the probability of using a new drug was about 40% and 70% to 80% for adolescents who initiated with inhalants and other drugs, respectively. The probability of using a new drug for adolescents who initiated with marijuana and inhalants accumulated stably over time, and its difference with that of other drug users diminished over time. The multivariate Cox regression models suggest the observed discrepancies generally held after controlling for covariates. There were also racial/ethnic differences in adolescent drug use initiation and progression, with Black/African American adolescents being the least likely to switch to the use of a new drug. CONCLUSION: Adolescents' initial use of marijuana and inhalants may lead to substantial risks of using other drugs over time. It is therefore important to screen adolescent drug use comprehensively and provide early interventions to prevent an escalation to more detrimental drugs. The findings provide new evidence to support aspects of both the gateway and generalized risk drug use theories.


Subject(s)
Cannabis , Pharmaceutical Preparations , Substance-Related Disorders , Adolescent , Ethnicity , Humans , Retrospective Studies , Substance-Related Disorders/epidemiology
17.
Child Abuse Negl ; 106: 104524, 2020 08.
Article in English | MEDLINE | ID: mdl-32450459

ABSTRACT

BACKGROUND: Kinship foster caregivers often face serious challenges but lack adequate parenting capacities and resources. The importance of parenting interventions for kinship foster caregivers has been recognized, and researchers have assessed the effect of various parenting interventions on the caregivers and children. However, no systematic review has been conducted to summarize findings related to parenting interventions targeting kinship care. OBJECTIVES: This study systematically summarizes the effect of parenting interventions on kinship foster caregivers and their cared for children, and examines the intervention strategies and research methods used in order to provide a context in which to better understand effects of interventions. METHODS: From six academic databases, 28 studies were identified for review. A data template was used to extract the following information from each study: intervention targets, research design, settings, intervention description, outcome measures, and main results for each study. RESULTS: Various parenting interventions targeting kinship foster care families have been developed to improve parenting capacities and reduce parental stress. Most of the interventions had a positive impact on the outcomes of both caregivers and children, although the assessed outcomes often differed across studies. Parenting interventions improve caregivers' parenting competency, reduce parental stress, and advance child wellbeing. However, some interventions appear less promising in achieving targeted goals. DISCUSSION: The findings suggest that promoting evidence-based parenting interventions with a special focus on kinship care is important for child welfare. Future directions for research are also discussed in this study.


Subject(s)
Caregivers/psychology , Foster Home Care/standards , Parenting/psychology , Female , Humans , Male , Outcome Assessment, Health Care , Treatment Outcome
18.
Biomed Pharmacother ; 119: 109429, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31505422

ABSTRACT

Asthma is a common obstructive airway disease characterized by inflammation and remodeling with a progressive decline in lung function. Fangxiao Formula (FXF) is an herbal medicine that has achieved significant clinical benefits toward asthma patients, but the relevant mechanism has not yet been clarified. The aim of this study was to determine the inhibitory effects of FXF on airway inflammation and remodeling, and investigate the activities of TGF­ß/Smads signaling pathway in the rat asthma model. Rats were sensitized by ovalbumin (OVA) for six weeks to establish the asthma experimental model. OVA-challenged animals were randomly divided into 5 groups and received different concentrations of FXF or dexamethasone. The animals in blank control group received saline only. Lung tissues were collected and analyzed for determining the inflammatory cells infiltration, HE and PAS staining, airway wall thickness and collagen deposition. The productions of inflammatory cytokine productions were analyzed by ELISA in the bronchoalveolar lavage (BAL) fluid. Immunohistochemical analysis was performed to measure the expression of α-SMA and PCNA in lung tissue after the treatment of FXF. The levels of TGF-ß were assessed by both immunohistology and western blotting, and the expression of p-Smad2/3 proteins were determined by western blotting analysis. Our results indicated that FXF attenuated the infiltration of inflammatory cells, decreased the production of Th2 cytokines and simultaneously increased the levels of Th1 cytokine in the asthma rat model. In addition, FXF reduced allergen-induced increased airway wall thickness, goblet cell hyperplasia and collagen deposition. Furthermore, the expression levels of TGF-ß and p-Smad3 were obviously reduced after the treatment of FXF. These results indicate that FXF alleviates airway inflammation and remodeling by restoring the balance of Th1/Th2 cytokines and the TGF-ß/Smad-3 pathway, therefor providing potential therapeutic approach for asthmatic patients.


Subject(s)
Airway Remodeling/drug effects , Asthma/physiopathology , Drugs, Chinese Herbal/therapeutic use , Inflammation/drug therapy , Inflammation/physiopathology , Lung/pathology , Smad3 Protein/metabolism , Transforming Growth Factor beta/metabolism , Animals , Bronchoalveolar Lavage Fluid , Collagen/metabolism , Cytokines/metabolism , Disease Models, Animal , Drugs, Chinese Herbal/pharmacology , Hyperplasia , Lung/drug effects , Lung/physiopathology , Male , Proliferating Cell Nuclear Antigen/metabolism , Rats, Sprague-Dawley , Signal Transduction/drug effects , Th1 Cells/drug effects , Th1 Cells/immunology , Th2 Cells/drug effects , Th2 Cells/immunology
19.
Child Abuse Negl ; 88: 1-14, 2019 02.
Article in English | MEDLINE | ID: mdl-30412783

ABSTRACT

BACKGROUND: Substance abuse has been prevalent among caregivers involved in child welfare and is a major barrier to their achieving favorable outcomes. Family Treatment Drug Courts (FTDCs) have been viewed as one of the most promising interventions but research has reported mixed effects on child welfare outcomes. No meta-analysis was conducted to synthesize the findings to reach a more generalizable conclusion. OBJECTIVE: The meta-analysis synthesized findings from existing evaluations to examine whether and to what extent FTDC participants achieved better reunification and safety outcomes than non-participants. PARTICIPANTS AND SETTING: Among 17 identified studies dated from 2004 to 2018, the pooled sample subjects in the intervention and comparison groups were 3402 and 3683 for the 16 studies on reunification outcomes, and 842 and 632 for the eight studies on child safety outcomes. METHODS: We first estimated the FTDCs' pooled effects on child reunification and safety outcomes. Furthermore, we conducted a series of subgroup meta-analysis to compare FTDCs' effects across study and program characteristics. RESULTS: Subjects participating in FTDCs were substantially more likely to achieve reunification (OR = 1.75, 95% CI = 1.38, 2.22) without increasing the risk of subsequent foster care reentry or maltreatment re-report. Subgroup meta-analysis suggests factors such as research design, FTDC model, observation length, publication type and period may contribute to FTDCs' disparities on reunification outcomes. CONCLUSIONS: The synthesized findings strengthen evidence for the implementation and expansion of FTDCs for serving substance abusing caregivers in the child welfare system.


Subject(s)
Child Abuse/psychology , Child Welfare , Family Health , Substance-Related Disorders/rehabilitation , Child , Child Abuse/legislation & jurisprudence , Delivery of Health Care , Foster Home Care , Humans , Jurisprudence
20.
Analyst ; 143(20): 4901-4906, 2018 Oct 08.
Article in English | MEDLINE | ID: mdl-30215082

ABSTRACT

Recently, considerable attention has been paid to European eggs that were found to contain the poisonous insecticide fipronil. Excessive consumption of fipronil can harm the human body, in particular, the liver, thyroid, nervous system and kidneys. As a consequence, there is an urgent need to develop a method to detect fipronil. In this work, a lanthanide coordination polymer [Eu(SIP)(H2O)4]n (1) (NaH2SIP = 5-sulfoisophthalic acid monosodium salt) was synthesized and characterized by single-crystal X-ray crystallography, elemental analysis, infrared spectrum and powder X-ray diffractions. The X-ray studies show that 1 is a two-dimensional layered structure, which is constructed of fused {[Eu(H2O)4]3(SIP)3} pseudo-hexagonal grids. The luminescence properties of 1 exhibit effective recognition for fipronil in methanol solution. Furthermore, a wide linear range (10-6-10-4 M), a low detection limit of 0.8 µM, high selectivity and excellent recyclability, reveal that 1 can potentially act as a luminescence-based sensor for quantitative and highly sensitive detection of fipronil. To the best of our knowledge, it is the first time that a metal-organic coordination polymer, as a fluorescent-based probe, has been used for the detection of fipronil. Moreover, fluorescent-based test papers of 1 have also been prepared, which can be regarded as a simple and practical method for detecting fipronil.

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