Evaluation of N and S Codoped Carbon Dots as an Environment Friendly and High-Efficiency Inhibitor for X65 Steel in an Acidic Medium.

The high content of nitrogen and sulfur-doped carbon dots (N, S-CDs) was designed to prevent the corrosion of X65 steel in an acidic medium. The corrosion-inhibiting abilities of related nanomaterials for X65 steel were acquired by electrochemical experiments, and the corroded products were investigated by FT-IR, XPS, and Raman analysis. The conclusions confirm that the N, S-CDs are a high-efficiency inhibitor. When the concentration is 200 mg/L, the inhibitive efficiency of X65 steel can reach up to 99.1% and it interacts with X65 steel through chemical and physical adsorption. Additionally, results from the spectroscopic studies show that the S-group is the main contributor to the chemical adsorption process.

Design and Optimization of Thermal Field for PVT Method 8-Inch SiC Crystal Growth.

As a wide bandgap semiconductor material, silicon carbide has promising prospects for application. However, its commercial production size is currently 6 inches, and the difficulty in preparing larger single crystals increases exponentially with size increasing. Large-size single crystal growth is faced with the enormous problem of radial growth conditions deteriorating. Based on simulation tools, the physical field of 8-inch crystal growth is modeled and studied. By introducing the design of the seed cavity, the radial temperature difference in the seed crystal surface is reduced by 88% from 93 K of a basic scheme to 11 K, and the thermal field conditions with uniform radial temperature and moderate temperature gradient are obtained. Meanwhile, the effects of different processing conditions and relative positions of key structures on the surface temperature and axial temperature gradients of the seed crystals are analyzed in terms of new thermal field design, including induction power, frequency, diameter and height of coils, the distance between raw materials and the seed crystal. Meanwhiles, better process conditions and relative positions under experimental conditions are obtained. Based on the optimized conditions, the thermal field verification under seedless conditions is carried out, discovering that the single crystal deposition rate is 90% of that of polycrystalline deposition under the experimental conditions. Meanwhile, an 8-inch polycrystalline with 9.6 mm uniform deposition was successfully obtained after 120 h crystal growth, whose convexity is reduced from 13 mm to 6.4 mm compared with the original scheme. The results indicate that the optimized conditions can be used for single-crystal growth.

Flexible Actuators Based on Conductive Polymer Ionogels and Their Electromechanical Modeling.

High-performance flexible actuators, integral components of soft robotics, hold promise for advancing applications in safe human-robot interactions, healthcare, and various other fields. Notable among these actuators are flexible electrochemical systems, recognized for their merits in low-voltage manipulation, rapid response speed, and cost-effectiveness. However, the optimization of output strain, response speed, and stability presents a significant challenge in this domain. Despite the application of diverse electrochemically active materials to enhance actuation performance, a critical need persists for corresponding electrical-mechanical models to comprehensively grasp actuation mechanisms. In this study, we introduce a novel electrochemical actuator that utilizes conductive polymer ionogel as active electrodes. This ionogel exhibits exceptional properties, including high conductivity, flexibility, and electrochemical activity. Our electrochemical actuators exhibit noteworthy bending strain capabilities and rapid response rates, achieving frequencies up to 10 Hz at a modest voltage of 1 V. An analytical model integrating ion migration and dynamic processes has been established to elucidate actuator behavior. Simulation results highlight that electrodes characterized by low resistance and high capacitance are optimal for simultaneous enhancement of bending strain and blocking force. However, the augmentation of Young's modulus, while increasing blocking force, compromises bending strain. Furthermore, a larger aspect ratio proves beneficial for unidirectional stress output, leading to increased bending strain, while actuator blocking force diminishes with greater length. These findings underscore the intricate interplay between material properties and dimensions in optimizing the performance of flexible electrochemical actuators. This work provides important practical and theoretical guidance for the manufacture of high-performance flexible actuators and the search for new smart materials.

Study on Purification Technology of Silicon Carbide Crystal Growth Powder.

Silicon carbide (SiC) is a wide-bandgap (WBG) semiconductor material, and its preparation process has strict requirements on the purity of raw materials. A self-developed medium-frequency induction heating furnace was used to carry out powder heat treatment and purification experiments on SiC powder to improve the purity of the powder. Samples with 3.5N purity were analyzed using XRD and GDMS characterization methods. It was found that under conditions of high-temperature (2200 °C) and long-time (50 h) processing, the impurity removal effect was quite good, but the powder loss was as high as 53.42%. The powder loss during the low-temperature (less than 2050 °C) and short-time process was less than 1.5%, but the purification effect was not substantial. After a prolonged processing time, the purification effect of low-temperature heat treatment conditions was improved, but the powder loss was also increased to 30%. In contrast, segmented purification processing at a low temperature in the early stage and a high temperature in the later stage achieved a good purification effect. On the premise of maintaining the utilization rate of raw materials, a 5N-purity SiC source was successfully prepared. The test results show that the contents of free Si, free C and free oxygen impurities were reduced to less than 0.01%, and the contents of Al, B, Fe, Mg, Na, Ti and other impurities were less than 1.15 ppm, which is close to the ppb level.

Optimization of thermal field of 150 mm SiC crystal growth by PVT method.

The excellent physical properties of SiC as an electronic material determine its important application prospects, especially in the new-energy industry, but the preparation of large-sized materials with high quality is not easy. Therefore, the physical fields in the growth process were modeled and studied with the help of the numerical simulation software Virtual Reactor, and its accuracy was verified by the agreement between morphology of the experimental crystal and the simulation. Additionally, the effects of thermal insulation adjustment of crystal growth thermal fields, application of seed crystals with different diameters, and shelter structure on the crystal growth process were also studied. By optimizing the crystal growth conditions, a nearly flat and slightly convex crystal growth interface was obtained successfully in our lab. Crystal quality was significantly improved, and a 6-inch SiC crystal with single polytype, high quality and low defects was successfully prepared.

Artificial Intelligence Technologies and Their Application for Reform and Development of Table Tennis Training in Complex Environments.

The development of information technology has been deployed in almost all sectors and is making life easier. In this development, the sports sector has seen tremendous expansion. In traditional table tennis training, the coach and the players have to meet daily to take appropriate training for the game. This process is time-consuming in a complex environment, and it will have a significant impact on the reformation and development of table tennis training. The utilization of improved technologies can overcome this challenge by performing training of the game online with an intelligent wireless system with advanced training mechanisms. Carrying the traditional and heavier intelligent wireless devices will be difficult for the players. In this research, the fine-grained evaluation (FGE) system is incorporated into the deep learning model to analyze the player's body postures during the training and event sessions and make them develop after each session through online training in any circumstance. The proposed FGE was compared with the traditional statistical model, and it was observed that the proposed FGE had obtained higher precision and recall values of 70% and 98.9% than the statistical model.

Comparison of arterial stiffness and ultrasound indices in patients with and without chronic obstructive pulmonary disease.

OBJECTIVE: The purpose of this study was to compare arterial stiffness and ultrasound indices in patients with and without chronic obstructive pulmonary disease. METHODS: In our retrospective study, 83 chronic obstructive pulmonary disease patients were assigned to the chronic obstructive pulmonary disease group and 80 healthy controls were enrolled. Pearson's correlation analysis software was used to analyze the correlation between arterial stiffness (including brachial ankle pulse wave velocity and ankle-brachial blood pressure index) and ultrasound index (including resistance index, pulsatility index, and intima-media thickness) at the carotid artery in chronic obstructive pulmonary disease patients. RESULTS: The ultrasound resistance index and pulsatility index level of chronic obstructive pulmonary disease group were lower than those of control group (t=6.326, 8.321, p<0.001). Compared with the control group, the chronic obstructive pulmonary disease group had higher intima-media thickness, total plaque area, and number of plaques (t=4.574, 7.493, 5.093, p<0.001). The arterial stiffness and ankle-brachial blood pressure index level in the chronic obstructive pulmonary disease group were higher than those in the control group (t=6.392, 5.109, p<0.001). Moreover, arterial stiffness in patients with chronic obstructive pulmonary disease was negatively correlated with the ankle-brachial blood pressure index, resistance index, and pulsatility index levels (p<0.05), while it is positively correlated with intima-media thickness, total plaque area, and number of plaques (p<0.05). CONCLUSION: Our results indicated that patients with chronic obstructive pulmonary disease have stiffer arteries compared with healthy control subjects; the ultrasound index could be used as an auxiliary indicator for clinical prediction of arterial stiffness, which is helpful to improve the accuracy of prediction and thus better guide clinical interventions in high-risk groups of chronic obstructive pulmonary disease in time.

Comparison of arterial stiffness and ultrasound indices in patients with and without chronic obstructive pulmonary disease

SUMMARY OBJECTIVE: The purpose of this study was to compare arterial stiffness and ultrasound indices in patients with and without chronic obstructive pulmonary disease. METHODS: In our retrospective study, 83 chronic obstructive pulmonary disease patients were assigned to the chronic obstructive pulmonary disease group and 80 healthy controls were enrolled. Pearson's correlation analysis software was used to analyze the correlation between arterial stiffness (including brachial ankle pulse wave velocity and ankle-brachial blood pressure index) and ultrasound index (including resistance index, pulsatility index, and intima-media thickness) at the carotid artery in chronic obstructive pulmonary disease patients. RESULTS: The ultrasound resistance index and pulsatility index level of chronic obstructive pulmonary disease group were lower than those of control group (t=6.326, 8.321, p<0.001). Compared with the control group, the chronic obstructive pulmonary disease group had higher intima-media thickness, total plaque area, and number of plaques (t=4.574, 7.493, 5.093, p<0.001). The arterial stiffness and ankle-brachial blood pressure index level in the chronic obstructive pulmonary disease group were higher than those in the control group (t=6.392, 5.109, p<0.001). Moreover, arterial stiffness in patients with chronic obstructive pulmonary disease was negatively correlated with the ankle-brachial blood pressure index, resistance index, and pulsatility index levels (p<0.05), while it is positively correlated with intima-media thickness, total plaque area, and number of plaques (p<0.05). CONCLUSION: Our results indicated that patients with chronic obstructive pulmonary disease have stiffer arteries compared with healthy control subjects; the ultrasound index could be used as an auxiliary indicator for clinical prediction of arterial stiffness, which is helpful to improve the accuracy of prediction and thus better guide clinical interventions in high-risk groups of chronic obstructive pulmonary disease in time.

Coordination agent-dominated phase control of nickel sulfide for high-performance hybrid supercapacitor.

The property of an active material is not only influenced by its morphology and size, but also by its crystal phase. The present phase regulation of nickel sulfide is mainly achieved by controlling the participation of sulfur source in reaction. Thus, new perspectives direct at phase control need to be explored and supplemented. Herein, we proposed a novel coordination agent-dominated phase modulation strategy assisted by a hydrothermal process. It is found that increasing the amount of coordination agent can drove the phase transformation from the initial composite of ß-NiS/α-NiS/Ni3S4 to ß-NiS/α-NiS, and then to pure ß-NiS. The mechanism of phase regulation has been proposed, and the general application of this method has been demonstrated. By employing coordination agent, the size of resulted products is reduced, and the morphology is optimized. As a result, all of the pure ß-NiS electrodes indicate significantly enhanced specific capacity than the pristine ß-NiS/α-NiS/Ni3S4 composite. Notably, the sample synthesized with 3 mmol of urea (S11) shows uniform morphology and smallest size, and it gives a highest specific capacity of 223.8 mAh g-1 at 1 A g-1, almost 1.5 times of the original sample. The fabricated S11//rGO device delivers a high energy density of 56.6 Wh·kg-1 at a power density of 407.5 W·kg-1, and keeps an impressive capacity retention of 84% after 20,000 cycles. This work put forwards a new prospect for controlling the phase and composition of nickel sulfide based on coordination chemistry.

Insight into the anti-corrosion performance of two food flavors as eco-friendly and ultra-high performance inhibitors for copper in sulfuric acid medium.

2,5-dihydroxy-1,4-dithiane (DDD) and 2,5-dimethy- [1.4] dithiane-2,5-diol (DTDD) two food flavors as environmentally-friendly inhibitors for Cu in 0.5 mol/L H2SO4 media were researched via theoretical calculation and experimental ways. Electrochemical measurement data showed that DDD and DTDD can exhibit high level anti-corrosion feature. The anti-corrosion efficiency of DDD and DTDD were as high as 99.6% and 98.9%, respectively. The atomic force microscope (AFM) and scanning electron microscope (SEM) tests showed that the Cu specimens were immersed in the H2SO4 with 5 mM DDD and DTDD for 30 h at the 298 K, and the Cu specimen surface was still smooth. Besides, the adsorption of DDD and DTDD at the interface of Cu/solution was comply with Langmuir adsorption. Theoretical calculation data showed that DDD exhibit more ascendant anti-corrosion feature than DTDD.

Study of Effect of Coil Movement on Growth Conditions of SiC Crystal.

SiC substrates have outstanding advantages over traditional materials in power device application, and are mainly prepared by a physical vapor transport method (PVT). Whether the PVT furnace works by resistance heating or induction heating, both face the problem of the deterioration of growth conditions during a long-term process. The relative position of the thermal field directly affects the crystal growth conditions, but the law of specific influence and the change in physical environment inside the thermal field have not been made sufficiently clear and lack systematic research. Therefore, SiC single crystal growth, with different directions and rates in the direction of movement of the heating module, was modeled using a simulation method, and the law of variation of the physical field, including heat flux, temperature, powder porosity and growth rate parameters under different schemes, was analyzed. The study indicates that the decay of raw materials is the primary reason why growth conditions cannot be maintained. The results verified that different coils' modes of movement have different effects on the improvement or adjustment of SiC crystals' growth conditions. Under the same temperature control conditions, the coils' movement rates of 200 µm/h, 0, -200 µm/h and -400 µm/h correspond to the average growth rates of 140, 152, 165 and 172 µm/h, respectively. The results show that downward displacement of the coils is beneficial in compensating for the deterioration of growth conditions, but it is easier to form convex surfaces and is not conducive to expanding diameter growth. This also verifies that the desired crystal growth state can be obtained by adjusting the position of the thermal field.

Relationship of idiopathic femoral head necrosis with blood lipid metabolism and coagulation function: A propensity score-based analysis.

Background: Nontraumatic osteonecrosis of the femoral head (ONFH) can be corticosteroid-induced, alcohol-induced, and idiopathic ONFH (IONFH). Although corticosteroid- and alcohol-induced ONFH has been investigated extensively regarding its relationship with blood lipids and coagulation factor levels. However, the effect of blood lipid metabolism and coagulation function on IONFH has rarely been studied. Therefore, this study aimed to analyse the relationship of IONFH with blood lipid and coagulation indicators. Methods: Total 680 patients diagnosed with IONFH in our institution during January 2011-June 2019 who met the inclusion criteria composed the case group; 613 healthy persons who underwent physical examination at our institution during the same period composed the control group. Propensity scores were used for baseline feature matching, and two matching groups each with 450 patients were established. After the matching, blood lipid and coagulation factor levels of both groups were comparatively analysed. Results: The case group showed significantly higher total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) levels, low-density/high-density lipoprotein (LDL/HDL) ratio, and apolipoprotein B (Apo-B) levels than the control group (p < 0.05). Conversely, the HDL and apolipoprotein A (Apo-AI) levels in the case group were significantly lower than those in the control group (p < 0.05). Regarding coagulation indicators, the activated partial thromboplastin time and prothrombin time were lower in the case group than in the control group; however, the differences were insignificant (p > 0.05). Furthermore, fibrinogen (FIB) levels and thrombin time (TT) in the case group were higher than those in the control group. There were significant differences between the two groups only in terms of FIB levels (p < 0.05), while TT was not significantly different (p > 0.05). Conclusions: IONFH has strong associations with blood lipid metabolism and coagulation function, which provide an avenue for exploring the mechanism of IONFH.

Template-free synthesis of ß-NiS ball-in-ball microspheres for a high-performance asymmetrical supercapacitor.

While significant advances have been made in the synthesis of core-/multi-shell materials, the synthetic process usually involves a soft/hard template and complicated procedures. In particular, it is extremely difficult to fabricate single-component core-shell structures for nickel sulfides (NSs) with a controlled phase. In this work, we demonstrate a novel facile method to synthesize a single-component ß-NiS ball-in-ball microsphere. The ball-in-ball structure is easily obtained by uniquely employing 2-mercaptopropionic acid (2-MPA) as the sulfur source and ethanol as the solvent based on the Ostwald ripening process. In particular, our work demonstrates that the chemical structure of sulfur sources and solvents plays a key role in the formation of the pure ß-NiS ball-in-ball structure. When used as an electrode active material, the ß-NiS ball-in-ball microspheres exhibit two times stronger specific capacity and three times higher rate performance than NSs produced by a hydrothermal method. The fabricated NS-2//rGO asymmetrical supercapacitor (ASC) displays an energy density of 46.4 W h kg-1 at a power density of 799.0 W kg-1 and good cycling performance. Thus, this study provides a new method for controlling the phase and morphology of NSs.

Solvothermal synthesis of functionalized carbon dots from amino acid as an eco-friendly corrosion inhibitor for copper in sulfuric acid solution.

In this work, novel N-doped carbon dots (N-CDs) were synthesized from citric acid and l-serine. The results of fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS) show that there are many unsaturated bonds and polar groups in the N-CDs. The inhibition performance of the concerned zero-dimensional nanomaterial for copper was investigated by electrochemical, combining FT-IR, XPS and Raman to investigate the corrosion products. Results indicate that the N-CDs were found to be effective inhibitor with the suppression efficiency as high as 98.5% means after immersed for 24 h, and they interacted with copper substrate by chemical & physical adsorption. Moreover, the related anticorrosion mechanism was explored and elucidated in detail. The purpose of this work is to explore eco-friendly and efficient corrosion inhibitor materials for metal protection.

LncRNA SNHG16 contributes to osteosarcoma progression by acting as a ceRNA of miR-1285-3p.

BACKGROUND: The long non-coding (lnc) RNA activated by small nucleolar RNA host gene 16 (SNHG16), which has been reported to play a vital role in a number of different types of cancer, is a novel lncRNA. However, following an osteosarcoma (OS) study, the expression pattern, biological roles, clinical values and potential molecular mechanism of SNHG16 remain unclear. In the current study, we aimed to examine its expression and possible function in osteosarcoma (OS). METHOD: Cell proliferation was measured by colony formation assay and Cell Counting Kit-8 (CCK-8) in vitro, and xenograft transplantation assay in vivo. Meanwhile, we used transwell chambers to test cell migration and invasion was evaluated. Cell cycle and apoptosis was evaluated by flow cytometry assay. Immunoblotting and qPCR analysis was carried out to detect protein and gene expression, respectively. Luciferase reporter assay was used to predict the potential downstream genes. RESULTS: The present study demonstrated that SNHG16 is highly expressed in both the tissues of patients with OS, as well as OS cell lines, and its expression level was positively correlated with clinical stage and poor overall survival. Functional assays revealed that the depletion of SNHG16 inhibits OS growth, OS cell progression and promotes apoptosis both in vivo and in vitro. In addition, the present study revealed that microRNA-1285-3p expression levels can be decreased by SNHG16 acting as a 'sponge', and that this pathway takes part in OS tumor growth in vivo, and OS cell proliferation, invasion, migration and apoptosis in vitro. CONCLUSIONS: The results from the present study demonstrate the role of lncRNA SNHG16 in OS progression, which is SNHG16 might exert oncogenic role in osteosarcoma (OS) by acting as a ceRNA of miR-1285-3p, and it may become a novel target in OS therapy.

Papaya leaves extract as a novel eco-friendly corrosion inhibitor for Cu in H2SO4 medium.

The papaya leaves were extracted via ultra-pure water. The obtained papaya leaves extract (PLE) was used as the eco-friendly inhibitor for Cu in the H2SO4 corrosion medium. The experimental results showed that PLE was a mixed-type inhibitor and exhibited excellent anti-corrosion nature over a certain temperature range. Morphological analysis test results at different temperatures strongly proved the anti-corrosion nature of PLE. The XPS test results found that an adsorption film of Cu-S bond and Cu-N bond was formed on the Cu surface. This barrier film conformed to Langmuir mono-layer adsorption. Corrosion kinetics and thermodynamic parameters were calculated and discussed.

Insight into anti-corrosion nature of Betel leaves water extracts as the novel and eco-friendly inhibitors.

In this paper, the simple and low-cost water extraction way was used to acquisition Betel leaves extracts (BLE). The water as the extraction solvent has the characteristics of low price, environmentally friendly, and good solubility for other extraction solvents. BLE was researched as an environmental-friendly inhibitor via various experimental methods and theoretical calculations. Electrochemical experiments manifest that BLE can restrain reactions of the cathode and anode of Q235 steel. The BLE concentration was 400 mg/L, the anti-corrosion efficiency was close to 94%. The experimental data show that BLE can show high-quality anti-corrosion nature for Q235 steel immersing in 1 M hydrochloric acid (HCl) environment at a certain temperature range. The morphology maps of scanning electron microscope (SEM) and atomic force microscopy (AFM) strongly proves the data of electrochemical experiments. In addition, the BLE adsorption at the Q235 steel surface belongs to the Langmuir mono-layer adsorption. Quantum chemical calculations (QCC) and molecular dynamics simulations (MDS) effectually manifest that BLE can show decent anti corrosion character.

Hyperbranched molecules having multiple functional groups as effective corrosion inhibitors for Al alloys in aqueous NaCl.

Hyperbranched molecules are a kind of promising materials due to their unique structures. In this work, two hyperbranched molecules (GON and GOH) are used as effective inhibitors for Al alloys in NaCl solution. Their inhibitive performances are evaluated by electrochemical measurements and surface characterization. The results indicate that inhibition performances of GON and GOH are closely related to the concentrations, influenced by the combination of steric hindrance and bonding effects. At relatively low concentrations (0.03-0.10 mM), GON displays a more pronounced ability to inhibit corrosion than GOH, owing to more anchoring functional groups. Oppositely, GOH has good inhibition performance at higher concentrations (0.50-1.00 mM). The interaction between the Al electrode and GOH results in the formation of a more condenser protective film than GON at high concentrations. In addition, the adsorption mechanism of two hyperbranched molecules is revealed by theoretical calculations.

Controlled synthesis of a high-performance α-NiS/Ni3S4 hybrid by a binary synergy of sulfur sources for supercapacitor.

Nickel sulfide possesses ultra-high theoretical energy storage capacity. Though it is easily obtained, it is very difficult to exert its intrinsic strong capacity. In this work, a new strategy based on a binary synergy of sulfur sources is introduced. By regulating the molar ratio of two sulfur sources, a high-performance α-NiS/Ni3S4 binary hybrid is successfully synthesized. Interestingly, it is found that changing the molar ratio of two sulfur sources in hydrothermal process can efficiently regulate the components of product but cannot visibly affect its morphology. The electrochemical results indicate that this strategy is highly effective for improving the performance of nickel sulfide. As a result, a highest specific capacity of 214.9 mAh g-1 at 2 A g-1 was reached. In addition, the fabricated S3//rGO hybrid supercapacitor displays a highest energy density of 41.9 Wh kg-1 at a power density of 799.0 kW kg-1. Moreover, the device delivers an excellent cycle stability with 103% capacity retention rate after 10,000 cycles. These findings open a new avenue for the controlled synthesis of high-performance nickel sulfides or other metal sulfides.

FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR Signaling.

BACKGROUND: Fibronectin type III domain containing 3B (FNDC3B) acts as an oncogene in various cancers, and abnormal expression of FNDC3B has been found in colorectal cancer (CRC). Our study aimed to illustrate the role of FNDC3B in CRC development. METHODS: Through RT-qPCR and western blotting assays, the mRNA and protein expressions of target genes were measured. CCK-8 and MTT methods were used to detect cell proliferation. Invasion ability was determined using Transwell assay. TargetScan platform and luciferase reporter gene assay were performed to predict and validate the bindings between FNDC3B and miR-125a-5p or miR-217. Besides, the expression correlation was measured by Pearson's Correlation analysis. RESULTS: We found that FNDC3B was significantly upregulated in CRC tissues and tumor cell lines, and high expression of FNDC3B predicted a poor survival outcome. The bindings between FNDC3B and miR-125a-5p and miR-217 were respectively at the motifs of CUCAGGG and AUGCAGU. MiR-125a-5p and miR-217 were downregulated in CRC tissues, and both were negatively correlated with FNDC3B expression. Subsequently, the downregulated miR-125a-5p and miR-217 were confirmed as contributors FNDC3B upregulation in CRC. A loss-of-function assay demonstrated that FNDC3B knockdown inhibited the proliferation of CRC cells, while FNDC3B overexpression promoted the proliferation and invasion of tumor cells. Besides, we validated that PI3K/mTOR signaling was involved in the regulation of FNDC3B on the proliferation and invasion of CRC cells. CONCLUSION: Generally, our findings demonstrated that FNDC3B facilitated cell proliferation and invasion via PI3K/mTOR signaling, and further promoted CRC progression. The novel miR-125a-5p/FNDC3B and miR-217/FNDC3B axes might be new targets for CRC prognosis and therapy.