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J Med Chem ; 66(4): 2804-2831, 2023 02 23.
Article in English | MEDLINE | ID: mdl-36780419

ABSTRACT

ABCB1 and ABCG2 are the important ATP-binding cassette (ABC) transporters associated with multidrug resistance (MDR). Herein, we designed a series of imidazo[1,2-a]pyridine derivatives as dual-target inhibitors of ABCB1 and ABCG2 through the scaffold hopping strategy. Compound Y22 displayed potential efflux function inhibitory toward both ABCB1 and ABCG2 (reversal fold: ABCB1 = 8.35 and ABCG2 = 2.71) without obvious cytotoxicity. Y22 also enhanced the potency of antiproliferative drugs in vitro. Mechanistic studies demonstrated that Y22 slightly suppressed ATPase activity but did not affect the protein expression of ABCB1 or ABCG2. Notably, Y22 exhibited negligible CYP3A4 inhibition and enhanced the antiproliferative activity of adriamycin in vivo by restoring the sensitivity of resistant cells. Thus, Y22 may be effective clinically in combination with common chemotherapy agents. In summary, Y22 is a potential dual-target inhibitor that reverses MDR by blocking the efflux function of ABCB1 and ABCG2.


Subject(s)
ATP Binding Cassette Transporter, Subfamily B, Member 2 , Antineoplastic Agents , Drug Resistance, Multiple , Drug Resistance, Neoplasm , Neoplasm Proteins , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Drug Resistance, Multiple/drug effects , Drug Resistance, Neoplasm/drug effects , Pyridines/pharmacology , ATP Binding Cassette Transporter, Subfamily B, Member 2/antagonists & inhibitors , Neoplasm Proteins/antagonists & inhibitors , Humans
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