1.
Infect Immun
; 71(9): 5355-9, 2003 Sep.
Article
in English
| MEDLINE
| ID: mdl-12933883
ABSTRACT
We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of amebic colitis. We found that blockade of TNF-alpha reduced inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytokine production but had less marked effects on inflammation and disease.